Thermo-sensitive graphene oxide–polymer nanoparticle hybrids: synthesis, characterization, biocompatibility and drug delivery

Self-assembled peptide nanofibers on graphene oxide as a novel nanohybrid for biomimetic mineralization of hydroxyapatite

“…It should have not only biocompatibility and certain mechanical strength, but also those capabilities for response to specific biological signals expressing and promoting cell attachment, proliferation, differentiation and finally tissue regeneration [13]. Graphene oxide (GO), as an amphiphile scaffold with a largely hydrophobic basal plane and hydrophilic edges [14], could be an ideal and promising nanoscale reinforcement material for bone tissue engineering due to its unique properties, including high mechanical strength, large specific surface area (2600 m 2 g À1 ), and good biocompatibility [15][16][17][18]. It is worth noting that the GO nanosheet is a monolayer of carbon atoms with dense honeycomb structures and contains numerous reactive oxygen functional groups, which could provide reactive sites for functionalization.…”

Influence of polyethylene glycol coating on biodistribution and toxicity of nanoscale graphene oxide in mice after intravenous injection

“…[6][7][8][9][10] Recently, NGO has been demonstrated to be an effective nanocarrier of anticancer drugs. [11][12][13][14] However, the in vivo distribution and toxicity of NGO, which would provide important supporting information to help determine its feasibility for potential biomedical applications, have rarely been evaluated.…”

Recent Advances in the Synthesis of Graphene-Based Nanomaterials for Controlled Drug Delivery

“…These processes facilitate the drug delivery. For instance, Wang et al, reported that the drug loading and release of the thermos-sensitive graphene oxide-polymer nanoparticles hybrid could be controlled by adjusting temperature [35]. …”

“…In Stimulation-responsive polymers could also be utilized to modify graphene for controlled drug delivery. With the aid of lower critical solution temperature of poly(N-isopropylacrylamide) (PNIPAM), Wang et al, synthesized PNIPAM-poly(ethylene oxide)-based polymer nanoparticles (PNPs) by free radical polymerization reaction and then assembled PNPs onto the 1-pyrenebutyric acid N-hydroxysuccinimide ester functionalized GO nanosheets [35], as shown in Figure 7. The obtained thermo-sensitive PNPs-GO nanohybrid had~87% of loading efficiency and 13-22% of release efficiency for adriamycin (ADR).…”