Thermodynamic Properties of Matrine in Ethanol

Abstract

In this paper, the enthalpies of dissolution of matrine in ethanol (EtOH) were measured using a RD496-2000 Calvet microcalorimeter at 309.65 K under atmospheric pressure. The differential enthalpy ( dif H m ) and molar enthalpy ( sol H m ) of dissolution of matrine in ethanol were determined. And the relationship between heat and the amount of solute was also established. Based on the thermodynamic and kinetic knowledge, the corresponding kinetic equation that described the dissolution process was determined to be dα dt = 2.36 × 10 −4 (1 − α) 1.09 . Moreover, the half-life, t 1/2 = 48.89 min, sol H m = −12.40 kJ · mol −1 , sol S m = −354.7 J · mol −1 · K −1 , and sol G m = 97.43 kJ · mol −1 of the dissolution process were also obtained. The results show that this work not only provides a simple method for the determination of the half-life for a drug but also offers a theoretical reference for the clinical application of matrine.

Adsorption of Berberine Hydrochloride, Ligustrazine Hydrochloride, Colchicine, and Matrine Alkaloids on Macroporous Resins

“…Berberine hydrochloride has a variety of pharmacological effects such as anticancer action, antibiotic property, and anti-inflammatory effect. , Ligustrazine hydrochloride is widely used to cure cardiovascular diseases in China . Colchicines is used for the treatment of acute gout flares and the prophylaxis of gout flares, and matrine has a wide spectrum of pharmacological actions including hepatoprotective activity on acetaminophen-induced hepatotoxicity in mice, and proapoptotic activity in gastric carcinoma cells and leukemia cells …”