Thermal studies of Albizia inopinata crude extract in the presence of cyclodextrin and Aerosil® by TG and DSC coupled to the photovisual system

Medeiros, Ana Cláudia Dantas de; Medeiros, Isac Almeida de; Macêdo, Rui Oliveira

doi:10.1016/s0040-6031(02)00089-8

Cited by 16 publications

(4 citation statements)

References 2 publications

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“…The above-described solution found its way into commercially available devices, such as a DSC-50 photovisual system (Shimadzu) [ 18 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 ] and TG-DSC 1 (Mettler-Toledo) [ 37 , 39 , 40 , 42 ]. The literature also describes a commercially available TG/DTA device (Seiko) that allows three simultaneous measurements: TG, DTA and observation of the sample during heating [ 79 ].…”

Section: Simultaneous Dsc Measurementsmentioning

confidence: 99%

Coupled and Simultaneous Thermal Analysis Techniques in the Study of Pharmaceuticals

Wesołowski

Leyk

2023

Pharmaceutics

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Reliable interpretation of the changes occurring in the samples during their heating is ensured by using more than one measurement technique. This is related to the necessity of eliminating the uncertainty resulting from the interpretation of data obtained by two or more single techniques based on the study of several samples analyzed at different times. Accordingly, the purpose of this paper is to briefly characterize thermal analysis techniques coupled to non-thermal techniques, most often spectroscopic or chromatographic. The design of coupled thermogravimetry (TG) with Fourier transform infrared spectroscopy (FTIR), TG with mass spectrometry (MS) and TG with gas chromatography/mass spectrometry (GC/MS) systems and the principles of measurement are discussed. Using medicinal substances as examples, the key importance of coupled techniques in pharmaceutical technology is pointed out. They make it possible not only to know precisely the behavior of medicinal substances during heating and to identify volatile degradation products, but also to determine the mechanism of thermal decomposition. The data obtained make it possible to predict the behavior of medicinal substances during the manufacture of pharmaceutical preparations and determine their shelf life and storage conditions. Additionally, characterized are design solutions that support the interpretation of differential scanning calorimetry (DSC) curves based on observation of the samples during heating or based on simultaneous registration of FTIR spectra and X-ray diffractograms (XRD). This is important because DSC is an inherently non-specific technique. For this reason, individual phase transitions cannot be distinguished from each other based on DSC curves, and supporting techniques are required to interpret them correctly.

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Section: Simultaneous Dsc Measurementsmentioning

confidence: 99%

Coupled and Simultaneous Thermal Analysis Techniques in the Study of Pharmaceuticals

Wesołowski

Leyk

2023

Pharmaceutics

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“…Lewis, à qual são atribuídos efeitos vasodilatador e anti-hipertensivo. O extrato com β-ciclodextrina apresentou a melhor estabilidade e o dióxido de silício coloidal apresentou melhor aparência e menor estabilidade (De Medeiros et al, 2002). Georgetti et al (2008) avaliaram os efeitos da técnica de spray drying sobre as propriedades químicas e biológicas de extratos de soja.…”

Section: Aplicações Da Técnica E Sua Interferência Na Qualidade Dos Punclassified

Secagem por aspersão (spray drying) de extratos vegetais: bases e aplicações

Oliveira¹,

Petrovick²

2010

Rev. bras. farmacogn.

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RESUMO:A maioria dos medicamentos fitoterápicos registrados no Brasil apresenta-se sob a forma farmacêutica sólida, utilizando extratos secos como principal matéria-prima ativa. A técnica de secagem por aspersão (spray drying) tem sido amplamente aplicada na obtenção de extratos secos com melhores características tecnológicas e maior concentração de constituintes com atividade biológica. As propriedades físico-químicas dos produtos produzidos por spray drying são influenciadas por fatores relacionados ao processo, à formulação (material de entrada) e ao equipamento. Nesta revisão são apresentados e discutidos resultados de trabalhos relacionados a parâmetros de processo e formulação, e as aplicações da técnica com enfoque no desenvolvimento de extratos secos oriundos de vegetais, principalmente da flora medicinal brasileira.Unitermos: Secagem por aspersão, produtos naturais, extratos secos, processo.ABSTRACT: "Spray drying of plant extracts: basic remarks and application". In Brazil, the majority of the approved phytomedicines are formulated as solid dosage forms containing plant dried extracts as active component. Spray drying technique has been widely used to obtain dried extracts presenting better technological characteristics and greater concentration of biological active constituents. Physicochemical properties of such products depend on factors related to process, formulation (inlet material) and equipment. This review presents and discusses some studies related to parameters of process and formulation, as well as some technical applications focusing on the development of dried extract from plants, mainly from the Brazilian medicinal flora.

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“…DSC has been used as a useful tool in drug analysis to access information about drug-drug and drug-excipient interactions (van Windenn et al, 1998;Adeyeye, Price, 1991), molecular complexation (Souza et al, 2002;Medeiros et al, 2002;Bettinetti et al, 1992;Castelli et al, 1992) and materials stability and compatibility ( Medeiros et al, 2002;Coffin, McGinnity, 1992;Koenignauer et al, 1992;Torricelli et al, 1991) in pharmaceutical formulations. The modification of the physicochemical properties of dehydrated drug/lipid systems also can be easily accessed by DSC analysis (Bermúdez et al, 1999;Kinigt, 1981;Biltonen, Lichtenberg, 1993;Castelli, et al, 2001;van Winden et al, 1997;SanchesMigallon et al, 1996;Rodante et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

“…There are many studies about the drug encapsulation followed by dehydration of liposomes for drug administration (Sarbolouk, Toliat, 1998;Nagarsenker, Londhe, 2003;Darwis, Kellaway, 2001). Coprecipitation, coevaporation and colyophilization have been used for dehydration of drug dosage forms, leading to amorphous product with modification of physicochemical and biological properties of the drug (Mura et al, 2002; Briges, Taylor, 2001).DSC has been used as a useful tool in drug analysis to access information about drug-drug and drug-excipient interactions (van Windenn et al, 1998;Adeyeye, Price, 1991), molecular complexation (Souza et al, 2002;Medeiros et al, 2002; Bettinetti et al, 1992;Castelli et al, 1992) and materials stability and compatibility ( Medeiros et al, 2002;Coffin, McGinnity, 1992;Koenignauer et al, 1992;Torricelli et al, 1991) in pharmaceutical formulations. The modification of the physicochemical properties of dehydrated drug/lipid systems also can be easily accessed by DSC analysis (Bermúdez et al, 1999; Kinigt, 1981; Biltonen, Lichtenberg, 1993;Castelli, et al, 2001;van Winden et al, 1997; SanchesMigallon et al, 1996;Rodante et al, 2002).…”

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confidence: 99%

Interaction of sodium diclofenac with freeze-dried soya phosphatidylcholine and unilamellar liposomes

Lopes¹,

Scarpa²,

Pereira³

et al. 2006

Rev. Bras. Cienc. Farm.

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Phospholipids are widely used as structural amphiphilic compounds in liposome formulations. In this study, we have analyzed the interaction the sodium diclofenac (SD) with soya phosphaditylcholine (PC) and soya phosphatidylcholine from lyophilized small unilamellar liposomes (SUV). The changes in the properties of the co-lyophilized drug/PC from SUV liposomes, lyophilized PC from SUV liposomes, and lyophilized soya phosphatidylcholine, were studied by Differential Scanning Calorimetry (DSC). The DSC data showed that the previous organization of phospholipids molecules to form liposome affects intensely the thermal behavior of PC when compared to nonlipossomal PC. SD modified the thermal properties of PC from liposomes. It was verified that SD affects intensely the located group peaks in the regions of °C and in the higher temperature region of °C . The results of this work demonstrated that the presence of the drug modified the DSC behavior for both liposomal and non-liposomal PC and that these modifications can be easily monitored by DSC analysis. Diclofenac,amino] benzeneacetic acid) is a non-steroidal anti-inflammatory drug with good analgesic properties; however it may causes side effects including gastrointestinal disorders when administered by oral route and cutaneous lesion by intramuscular injection (Giovannetti et al., 1993). INTRODUCTIONPhospholipids are frequently used as structural amphiphilic compounds in colloidal drug delivery systems such as liposomes and microemulsions (Canto et al., 1999;Lima, Oliveira, 2002;Komatzu et al., 2001). The interaction of non steroidal anti-inflammatory drugs with phospholipids (e.g. phosphatidylcholine (PC)) is of importance in the pharmaceutical field due to modification of bioavailability improving the drug efficacy (Lichtenberger et al., 1996a, b) and to decrease side effects (Lichtenberger et al., 1995; Schutze, Muller-Goymann, 1998).Liposomes are colloidal supramolecular aggregates frequently used as drug carriers for a wide range of drugs including analgesics and anti-inflammatories (Canto et al., 1999;Lima, Oliveira, 2002;Lasic, 1997;Venema, Weringa, 1987; Bermúdez et al., 1999; L.B. Lopes, M.V. Scarpa, N.L. Pereira, L.C. Oliveira, A.G. Oliveira 498 2001). However, in spite of the properties highly biocompatible of the phosphatidylcholine that can protect the local tissue from the side effects of the antiinflammatory drug (Lima, Oliveira, 2002 ), PC is not sufficiently stable in aqueous medium and decomposes by hydrolysis and oxidation (New, 1997). Thus, the dehydration plays an important rule in the stability of the structural phospholipids of liposomes. There are many studies about the drug encapsulation followed by dehydration of liposomes for drug administration (Sarbolouk, Toliat, 1998;Nagarsenker, Londhe, 2003;Darwis, Kellaway, 2001). Coprecipitation, coevaporation and colyophilization have been used for dehydration of drug dosage forms, leading to amorphous product with modification of physicochemical and biological properties of the drug (Mura et ...

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Thermal studies of Albizia inopinata crude extract in the presence of cyclodextrin and Aerosil® by TG and DSC coupled to the photovisual system

Cited by 16 publications

References 2 publications

Coupled and Simultaneous Thermal Analysis Techniques in the Study of Pharmaceuticals

Coupled and Simultaneous Thermal Analysis Techniques in the Study of Pharmaceuticals

Secagem por aspersão (spray drying) de extratos vegetais: bases e aplicações

Interaction of sodium diclofenac with freeze-dried soya phosphatidylcholine and unilamellar liposomes

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