Thermally reversible xyloglucan gels as vehicles for nasal drug delivery

Abstract

The aim of this study was to investigate the potential application of thermosensitive gels formed by a xyloglucan polysaccharide derived from tamarind seed for nasal drug delivery. Xyloglucan that had been partially degraded by β-galactosidase to eliminate 45% of galactose residues formed gels at concentrations of 2.5% w/w at gelation temperatures decreasing over the range 27-28°C. The in vitro release of ondansetron hydrochloride from the enzyme-degraded xyloglucan gels followed higuchi kinetics over a period of 5 h at 34°C by anomalous transport mechanism. The ex vivo permeation of ondansetron hydrochloride from the gels was sustained. Histological examination of nasal mucosa following a single administration of the gels showed no evidence of mucosal damage. Finally, the bioavailability study in rabbits revealed that the absolute bioavailability of ondansetron hydrochloride was significantly increased from 28.64% in the case of the oral drug solution to 52.79% in the case of the nasal in situ gel. The results of this study suggest the potential of the enzyme-degraded xyloglucan gels as vehicles for nasal delivery of drugs.

Tamarind Seed Xyloglucans Promote Proliferation and Migration of Human Skin Cells through Internalization via Stimulation of Proproliferative Signal Transduction Pathways

“…Tamarind xyloglucans are used in mucoadhesive buccal film [4], microspheres [5], hydrogels [6], and eyedrops [7]. Using tamarind xyloglucans improves percutaneous transport [8], regulates release [9], enhances bioavailability [8], and prolongs systemic absorption [5] of various drugs. Furthermore various investigations were done to lighten the activity of these special xyloglucans on different in vivo and in vitro models far of the traditional use against digestive disorders.…”

Stimuli-Responsive Hydrogels: An Interdisciplinary Overview

“…in aqueous media after gelation showed three-dimensional macroporous interconnected network with an elastic modulus which was significantly higher than other natural or synthetic hydrogels [111]. β-galactosidase-treated xyloglucan after being partially degraded (45% of galactose residues removed) formed thermoresponsive hydrogel at 27°C to work as drug delivery system for nasal drugs [111]. Xyloglucan-based thermoresponsive hydrogel was developed for delivery of lidocaine HCl in the treatment of periodontosis, and this in situ hydrogel-loaded with analgesic drug offered an alternative to painful injection therapy of anesthesia during dental surgery [112].…”

“…Xyloglucan (3%wt.) in aqueous media after gelation showed three-dimensional macroporous interconnected network with an elastic modulus which was significantly higher than other natural or synthetic hydrogels [111]. β-galactosidase-treated xyloglucan after being partially degraded (45% of galactose residues removed) formed thermoresponsive hydrogel at 27°C to work as drug delivery system for nasal drugs [111].…”

Nasal-nanotechnology: revolution for efficient therapeutics delivery

“…These systems are appears as liquids in storage conditions but converted to gels at the site of application. This conversion is triggered by the pH (Nakamura et al, 1999), temperature (Majithiya et al, 2006;Mahajan et al, 2012), presence of any other ionic or biological component, etc.…”