Thermo-sensitivity and erosion of chitosan crosslinked poly[N-isopropylacrylamide-co-(acrylic acid)-co-(methyl methacrylate)] hydrogels for application to the inferior fornix

Injectable hydrogel with dual-sensitive behavior for targeted delivery of oncostatin M to improve cardiac restoration after myocardial infarction

“…The collapse and aggregation of PNIPAM corona upon heating led to the formation of hydrogels with local hydrophobic domains. 38 As expected, 39 it can be seen from Fig. 1G that the lower critical solution temperature (LCST) increases with the amount of covalently conjugated CS, and the result shows that CS–CA–PNIPAM hydrogel possesses good temperature reactivity when CS : CA ratio is 3 : 1 and 2 : 1.…”

Aggressive strategies for regenerating intervertebral discs: stimulus-responsive composite hydrogels from single to multiscale delivery systems

“…28 In contrast, hydrophobic monomers such as methyl methacrylate (MMA) reduce the LCST of the polymer. 48 In addition, pNIPAAM- co -AA polymers have the potential to support hepatocyte activity and allow them to secrete substrates, 49 promising applications as delivery scaffolds for MSCs in regenerative IVD strategies.…”

“…46,47 Alternatively, the LCST can be altered by polymerization with other hydrophilic or hydrophobic monomers, e.g., acrylic acid (AA) increases the hydrophilicity of the copolymer and creates more hydrogen bonds with water, resulting in an increase in LCST and dehydration shrinkage at 43 1C. 48 Polymer chains with low AA content precipitate first, at which point the chains with higher AA content exhibit a nonprecipitated coiled or partially precipitated spherical shape, with coiled and spherical shapes. The polymer chains mix to form hydrophobic aggregates, at which point solubilization does not occur when water is added to the pNIPAAM-co-AA polymer.…”

Smart Injectable Chitosan Hydrogels Loaded with 5-Fluorouracil for the Treatment of Breast Cancer

“…Glycosaminoglycan has been employed in injectable hydrogels due to its antibacterial, biocompatible, biodegradable, and mucoadhesive qualities [ 18 ]. The mucoadhesive and in situ Cs gel-forming properties can be used to sustain the delivery of both hydrophilic and hydrophobic drugs [ 19 ].…”