Based on the Biot's wave equation and theory of thermodynamic, Darcy law of fluid and the modified Fourier law of heat conduction, a nonlinear fully coupled thermo-hydro-elastodynamic response model (THMD) for saturated porous medium is derived. The compressibility of the medium, the influence of fluid flux on the heat flux, and the influence of change of temperature on the fluid flux are considered in this model. With some simplification, the coupled nonlinear thermo-hydro-elastodynamic response model can be reduced to the thermo-elastodynamic (TMD) model based on the traditional Fourier law and, further more, to the Biot's wave equation without considering the heat phase. At last, the problem of one dimensional cylindrical cavity subjected to a time-dependent thermal/mechanical shock is analyzed by using the Laplace technique, the numerical results are used to discuss the influence of Biot's modulus M and coefficient of thermo-osmosis on displacement and to compare with the results of thermo-elastodynamic response to ascertain the validity of this model. nonlinear, thermo-hydro-elastodynamic, dynamic response, laplace transform