Thermal modeling of an implantable brain focal cooling device

Dinis, Hugo; Fernandes, J. M.; Silva, V.; Colmiais, Ivo; Mendes, Paulo

doi:10.1109/enbeng.2017.7889425

Cited by 4 publications

(6 citation statements)

References 8 publications

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“…The Peltier cooling system has been extensively studied for the treatment of epilepsy and has demonstrated clinical efficacy with an intraoperative application in epilepsy patients (Nomura et al, 2014). Efforts to develop clinically feasible implantable device are continuing (Dinis et al, 2017;Hata et al, 2017), and Peltier's elementbased cooling has been successfully tested in nonhuman primate (Inoue et al, 2017), as a potential clinically therapeutic strategy.…”

Section: Discussionmentioning

confidence: 99%

Targeted Temperature Management: Peltier's Element-Based Focal Brain Cooling Protects Penumbra Neurons from Progressive Damage in Experimental Cerebral Ischemia

Tauchi

Rink

Fujioka

et al. 2018

Therapeutic Hypothermia and Temperature Management

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Targeted temperature management (TTM), or therapeutic hypothermia, is one of the most potent neuroprotective approaches after ischemic and traumatic brain injuries. TTM has been applied clinically with various methods, but effective achievement and maintenance of the target temperature remain challenging. Furthermore, timing of cooling and target body and brain temperature to optimize effectiveness for neuroprotection and to minimize side effects are yet to be standardized. Focal brain cooling is a potential strategy to minimize adverse effects of systemic TTM. In this study, we report on a focal brain cooling device for animals and its effectiveness of focal cooling in several animal models of ischemic cerebral stroke. A focal brain cooling device was constructed using a Peltier's element, a thermoelectric heat pump. The device was validated for its cooling ability, and optimal settings to induce an effective intracranial temperature were determined using male Sprague-Dawley rats. Transient and permanent middle cerebral artery occlusions were experimentally induced, and focal brain cooling was applied using the device varying the timing and duration of cooling. The stroke-induced infarct and edema volumes were evaluated from Nissl-stained cryosections. The focal brain cooling device was able to decrease and subsequently maintained cerebral hypothermia in free-moving rats without altering the core temperature. The device with validated intracranial temperatures produced neuroprotective effects in the acute phase of ischemic neural death, reperfusion injury, progressing damage to the penumbra, and edema formation. In conclusion, our validated focal cooling device enabled rapid and accurate cerebral TTM in rats. Using this device, we were able to test the neuroprotective effect of focal TTM in several pathological stages of cerebral ischemia, which warrants further studies to develop clinically feasible TTM procedures for patients with cerebral stroke.

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Section: Discussionmentioning

confidence: 99%

Targeted Temperature Management: Peltier's Element-Based Focal Brain Cooling Protects Penumbra Neurons from Progressive Damage in Experimental Cerebral Ischemia

Tauchi

Rink

Fujioka

et al. 2018

Therapeutic Hypothermia and Temperature Management

View full text Add to dashboard Cite

show abstract

“…[ 11 ] While low frequency waves (i.e., high wavelength) are safe and minimally attenuated in tissues, [ 78 ] device powering significantly decreases at implantation depths above 10 mm [ 79 ] or upon misalignment of the coils. [ 80 ] Furthermore, implant miniaturization is often challenging with the efficiency of IPT decreasing drastically with reduced coil diameter, [ 43 ] and the corresponding wavelengths generated on the cm‐scale preventing focusing on mm‐scale implants. [ 81 ] Strategies that account for these limitations are being employed including 3‐coil structures which help mitigate alignment issues and increase miniturization potential of the method.…”

Section: Powering Implantable Medical Devicesmentioning

confidence: 99%

“…[ 5 ] The maximum output power for RFET has been limited by regulatory agencies to 1–10 mW cm −2 , making this technology suited for the lowest power medical devices. [ 43 ]…”

Section: Powering Implantable Medical Devicesmentioning

confidence: 99%

“…This requires a bulky external unit and inhibits implant miniaturization. [ 43 ] In a recent study, Jiang et al. developed a device for retinal stimulation [ 9 ] based on lead‐free, PUEH technology.…”

Section: Application Of Upismentioning

confidence: 99%

“…[ 42 ] IPT techniques can suffer from efficiency losses as implantation depth is increased and as devices are miniaturized. [ 43 ] RFET can be used for implant powering at depths that exceed the range of IPT, and RFET does not realize as harsh of an efficiency penalty for transducer‐receiver misalignment. However, RFET suffers from increased tissue attenuation and the total power transfer is limited by multiple regulatory agencies.…”

Section: Introductionmentioning

confidence: 99%

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Ultrasound‐Powered Implants: A Critical Review of Piezoelectric Material Selection and Applications

Turner

Senevirathne

Kilgour

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Adv Healthcare Materials

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Ultrasound‐powered implants (UPIs) represent cutting edge power sources for implantable medical devices (IMDs), as their powering strategy allows for extended functional lifetime, decreased size, increased implant depth, and improved biocompatibility. IMDs are limited by their reliance on batteries. While batteries proved a stable power supply, batteries feature relatively large sizes, limited life spans, and toxic material compositions. Accordingly, energy harvesting and wireless power transfer (WPT) strategies are attracting increasing attention by researchers as alternative reliable power sources. Piezoelectric energy scavenging has shown promise for low power applications. However, energy scavenging devices need be located near sources of movement, and the power stream may suffer from occasional interruptions. WPT overcomes such challenges by more stable, on‐demand power to IMDs. Among the various forms of WPT, ultrasound powering offers distinct advantages such as low tissue‐mediated attenuation, a higher approved safe dose (720 mW cm−2), and improved efficiency at smaller device sizes. This study presents and discusses the state‐of‐the‐art in UPIs by reviewing piezoelectric materials and harvesting devices including lead‐based inorganic, lead‐free inorganic, and organic polymers. A comparative discussion is also presented of the functional material properties, architecture, and performance metrics, together with an overview of the applications where UPIs are being deployed.

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Wireless powering and communication in RFCMOS 180 nm for implantable thermal neuromodulators

Silva

Mendes

2019

2019 IEEE 6th Portuguese Meeting on Bioengineering (ENBENG)

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Thermal modeling of an implantable brain focal cooling device

Cited by 4 publications

References 8 publications

Targeted Temperature Management: Peltier's Element-Based Focal Brain Cooling Protects Penumbra Neurons from Progressive Damage in Experimental Cerebral Ischemia

Targeted Temperature Management: Peltier's Element-Based Focal Brain Cooling Protects Penumbra Neurons from Progressive Damage in Experimental Cerebral Ischemia

Ultrasound‐Powered Implants: A Critical Review of Piezoelectric Material Selection and Applications

Wireless powering and communication in RFCMOS 180 nm for implantable thermal neuromodulators

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