Thermocapillary Actuation of Millimeter-Scale Rotary Structures

Hendarto, E.; Gianchandani, Yogesh B.

doi:10.1109/jmems.2013.2281328

Cited by 8 publications

(6 citation statements)

References 23 publications

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“…A decrease in the spectral profile of DCD‐SERS signals from the ring zone to the center zone is a result of changes in the capillary flow rate during evaporation (Gorr et al ; Hendarto and Gianchandani, ; Marín et al, ). The high intensity Raman signals in the ring zone indicate that this could be the ideal location for optical DCD‐SERS detection of HPV infection in cervical biofluids.…”

Section: Discussionmentioning

confidence: 99%

Biochemical investigations of human papillomavirus‐infected cervical fluids

Choi

Park

Min

et al. 2014

Microscopy Res & Technique

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Section: Discussionmentioning

confidence: 99%

Biochemical investigations of human papillomavirus‐infected cervical fluids

Choi

Park

Min

et al. 2014

Microscopy Res & Technique

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“…Thermocapillary-based microdevices as discussed in this section can be categorized in general groups of pumps and actuators, mixers, valves, switches, and traps, and also sensors; although thermocapillarity has also been used in small scale for other purposes. Using Marangoni convection for manipulation of solid microbeads by Vela et al [ 210 ], employing thermocapillarity for shaft work production by Hendarto and Gianchandani [ 211 ], and analog chemical computation by Lovass et al [ 212 ] are some of these examples.…”

Section: Device Applicationsmentioning

confidence: 99%

Thermocapillarity in Microfluidics—A Review

2016

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This paper reviews the past and recent studies on thermocapillarity in relation to microfluidics. The role of thermocapillarity as the change of surface tension due to temperature gradient in developing Marangoni flow in liquid films and conclusively bubble and drop actuation is discussed. The thermocapillary-driven mass transfer (the so-called Benard-Marangoni effect) can be observed in liquid films, reservoirs, bubbles and droplets that are subject to the temperature gradient. Since the contribution of a surface tension-driven flow becomes more prominent when the scale becomes smaller as compared to a pressure-driven flow, microfluidic applications based on thermocapillary effect are gaining attentions recently. The effect of thermocapillarity on the flow pattern inside liquid films is the initial focus of this review. Analysis of the relation between evaporation and thermocapillary instability approves the effect of Marangoni flow on flow field inside the drop and its evaporation rate. The effect of thermocapillary on producing Marangoni flow inside drops and liquid films, leads to actuation of drops and bubbles due to the drag at the interface, mass conservation, and also gravity and buoyancy in vertical motion. This motion can happen inside microchannels with a closed multiphase medium, on the solid substrate as in solid/liquid interaction, or on top of a carrier liquid film in open microfluidic systems. Various thermocapillary-based microfluidic devices have been proposed and developed for different purposes such as actuation, sensing, trapping, sorting, mixing, chemical reaction, and biological assays throughout the years. A list of the thermocapillary based microfluidic devices along with their characteristics, configurations, limitations, and improvements are presented in this review.

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“…B). This effect is responsible for the capillary effect during evaporation (Choi et al, ; Hendarto and Gianchandani, ). Since high Raman intensity was measured from the ring zone, this might be the ideal position for label‐free optical screening of HPV infection in cervical fluids.…”

Section: Resultsmentioning

confidence: 99%

Biochemical fingerprints of human papillomavirus infection and cervical dysplasia using cervical fluids: Spectral pattern investigation

Kim

Chang

Choi

et al. 2016

Microsc. Res. Tech.

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The Pap smear is the primary screening tool for invasive cervical cancer resulting from a persistent infection with oncogenic human papillomavirus (HPV); however, there are the problems such as the inability to distinguish between HPV infection and cervical dysplasia and a low sensitivity remain. We present preliminary findings of a label-free method to detect and classify HPV infection and cervical dysplasia using human cervical fluids. Three experimental groups, defined as normal, HPV-positive, and cervical dysplasia, were evaluated through their Raman spectral patterns for noise-independence, high reproducibility, and uniformity. Clinical diagnosis was performed through liquid-based cervical cytology, HPV test, and cervical histologic examination. Healthy cervical fluids showed a strong Raman intensity at 877 cm (symmetric C-C stretching), and at 963 cm (phosphate), compared to a reference Raman peak at 1003 cm (phenylalanine symmetric ring breath). The HPV-positive cervical fluids showed a strong intensity of a Raman peak at 1448 cm corresponding to C-H deformation vibration mode and the highest similarity between the central and ring zones among the three groups. The cervical dysplasia fluids showed the presence of strong peaks compared to the control and HPV-positive groups. In addition, different Raman spectra were acquired according to HPV type. Therefore, all ranges of cervical fluid-induced Raman spectra could be used to detect the presence of cervical pre-cancer. Raman peak-gated assessment provides a label-free and nondestructive tool for the clinical diagnosis of HPV infection and cervical precancerous changes.

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Thermocapillary Actuation of Millimeter-Scale Rotary Structures

Cited by 8 publications

References 23 publications

Biochemical investigations of human papillomavirus‐infected cervical fluids

Biochemical investigations of human papillomavirus‐infected cervical fluids

Thermocapillarity in Microfluidics—A Review

Biochemical fingerprints of human papillomavirus infection and cervical dysplasia using cervical fluids: Spectral pattern investigation

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