Thermo-mechanical properties of semi-degradable Poly(β-amino ester)-co-methyl methacrylate networks under simulated physiological conditions

Safranski, David L.; Crabtree, Jacob C.; Huq, Yameen; Gall, Ken

doi:10.1016/j.polymer.2011.08.033

Cited by 13 publications

(9 citation statements)

References 28 publications

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“…The samples tested under accelerated conditions disintegrated over a span of 20 weeks, where the highest timepoints experienced massive disintegration. The use of PEGDA‐based PBAE crosslinkers allows for rapid swelling and degradation; however, if a more hydrophobic PBAE was used, the swelling and degradation rate would be severely decreased 52. Further tailoring of degradation rate can be achieved either by mixing diacrylates within the PBAE composition or lower concentrations of PBAE 36…”

Section: Discussionmentioning

confidence: 99%

Biodegradable thermoset shape‐memory polymer developed from poly(β‐amino ester) networks

Lakhera

Laursen

Safranski

et al. 2012

J Polym Sci B Polym Phys

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The purpose of this study was to develop a degradable thermoset shape-memory polymer from poly(b-amino ester) (PBAE) networks. PBAE was chosen to be the crosslinker as it is biodegradable and has been projected as a potential material for biomedical applications. The low glass transition temperature of PBAE was increased to a biomedically relevant range using methyl methacrylate and methyl acrylate as the linear chain builders. The thermo-mechanical properties of the networks were tailored such that they exhibited onset of glass transition temperature in between the room temperature (22 C) and the body temperature (37 C). Free-strain recovery tests under heating and isothermal conditions were performed to quantify shape-memory behavior. Testing showed that sampled programmed at 10 C ini-tiated deformation recovery at a lower temperature and a faster rate as compared to programming at 60 C. Higher thermal conductivity of water enabled the samples to recover faster in water than in air. Samples with higher PBAE crosslinking densities exhibited higher normalized mass loss under regular and accelerated conditions. The amount of water absorption in the networks also increased with the crosslinker concentration independent of the testing conditions.

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Section: Discussionmentioning

confidence: 99%

Biodegradable thermoset shape‐memory polymer developed from poly(β‐amino ester) networks

Lakhera

Laursen

Safranski

et al. 2012

J Polym Sci B Polym Phys

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“…The PBAE macromers were mixed with MMA (45 wt% PBAE macromer: 55 wt% MMA) and 0.5 wt% Irgacure 2959. This solution was photopolymerized for 45 minutes under a UVP Blakray lamp (~10mW/cm 2 ) [32]. A Bruker Vector 22 FTIR with Pike Technologies Miracle ATR attachment with ZnSe crystal was used to characterize the chemical structure of the networks after photopolymerization.…”

Section: Methodsmentioning

confidence: 99%

“…Previous studies have separately examined the combinatorial characterization of PBAE networks and the thermo-mechanical properties of (meth)acrylates [18, 29]. Previous work has also demonstrated that by mixing with varying amounts of methyl methacrylate (MMA), the thermo-mechanical properties of hydrophobic PBAE networks can be tuned to increase Tg, increase toughness, and maintain a rubbery state [32]. However, the relationships between hydrophilicity and thermo-mechanical behavior have yet to be assessed throughout the degradation process.…”

Section: Introductionmentioning

confidence: 99%

“…Three biodegradable crosslinkers, poly(β-amino ester)s with acrylate endgroups, were synthesized with varying levels of hydrophilicity to alter mass loss rate [31, 33]. By combining them with a nondegradable, high Tg monomer, such as methyl methacrylate, the Tg of the network was increased to ambient conditions [32]. The biodegradable crosslinkers have shown previous biocompatibility in vivo , and PMMA is well known to be biocompatible [33–35].…”

Section: Introductionmentioning

confidence: 99%

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Semi-degradable poly(β-amino ester) networks with temporally controlled enhancement of mechanical properties

et al. 2014

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Biodegradable polymers are clinically used in numerous biomedical applications, and classically show a loss in mechanical properties within weeks of implantation. This work demonstrates a new class of semi-degradable polymers that show an increase in mechanical properties through degradation via a controlled shift in a thermal transition. Semi-degradable polymer networks, poly(β-amino ester)-co-methyl methacrylate, were formed from a low glass transition temperature crosslinker, poly(β-amino ester), and high glass transition temperature monomer, methyl methacrylate, which degraded in a manner dependent upon the crosslinker chemical structure. In vitro and in vivo degradation revealed changes in mechanical behavior due to the degradation of the crosslinker from the polymer network. This novel polymer system demonstrates a strategy to temporally control the mechanical behavior of polymers and to enhance the initial performance of smart biomedical devices.

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“…37 As can be seen from the results, LPBAEU-T2 and LPBAEU-A2 networks (D:A ratio of 1.4:1) showed the highest Tg values because of the reduction in chain mobility of these highly crosslinked structures. [50][51][52]…”

Section: Structural Characterization Of Lpbaeu Macromers and Networkmentioning

confidence: 99%

Lysine-derived, pH-sensitive and biodegradable poly(beta-aminoester urethane) networks and their local drug delivery behaviour

Tamer

Chen

2018

Soft Matter

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In this study, a series of covalently crosslinked, l-lysine based poly(beta-aminoester urethane) (LPBAEU) networks with good biodegradability and pH sensitivity was reported. The effect of hydrophilic/hydrophobic characteristics and diacrylate/amine molar ratio on the structure, swelling and degradation behaviour of the networks was investigated. The water transport mechanism and dynamic swelling behavior of the LPBAEU networks were strongly affected by medium pH, and swelling amounts up to 252.2% and 148.7% were observed at pH 5.6 and pH 7.4, respectively. It was found that water diffusion within the networks followed a non-Fickian mechanism. The LPBAEU network with the highest diacrylate/amine molar ratio exhibited the highest tensile strength and Young's modulus. In vitro mass losses of networks showed that the degradation rate of LPBAEU networks can be adjusted from 4 to 14 days. LPBAEU networks also supported loading of doxycycline hyclate (DH) and in vitro release studies demonstrated that release of DH from the networks was substantially hindered in the neutral pH environment, with 20.9-56.2% DH release, whereas DH release was accelerated under mild acidic conditions, with a release percentage of 36.6-99.6%. The release data were fitted to different mathematical models and the obtained results confirmed that these networks released DH in a non-Fickian mechanism. The results of this research support the idea that pH-responsive LPBAEU networks may find potential applications in local drug delivery.

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Thermo-mechanical properties of semi-degradable Poly(β-amino ester)-co-methyl methacrylate networks under simulated physiological conditions

Cited by 13 publications

References 28 publications

Biodegradable thermoset shape‐memory polymer developed from poly(β‐amino ester) networks

Biodegradable thermoset shape‐memory polymer developed from poly(β‐amino ester) networks

Semi-degradable poly(β-amino ester) networks with temporally controlled enhancement of mechanical properties

Lysine-derived, pH-sensitive and biodegradable poly(beta-aminoester urethane) networks and their local drug delivery behaviour

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