Thermal Stability and Surface Wettability Studies of Polylactic Acid/Halloysite Nanotube Nanocomposite Scaffold for Tissue Engineering Studies

Nizar, Mohd; Hamzah, Mohd Syahir Anwar; Razak, Saiful Izwan Abd; Nayan, Nadirul Hasraf Mat

doi:10.1088/1757-899x/318/1/012006

Cited by 14 publications

(6 citation statements)

References 31 publications

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“…Biomaterials thermal properties, such as low impedance for neural probes and durability for scaffolds, are crucial to their suitability for neural tissues applications. [ 1,63 ] To determine the thermal properties of PHB and melanin‐PHB scaffolds, we performed a calorimetry study with a differential scanning calorimeter (Section 2.4.4 in the Experimental Section). We observed a negative peak during the heating cycle, corresponding to the melting temperature ( T m ) of the nanofibers, suggesting a deformation in the fiber structure, whereas no peak was observed during the cooling cycle, indicating that the polymer does not further undergo a state change after melting (Figure 3C–E).…”

Section: Resultsmentioning

confidence: 99%

“…The water contact angle is an important parameter to predict the adhesion of cells to the scaffold and is critical to define the its suitability for biological applications. [ 4,63,64 ] Surfaces displaying contact angles lower than 90° are considered hydrophilic. Our findings showed that the value of the contact angles for pure PHB fibers was significantly higher (100.03 ± 1.24°, ** p < 0.0001) than the one of melanin‐PHB scaffolds (61.82 ± 3.40°) (Figure 4E), suggesting that blending of melanin increased the hydrophilicity of the resulting fibers, possibly improving protein adsorption and cell adhesion on the scaffolding surface.…”

Section: Resultsmentioning

confidence: 99%

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Biodegradable and Electrically Conductive Melanin‐Poly (3‐Hydroxybutyrate) 3D Fibrous Scaffolds for Neural Tissue Engineering Applications

Agrawal

Vimal

Barzaghi

et al. 2022

Macromolecular Bioscience

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Due to the severity of peripheral nerve injuries (PNI) and spinal cord injuries (SCI), treatment options for patients are limited. In this context, biomaterials designed to promote regeneration and reinstate the lost function are being explored. Such biomaterials should be able to mimic the biological, chemical, and physical cues of the extracellular matrix for maximum effectiveness as therapeutic agents. Development of biomaterials with desirable physical, chemical, and electrical properties, however, has proven challenging. Here a novel biomaterial formulation achieved by blending the pigment melanin and the natural polymer Poly-3-hydroxybutyrate (PHB) is proposed. Physio-chemical measurements of electrospun fibers reveal a feature rich surface nano-topography, a semiconducting-nature, and brain-tissue-like poroviscoelastic properties. Resulting fibers improve cell adhesion and growth of mouse sensory and motor neurons, without any observable toxicity. Further, the presence of polar functional groups positively affect the kinetics of fibers degradation at a pH (≈7.4) comparable to that of body fluids. Thus, melanin-PHB blended scaffolds are found to be physio-chemically, electrically, and biologically compatible with neural tissues and could be used as a regenerative modality for neural tissue injuries. A biomaterial for scaffolds intended to promote regeneration of nerve tissue after injury is developed. This biomaterial, obtained by mixing the pigment melanin and the natural polymer PHB, is biodegradable, electrically conductive, and beneficial to the growth of motor and sensory neurons. Thus, it is believed that this biomaterial can be used in the context of healthcare applications.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Biodegradable and Electrically Conductive Melanin‐Poly (3‐Hydroxybutyrate) 3D Fibrous Scaffolds for Neural Tissue Engineering Applications

Agrawal

Vimal

Barzaghi

et al. 2022

Macromolecular Bioscience

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“…Hydrophilic surfaces are regarded having a contact angle < 90 • , while hydrophobic surfaces ≥ 90 • . The PLA contact angle is 110.10 • [41], classifying it as considerably more hydrophobic than AM with a contact angle of 70 • (Figure 5). The cross-sections of the AM/PLA/CNF (Figure 4e-g) appeared considerably more homogeneous compared to the AM/PLA films, exhibiting no phase separation but rather a rugged structure.…”

Section: Wettability By Water Contact Anglementioning

confidence: 99%

Biocomposite Films of Amylose Reinforced with Polylactic Acid by Solvent Casting Method Using a Pickering Emulsion Approach

Faisal,

Kirkensgaard,

Jørgensen

et al. 2024

Colloids and Interfaces

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Binary and ternary blends of amylose (AM), polylactic acid (PLA), and glycerol were prepared using a Pickering emulsion approach. Various formulations of AM/PLA with low PLA contents ranging from 3% to 12% were mixed with AM matrix and reinforced with 25% cellulose nanofibers (CNF), and PLA-grafted cellulose nanofibers (g-CNF), the latter to enhance miscibility. Polymeric films were fabricated through solvent casting and characterized using Scanning Electron Microscopy (SEM), Fourier Transform Infrared Spectroscopy (FTIR), and Wide-Angle X-ray Scattering (WAXS), and the evaluations of physical, mechanical properties, and wettability were performed using contact angle measurements. The binary blends of AM and PLA produced films suitable for packaging, pharmaceutical, or biomedical applications with excellent water barrier properties. The ternary blends of AM/CNF/PLA and AM/g-CNF/PLA nanocomposite films demonstrated enhanced tensile strength and reduced water permeability compared to AM/PLA films. Adding g-CNF resulted in better homogeneity and increased relative crystallinity from 33% to 35% compared to unmodified CNF. The application of Pickering emulsion in creating AM-based CNF/ PLA composites resulted in a notable enhancement in tensile strength by 47%. This study presents an effective approach for producing biodegradable and reinforced PLA-based nanocomposite films, which show promise as bio-nanocomposite materials for food packaging applications.

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“…Then the polymer material and the porogen mixed emulsion are added to the mold for evaporative solidification. Finally, residual porogen particles are removed 43–53 . The technology relies on molds and porogens, and different shapes of scaffolds can be constructed using different molds.…”

Section: Pla‐based Scaffold Manufacturing Technologymentioning

confidence: 99%

“…Further, some scholars choose to combine low‐temperature freeze‐drying technology to construct scaffolds 45,46 . However, the solvent casting‐particle leaching technique has some limitations, and the size and ratio of porogen particles can easily affect the pore structure inside the scaffold.…”

Section: Pla‐based Scaffold Manufacturing Technologymentioning

confidence: 99%

Recent progress in 3D printing degradable polylactic acid‐based bone repair scaffold for the application of cancellous bone defect

Lin

et al. 2022

MedComm – Biomaterials and Applications

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Large size bone defects have become a growing clinical challenge. Cancellous bone, which has the highest volume ratio, the fastest replacement rate, and interconnected porous structure, plays a major role in bone repairing. Considering the structure and composition of cancellous bone, building a bionic 3D scaffold via customized‐3D printing technology is the key to solving the problem. As the earliest degradable medical polymer material approved by Food and Drug Administration, polylactic acid has been proved to have excellent biosafety and can be copolymerized or blended with other synthetic polymers, natural polymers, and inorganic materials to improve its performance to better meet clinical applications. A series of biodegradable bone repair scaffolds based on polylactic acid composites and 3D printing technology are developed to achieve large bone defects. Here, we review the composition and structure of cancellous bone, highlighting the relationship to the requirements of bone repair scaffolds. The different types of polylactic‐acid‐based materials applied in 3D printing technology are described, emphasizing the connection between materials, preparation methods, and applications.

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Thermal Stability and Surface Wettability Studies of Polylactic Acid/Halloysite Nanotube Nanocomposite Scaffold for Tissue Engineering Studies

Cited by 14 publications

References 31 publications

Biodegradable and Electrically Conductive Melanin‐Poly (3‐Hydroxybutyrate) 3D Fibrous Scaffolds for Neural Tissue Engineering Applications

Biodegradable and Electrically Conductive Melanin‐Poly (3‐Hydroxybutyrate) 3D Fibrous Scaffolds for Neural Tissue Engineering Applications

Biocomposite Films of Amylose Reinforced with Polylactic Acid by Solvent Casting Method Using a Pickering Emulsion Approach

Recent progress in 3D printing degradable polylactic acid‐based bone repair scaffold for the application of cancellous bone defect

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