Thermodynamic and Spectroscopic (UV–Vis, FT IR) Studies of Solutions of CoCl2 (or NiCl2) in Diethylsulfoxide

Markarian, Shiraz A.; Ghazoyan, Heghine H.; Sargsyan, Hasmik R.; Shahinyan, Gohar A.

doi:10.1007/s10953-019-00924-9

Cited by 9 publications

(2 citation statements)

References 38 publications

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“…These bands display medium to weak molar extinction coefficients and are in the expected region for similar complexes [52]. For the cobalt(II) complex 2, the very low intensity and rather broad absorption, centered at ~680 nm can be attributed to d-d transitions [53]. Also for the copper(II) complex 3, the broad absorption band in the range of 660-870 nm, is attributed to d-d transition [54].…”

Section: Solution Behavior (Conductivity Measurements Uv-vis Spectros...mentioning

confidence: 74%

First-Row Transition Metal Complexes Incorporating the 2-(2′-pyridyl)quinoxaline Ligand (pqx), as Potent Inflammatory Mediators: Cytotoxic Properties and Biological Activities against the Platelet-Activating Factor (PAF) and Thrombin

Margariti,

Papakonstantinou,

Stamatakis

et al. 2023

Molecules

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Inflammatory mediators constitute a recently coined term in the field of metal-based complexes with antiplatelet activities. Our strategy targets Platelet-Activating Factor (PAF) and its receptor, which is the most potent lipid mediator of inflammation. Thus, the antiplatelet (anti-PAF) potency of any substance could be exerted by inhibiting the PAF-induced aggregation in washed rabbit platelets (WRPs), which internationally is a well-accepted methodology. Herein, a series of mononuclear (mer-[Cr(pqx)Cl3(H2O]) (1), [Co(pqx)Cl2(DMF)] (2) (DMF = N,N′-dimethyl formamide), [Cu(pqx)Cl2(DMSO)] (3) (DMSO = dimethyl sulfoxide), [Zn(pqx)Cl2] (4)) and dinuclear complexes ([Mn(pqx)(H2O)2Cl2]2 (5), [Fe(pqx)Cl2]2 (6) and [Ni(pqx)Cl2]2 (7)) incorporating the 2-(2′-pyridyl)quinoxaline ligand (pqx), were biologically evaluated as inhibitors of the PAF- and thrombin-induced aggregation in washed rabbit platelets (WRPs). The molecular structure of the five-co-ordinate analog (3) has been elucidated by single-crystal X-ray diffraction revealing a trigonal bipyramidal geometry. All complexes are potent inhibitors of the PAF-induced aggregation in WRPs in the micromolar range. Complex (6) displayed a remarkable in vitro dual inhibition against PAF and thrombin, with IC50 values of 1.79 μM and 0.46 μM, respectively. Within the series, complex (5) was less effective (IC50 = 39 μM) while complex (1) was almost 12-fold more potent against PAF, as opposed to thrombin-induced aggregation. The biological behavior of complexes 1, 6 and 7 on PAF’s basic metabolic enzymatic pathways reveals that they affect key biosynthetic and catabolic enzymes of PAF underlying the anti-inflammatory properties of the relevant complexes. The in vitro cytotoxic activities of all complexes in HEK293T (human embryonic kidney cells) and HeLa cells (cervical cancer cells) are described via the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. The results reveal that complex 3 is the most potent within the series.

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Section: Solution Behavior (Conductivity Measurements Uv-vis Spectros...mentioning

confidence: 74%

First-Row Transition Metal Complexes Incorporating the 2-(2′-pyridyl)quinoxaline Ligand (pqx), as Potent Inflammatory Mediators: Cytotoxic Properties and Biological Activities against the Platelet-Activating Factor (PAF) and Thrombin

Margariti,

Papakonstantinou,

Stamatakis

et al. 2023

Molecules

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“…Similar absorbances in the 600–700 nm range have been previously assigned to tetrahedral coordination of CoCl 2 with other ligands such as nitrate and diethyl sulfoxide. 46–48 The similarity of the UV-vis spectra in the 500–800 nm range for all [Pam- co -PDADMA][Co 2+ ] and [Pam- co -PDADMA][mixed Fe 3+ /Co 2+ ] copolymers indicates that the cobalt complex structure forms similarly for all mole equivalences.…”

Section: Resultsmentioning

confidence: 96%

Influence of metal-coordinating comonomers on the coordination structure and binding in magnetic poly(ionic liquid)s

Foley

Condes

Feugang

2023

Mol. Syst. Des. Eng.

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Short‐Time and High‐Performance Recovery of Critical Metal Elements From Spent Ternary Lithium‐Ion Batteries by Selective Synergic Coordination Effect

Liu,

Yan,

Xin

et al. 2024

Adv Funct Materials

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Recycling of spent ternary lithium‐ion batteries (LIBs) is crucial for both resource recovery and environmental sustainability. Deep eutectic solvents (DESs), as an eco‐friendly leaching agent, offer a promising alternative to mineral acids for the metal recovery. However, current DES‐based systems primarily focus on binary LiCoO2 batteries and suffer from complex leaching conditions, including high operation temperature, long reaction time. Herein, a dual‐function green solution is synthesized using choline chloride and tartaric acid, enabling direct precipitation of nickel (Ni) and separation of cobalt (Co), manganese (Mn), and lithium (Li) within 50 min at 100 °C, without requiring additional reducing agents throughout the process. The recovery efficiency of Li, Ni, Co, and Mn reached 99.2%, 97.3%, 94.4%, and 94.1%, respectively, while the purity of Ni products approached 99.9%. The used system is suitable for recycling various types of ternary batteries. Additionally, both theoretical and experimental analyses reveal that Ni ions exhibit superior binding energy and coordination with DESs compared to other ions, attributed to the synergistic effect of strong interaction and stable chelation. This research offers a promising method for the replenishment of essential metal resources.

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Thermodynamic and Spectroscopic (UV–Vis, FT IR) Studies of Solutions of CoCl2 (or NiCl2) in Diethylsulfoxide

Cited by 9 publications

References 38 publications

First-Row Transition Metal Complexes Incorporating the 2-(2′-pyridyl)quinoxaline Ligand (pqx), as Potent Inflammatory Mediators: Cytotoxic Properties and Biological Activities against the Platelet-Activating Factor (PAF) and Thrombin

First-Row Transition Metal Complexes Incorporating the 2-(2′-pyridyl)quinoxaline Ligand (pqx), as Potent Inflammatory Mediators: Cytotoxic Properties and Biological Activities against the Platelet-Activating Factor (PAF) and Thrombin

Influence of metal-coordinating comonomers on the coordination structure and binding in magnetic poly(ionic liquid)s

Short‐Time and High‐Performance Recovery of Critical Metal Elements From Spent Ternary Lithium‐Ion Batteries by Selective Synergic Coordination Effect

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