Thermally and magnetically dual‐responsive mesoporous silica nanospheres: preparation, characterization, and properties for the controlled release of sophoridine

Dong, Lijie; Peng, Hailong; Wang, Shenqi; Zhang, Zhong; Li, Jinhua; Ai, Fanrong; Zhao, Qiang; Luo, Ming; Xiong, Hua; Chen, Lingxin

doi:10.1002/app.40477

Cited by 57 publications

(31 citation statements)

References 50 publications

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“…The water-compatible M-MIPs of vanillin were synthesized via a multi-step polymerization method, as illustrated in Figure 1. Superparamagnetic Fe 3 O 4 nanoparticles were produced using the co-precipitation method 24 and then coated with a thin film of silica to enhance the dispersibility of magnetic particles and prevent oxidation. MPS was then allowed to react with the hydroxyl of Fe 3 O 4 @ SiO 2 to introduce vinyl groups, which induced the copolymerization of MIPs to occur on the surface of the microspheres upon the addition of MAA.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Preparation and Characterization of Superparamagnetic Molecularly Imprinted Polymers for Selective Adsorption and Separation of Vanillin in Food Samples

Ning

Peng

Dong

et al. 2014

J. Agric. Food Chem.

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Novel water-compatible superparamagnetic molecularly imprinted polymers (M-MIPs) were prepared by coating superparamagnetic Fe 3 O 4 nanoparticles with MIPs in a methanol−water reaction system. The M-MIPs were used for the selective adsorption and separation of vanillin from aqueous solution. The M-MIPs were characterized by X-ray powder diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA), vibrating sample magnetometry (VSM), and scanning electron microscopy (SEM). Results indicated that a core−shell structure of M-MIPs was obtained by coating a layer of silica and MIPs on the surface of the Fe 3 O 4 nanoparticles. The obtained M-MIPs possess a loose and porous structure and can be rapidly separated from the solution using a magnet. The adsorption experiments showed that the binding capacity of the M-MIPs was significantly higher than that of the superparamagnetic non-molecularly imprinted polymers (M-NIPs). Meanwhile, the adsorption of M-MIPs reached equilibrium within 100 min, and the apparent maximum adsorption quantity (Q max ) and dissociation constant (K d ) were 64.12 μmol g −1 and 58.82 μmol L −1 , respectively. The Scatchard analysis showed that homogeneous binding sites were formed on the M-MIP surface. The recoveries of 83.39−95.58% were achieved when M-MIPs were used for the pre-concentration and selective separation of vanillin in spiked food samples. These results provided the possibility for the separation and enrichment of vanillin from complicated food matrices by M-MIPs.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Preparation and Characterization of Superparamagnetic Molecularly Imprinted Polymers for Selective Adsorption and Separation of Vanillin in Food Samples

Ning

Peng

Dong

et al. 2014

J. Agric. Food Chem.

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“…[54,55] Typically when the temperature is below 32 8Ct he polymer is fully hydrated, but when the temperature increases above 32 8Ct he polymer shrinksc hanging dramatically its solvation. Somep olymers are sensitive to temperature change in ap articulars olvent, generally water,b eing soluble below (lower criticals olution temperature, LCST) or above ac ertain temperature (upper criticals olution temperature, UCST).…”

Section: Superparamagnetic Heatingmentioning

confidence: 99%

Externally Controlled Nanomachines on Mesoporous Silica Nanoparticles for Biomedical Applications

2016

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Many machines (including nanomachines) consist of a solid support with moving parts that can undergo large amplitude motion to carry out specific tasks. In this Minireview, we will describe nanomachines that are supported on mesoporous silica nanoparticles that are typically 50-100 nanometers in diameter and have an array of open, readily accessible pores with an average width of a few nanometers. For triggering a large amplitude motion of the moving parts, we will focus primarily on external stimuli such as heat or light. As for the specific task the machines are carrying out, this Minireview will focus on the controlled release of pharmaceutically active agents in biomedical applications. We will discuss examples of how nanomachines can be used for remotely controlled cargo release and how existing machines that were originally designed to respond to internal physiological stimuli could be reconfigured to respond to external stimuli instead.

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“…The inevitable interaction between the drug and the silica matrix is a surface phenomenon 5. When the unmodified silica‐based materials are used, the appearance of initial burst release of the drug is quite obvious, and in some cases, an irregular and unexpected pattern of drug release is also observed 5, 11, 34, 35. The silica‐based materials modified by the biopolymers or surfactants showed some degree of control in their initial burst release of the drugs with controllable release pattern in an extended period of time 5, 16, 26, 36–39.…”

Section: Future Perspectivesmentioning

confidence: 99%

The Silica‐based Formulations for Drug Delivery, Bone Treatment, and Bone Regeneration

Chowdhury

2016

ChemBioEng Reviews

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The utilization of the silica-based materials in biomedical applications is evolving at a rapid pace with attentions mostly devoted to the ordered mesoporous silica nanoparticles (MSNs). However, apart from the ordered-MSNs, a range of other silicabased materials have been extensively applied in the controlled release (CR) of drugs, bone treatments, and bone regeneration, but have gained less attention. This article presents an overview on the recent research advancements of the silica-based materials, i.e., silica xerogels, silica microspheres, silica hybrids, silica microcapsule particles, silica ceramics, silica bioactive glasses, and silica beads which are mainly used in CR of drugs, bone disease treatments, and bone regeneration. The in vitro and in vivo biological evaluations on these silica-based materials for antibacterial properties, osteoblast cell activities, osteogenetic performances, cell adhesion and proliferation, bio-mineralization, and material degradation are discussed. The effect of morphology or surface modifications and addition of bone morphogenetic proteins to the silica-based formulations are illustrated.

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Thermally and magnetically dual‐responsive mesoporous silica nanospheres: preparation, characterization, and properties for the controlled release of sophoridine

Cited by 57 publications

References 50 publications

Preparation and Characterization of Superparamagnetic Molecularly Imprinted Polymers for Selective Adsorption and Separation of Vanillin in Food Samples

Preparation and Characterization of Superparamagnetic Molecularly Imprinted Polymers for Selective Adsorption and Separation of Vanillin in Food Samples

Externally Controlled Nanomachines on Mesoporous Silica Nanoparticles for Biomedical Applications

The Silica‐based Formulations for Drug Delivery, Bone Treatment, and Bone Regeneration

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