Thermoacoustic Lensing in Ultrasound Imaging of Nonechogenic Tissue During High-intensity Focused Ultrasound Exposure

Jahns, Matthew; MacDougall, Dan; Adamson, Robert

doi:10.1177/0161734617752477

Cited by 2 publications

(2 citation statements)

References 36 publications

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“…The artifacts become more evident with the increase of temperature. This issue results from the so‐called thermos‐acoustic lens effect . The localized heated region in the phantom acts like a “lens” which refracts the transmitted ultrasound beams of the imaging probe, because the sound speed within the heated region is changed.…”

Section: Discussionmentioning

confidence: 99%

“…This issue results from the so-called thermosacoustic lens effect. 28,29,54 The localized heated region in the phantom acts like a "lens" which refracts the transmitted ultrasound beams of the imaging probe, because the sound speed within the heated region is changed. This would result in the decorrelation of ultrasound RF signals in the deeper region, especially below the heated region, as shown in [ Fig.…”

Section: B Design For Reducing the Viscous Heating Artifact Of Thementioning

confidence: 99%

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Evaluating HIFU‐mediated local drug release using thermal strain imaging: Phantom and preliminary in‐vivo studies

Lee

Gao

et al. 2019

Medical Physics

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Purpose High‐intensity focused ultrasound (HIFU)‐mediated drug release becomes a promising therapeutic technique for treatment of cancer, which has merits of deep penetration, noninvasive approach and nonionizing radiation. However, conventional thermocouple‐based approach for treatment monitoring would encounter big challenges such as the viscous heating artifact and difficulty in monitoring in the deep region. In this study, we develop an effective method based on thermal strain imaging (TSI) for the evaluation of HIFU‐mediated drug release. Methods Both phantom experiments and preliminary animal experiments were performed to investigate the feasibility of the proposed approach. Doxorubicin (DOX)‐loaded cerasomes (HIFU and temperature‐sensitive cerasomes, HTSCs) were prepared. In the phantom experiments, the HTSC solution is contained inside a cylindrical chamber within a tissue‐mimicking phantom. In the animal experiments, the HTSCs are intravenously injected into tumor‐bearing mice. An HIFU transducer is used to trigger DOX release from the HTSCs within the phantom or mice, and TSI is performed during HIFU heating. In the phantom experiments, the accuracy of temperature estimation using TSI is validated by measuring with a thermocouple. In animal experiments, the spatial consistency between the distribution of DOX released within the tumor and the location of the heating region estimated by TSI is validated using a spectrofluorophotometer. Results In the phantom experiments, the HTSCs show a burst release of DOX when the temperature of the HTSC solution estimated by TSI reaches about 42°C, which is in agreement with the condition for drug release from the HTSCs. The temperature estimation using TSI has high accuracy with error below 2.5%. In animal experiments, fluorescence imaging of the tumor validates that the heating region of HIFU could be localized by the low‐strain region of TSI. Conclusion The present framework demonstrates a reliable and effective solution to the evaluation of HIFU‐mediated local drug delivery.

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Section: Discussionmentioning

confidence: 99%

Section: B Design For Reducing the Viscous Heating Artifact Of Thementioning

confidence: 99%

Evaluating HIFU‐mediated local drug release using thermal strain imaging: Phantom and preliminary in‐vivo studies

Lee

Gao

et al. 2019

Medical Physics

View full text Add to dashboard Cite

show abstract

Ultrasound Delta CBE Imaging: A New Approach Based on Local Energy Subtraction to Localization of the HIFU Focal Spot Using Changes in Backscattered Energy

Yang,

Li,

Zhou

et al. 2024

J. Med. Biol. Eng.

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Thermoacoustic Lensing in Ultrasound Imaging of Nonechogenic Tissue During High-intensity Focused Ultrasound Exposure

Cited by 2 publications

References 36 publications

Evaluating HIFU‐mediated local drug release using thermal strain imaging: Phantom and preliminary in‐vivo studies

Evaluating HIFU‐mediated local drug release using thermal strain imaging: Phantom and preliminary in‐vivo studies

Ultrasound Delta CBE Imaging: A New Approach Based on Local Energy Subtraction to Localization of the HIFU Focal Spot Using Changes in Backscattered Energy

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