Thermal-responsive poly(N-isopropyl acrylamide)/sodium alginate hydrogels: preparation, swelling behaviors, and mechanical properties

Zhang, Huijuan; Zhang, Yanan; He, Lifen; Yang, Biao; Zhu, Su‐Li; Yao, Meiyi

doi:10.1007/s00396-016-3951-2

Cited by 21 publications

(6 citation statements)

References 43 publications

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“…S4a, the tensile strengths of PNIPAM, CA and PNIPAM/CA are 1, 383 and 120 kPa, respectively. This reveals that the overall mechanical performance of PNIPAM/CA could be largely attributed to the addition of CA as the second crosslinked polymer network, which could dissipate energy under large deformation [48,61,62].…”

Section: Studies On Mechanical Propertiesmentioning

confidence: 94%

Anisotropic nanocomposite hydrogels with enhanced actuating performance through aligned polymer networks

et al. 2020

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Anisotropic composite hydrogels have wide applications in the fields of materials for actuators and sensors. Herein, we report an anisotropic composite hydrogel prepared by a mechanical-strain-induced method. Polymer networks including poly(N-isopropylacrylamide) (PNIPAM) and sodium alginate (SA), as well as carbon nanotubes (CNTs) are found to align simultaneously by stretching, and then fixed by physical crosslinking through non-covalent bonds. Composite hydrogels with doubly aligned polymer networks showed anisotropic optical and mechanical properties. The actuation performance of the anisotropic composite hydrogels as compared with the isotropic ones was found to be enhanced, which showed the capability of lifting 100 times its weight with 20% contraction strain. Besides, a bilayer hydrogel was designed to bend with a maximum of 390°to mimic the tendril behavior of plants.

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Section: Studies On Mechanical Propertiesmentioning

confidence: 94%

Anisotropic nanocomposite hydrogels with enhanced actuating performance through aligned polymer networks

et al. 2020

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“…However, the biocompatibility of the composite hydrogel was still not good enough and thus needed further improvement. On the basis of a large number of previous studies, it is found that SA had good softness, which may be used to further change the softness or rigidity of hydrogel, while Gel with good biocompatibility could be used to improve the cytocompatibility of hydrogel . Thus, in the present study, the PAM/GO/Gel/SA composite hydrogels were prepared by adding SA and Gel under the condition of PAM/GO fixation ratio through in situ free polymerization.…”

Section: Discussionmentioning

confidence: 98%

Construction of polyacrylamide/graphene oxide/gelatin/sodium alginate composite hydrogel with bioactivity for promoting Schwann cells growth

Zhao

Wang

Niu

et al. 2018

J Biomedical Materials Res

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Various hydrogels made from natural or synthetic polymers have been widely used in biologic tissues, drug delivery, and artificial implants due to their good biocompatibility, indicating a promising perspective in regenerative medicine. In the present study, a composite hydrogel named polyacrylamide/graphene oxide/gelatin/sodium alginate (PAM/GO/Gel/SA) for accelerating peripheral nerve regeneration was fabricated through in situ free radical polymerization for the first time. A series of physicochemical properties including morphology, porosity, swelling behaviors, component, mechanical properties, and in vitro degradation behavior of the prepared composite hydrogel were characterized. The effects of the composite hydrogel on Schwann cells growth were evaluated and the related molecular mechanism was further penetrated. The results showed that the prepared PAM/GO/Gel/SA composite hydrogels displayed different color appearance as the function of component variations. The surface morphology, components, swelling ratio, mechanical properties, and porosity were all changed with the concentration alteration of each ingredient, while no obvious degradation behavior was observed, indicating a controllable physicochemical property. The culture of cells exhibited that the composite hydrogels could well support the attachment and proliferation of Schwann cells. The gene expression levels of Sox10, GAP43, and myelin basic protein (MBP) in PGG SYR1 and PGG SYR0.5 were higher than those of NC. This study may provide important theoretical and experimental basis for the design and development of hydrogel scaffolds for nerve tissue engineering application. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 1951-1964, 2018.

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“…These results imply that these tough hydrogels are as tough as natural rubbers [ 83 , 88 , 89 , 90 ]. Many synthetic and natural polymers are used in the preparation of these tough hydrogels such as poly(vinylpyrrolidone) [ 91 ], poly(acrylamide) [ 92 ], poly(acrylic acid) [ 93 ], poly( N -isopropylacrylamide) [ 94 , 95 ], poly(2-acrylamido-2-methylpropanesulfonic acid) [ 82 ], poly(ethylene glycol) [ 96 ], alginate [ 83 ], agarose [ 97 ], and chitosan [ 98 ]. The first generation of double network (DN) hydrogels as reported by Gong and co-workers utilized covalent crosslinkers.…”

Section: Tough Hydrogels With Excellent Load-bearing Performancementioning

confidence: 99%

Drug Delivery Based on Stimuli-Responsive Injectable Hydrogels for Breast Cancer Therapy: A Review

Xin

Naficy

2022

Gels

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Breast cancer is the most common and biggest health threat for women. There is an urgent need to develop novel breast cancer therapies to overcome the shortcomings of conventional surgery and chemotherapy, which include poor drug efficiency, damage to normal tissues, and increased side effects. Drug delivery systems based on injectable hydrogels have recently gained remarkable attention, as they offer encouraging solutions for localized, targeted, and controlled drug release to the tumor site. Such systems have great potential for improving drug efficiency and reducing the side effects caused by long-term exposure to chemotherapy. The present review aims to provide a critical analysis of the latest developments in the application of drug delivery systems using stimuli-responsive injectable hydrogels for breast cancer treatment. The focus is on discussing how such hydrogel systems enhance treatment efficacy and incorporate multiple breast cancer therapies into one system, in response to multiple stimuli, including temperature, pH, photo-, magnetic field, and glutathione. The present work also features a brief outline of the recent progress in the use of tough hydrogels. As the breast undergoes significant physical stress and movement during sporting and daily activities, it is important for drug delivery hydrogels to have sufficient mechanical toughness to maintain structural integrity for a desired period of time.

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Thermal-responsive poly(N-isopropyl acrylamide)/sodium alginate hydrogels: preparation, swelling behaviors, and mechanical properties

Cited by 21 publications

References 43 publications

Anisotropic nanocomposite hydrogels with enhanced actuating performance through aligned polymer networks

Anisotropic nanocomposite hydrogels with enhanced actuating performance through aligned polymer networks

Construction of polyacrylamide/graphene oxide/gelatin/sodium alginate composite hydrogel with bioactivity for promoting Schwann cells growth

Drug Delivery Based on Stimuli-Responsive Injectable Hydrogels for Breast Cancer Therapy: A Review

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