Thermodynamic models for determination of the solid–liquid equilibrium of oxytocin in (acetonitrile+acetone) binary solvent mixtures

Zhang, Qi; Hu, Yonghong; Shen, Fei; Yang, Wenge; Wu, Gang; Gu, Pengfei; Yu, Yemin

doi:10.1016/j.fluid.2015.08.009

Cited by 2 publications

(1 citation statement)

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“…In order to correlate with the experimental data, we adopted the modified Apelblat equation, the CNIBS/R-K equations and the simplified Jouyban–Acree equation. In addition, the van’t Hoff analysis was used to understand the thermodynamic properties of the esomeprazole sodium, containing with the entropy, enthalpy, and Gibbs energy …”

Section: Introductionmentioning

confidence: 99%

Determination and Thermodynamic Modeling of Solid–Liquid Phase Equilibrium for Esomeprazole Sodium in Monosolvents and in the (Ethanol + Ethyl Acetate) Binary Solvent Mixtures

2017

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Esomeprazole sodium was a proton pump inhibitor (PPI) synthesized using omeprazole sulfide. In this paper, we used a static-analytic method to analyze the solubility of our own synthesis of esomeprazole sodium in ethyl acetate, acetonitrile, methyl isobutyl ketone, ethanol, methanol, and in the (ethanol + ethyl acetate) mixtures between 278.15 and 328.15 K. A group of thermodynamic models were selected such as the Jouyban−Acree equation, the modified Apelblat equation, and CNIBS/R-K equations. All equations can be well applied and the modified Apelblat equations are relatively better. We determined the thermodynamic properties of esomeprazole sodium using the van't Hoff equation furthermore, including the entropy, Gibbs energy, and enthalpy.

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Section: Introductionmentioning

confidence: 99%