Thermogenic Effect of Progesterone

Barton, Mary Kay; Wiesner, B. P.

doi:10.1016/s0140-6736(45)91388-2

Cited by 58 publications

(18 citation statements)

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“…Endogenous estradiol and progesterone modulate thermoregulation. Systemic progesterone increases core temperature, 1,2 decreases the firing rate of preoptic warm sensitive neurons, and increases the firing rate of preoptic cold sensitive neurons 3 . These observations support an upward shift in the thermoregulatory set‐point and higher regulated body temperature 4 .…”

supporting

confidence: 55%

Resetting the Thermoregulatory Set‐Point by Endogenous Estradiol or Progesterone in Women

Kolka

Stephenson

1997

Annals of the New York Academy of Sciences

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supporting

confidence: 55%

Resetting the Thermoregulatory Set‐Point by Endogenous Estradiol or Progesterone in Women

Kolka

Stephenson

1997

Annals of the New York Academy of Sciences

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“…In humans, it is generally recognized that E 2 decreases body temperature by enhancing effector responses (i.e., sudomotor and vasomotor) and heat loss (31). Conversely, systemic P 4 increases core temperature (6), suggesting an upward shift in the thermoregulatory set point (24). These observations agree with the known changes of E 2 , P 4 , and body temperature during the human menstrual cycle.…”

supporting

confidence: 82%

Heat acclimation and physical training adaptations of young women using different contraceptive hormones

Armstrong¹,

Maresh²,

Keith³

et al. 2005

American Journal of Physiology-Endocrinology and Metabolism

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Although endogenous and exogenous steroid hormones affect numerous physiological processes, the interactions of reproductive hormones, chronic exercise training, and heat acclimation are unknown. This investigation evaluated the responses and adaptations of 36 inactive females [age 21 +/- 3 (SD) yr] as they undertook a 7- to 8-wk program [heat acclimation and physical training (HAPT)] of indoor heat acclimation (90 min/day, 3 days/wk) and outdoor physical training (3 days/wk) while using either an oral estradiol-progestin contraceptive (ORAL, n = 15), a contraceptive injection of depot medroxyprogesterone acetate (DEPO, n = 7), or no contraceptive (EU-OV, n = 14; control). Standardized physical fitness and exercise-heat tolerance tests (36.5 degrees C, 37% relative humidity), administered before and after HAPT, demonstrated that the three subject groups successfully (P < 0.05) acclimated to heat (i.e., rectal temperature, heart rate) and improved muscular endurance (i.e., sit-ups, push-ups, 4.6-km run time) and body composition characteristics. The stress of HAPT did not disrupt the menstrual cycle length/phase characteristics, ovulation, or plasma hormone concentrations of EU-OV. No between-group differences (P > 0.05) existed for rectal and skin temperatures or metabolic, cardiorespiratory, muscular endurance, or body composition variables. A significant difference post-HAPT in the onset temperature of local sweating, ORAL (37.2 +/- 0.4 degrees C) vs. DEPO (37.7 +/- 0.2 degrees C), suggested that steroid hormones influenced this adaptation. In summary, virtually all adaptations of ORAL and DEPO were similar to EU-OV, suggesting that exogenous reproductive hormones neither enhanced nor impaired the ability of women to complete 7-8 wk of strenuous physical training and heat acclimation.

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“…81,87,88 In studies where increases in EE have been registered, a concomitant increase in progesterone or its metabolic product in urine, pregnandiol (indicating an elevated level of secreted progesterone), has been measured. 87,88 Additionally, progesterone has been shown to be hyperthermic both in normal and in ovariectomized women, 95,96 possibly mediated by a direct influence on the thermoregulatory center in the hypothalamus. 97 This suggests that progesterone is a general metabolic stimulator.…”

Section: Resting Metabolic Rate and 24-h Energy Expenditurementioning

confidence: 99%

Impact of the menstrual cycle on determinants of energy balance: a putative role in weight loss attempts

2007

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Women's weight and body composition is significantly influenced by the female sex-steroid hormones. Levels of these hormones fluctuate in a defined manner throughout the menstrual cycle and interact to modulate energy homeostasis. This paper reviews the scientific literature on the relationship between hormonal changes across the menstrual cycle and components of energy balance, with the aim of clarifying whether this influences weight loss in women. In the luteal phase of the menstrual cycle it appears that women's energy intake and energy expenditure are increased and they experience more frequent cravings for foods, particularly those high in carbohydrate and fat, than during the follicular phase. This suggests that the potential of the underlying physiology related to each phase of the menstrual cycle may be worth considering as an element in strategies to optimize weight loss. Studies are needed to assess the weight loss outcome of tailoring dietary recommendations and the degree of energy restriction to each menstrual phase throughout a weight management program, taking these preliminary findings into account.

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Thermogenic Effect of Progesterone

Cited by 58 publications

References 0 publications

Resetting the Thermoregulatory Set‐Point by Endogenous Estradiol or Progesterone in Women

Resetting the Thermoregulatory Set‐Point by Endogenous Estradiol or Progesterone in Women

Heat acclimation and physical training adaptations of young women using different contraceptive hormones

Impact of the menstrual cycle on determinants of energy balance: a putative role in weight loss attempts

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