Thermoradiotherapy of Choroidal Melanoma

Finger, Paul T.; Packer, Samuel; Paglione, R.W.; Gatz, Joseph F.; Ho, Tony K.; Bosworth, Jay L.

doi:10.1016/s0161-6420(89)32735-7

Cited by 45 publications

(8 citation statements)

References 21 publications

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“…41 Several methods have been used to heat choroidal tumors. Finger et al 47 used a microwave heat delivery system in a clinical trial of 18 patients in 1989. Lasers have also been used to photocoagulate tumor cells at temperatures of more than 60°C.…”

Section: Elevation Of Tissue Temperaturementioning

confidence: 99%

Choroidal Melanoma: Natural History and Management Options

Bell

Wilson

2004

Cancer Control

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Section: Elevation Of Tissue Temperaturementioning

confidence: 99%

Choroidal Melanoma: Natural History and Management Options

Bell

Wilson

2004

Cancer Control

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“…Irradiation treatment meets with failures and complications such as radiation retinopathy. To enhance its effect it has been combined with low range hyperthermia at 42-44 ~ which in itself has no direct cell killing effect [2,3].…”

Section: Introductionmentioning

confidence: 99%

Transpupillary thermotherapy (TTT) by infrared irradiation of choroidal melanoma

et al. 1992

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We studied the destructive effect of hyperthermia at sub-photocoagulation level of 45-60 degrees C on melanomas. Optimal conditions for spreading of heat into tissue are a wavelength of 700-900 nm, a temperature of 45-60 degrees C, an exposure time of 1 minute or more, and a beam diameter of several millimeters. In hamsters with subcutaneous melanomas we obtained a tumour necrosis of 6 mm depth at 60 degrees C and one minute exposure time. We performed transpupillary thermotherapy (TTT) with a diode laser at 810 nm in patients with choroidal melanomas prior to enucleation. Treatment is based on the fortunate situation that irradiation at this wavelength combines optimal tissue penetration with a low absorption by clear ocular media of 5% or less. In 3 TTT-treated eyes histopathology showed a depth of necrosis of 0.9, 3.4, and 3.9 mm. TTT may become a new useful treatment modality for choroidal melanoma but its ultimate value has yet to be assessed.

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“…The etching process selectively left a 2 mm free margin between the copper disc and the edge of the antenna (Fig 1). 20 26 A short length of flexible silicone-covered coaxial cable AS 450-3650 SR (Cooner Wire, Chatsworth, CA, USA) was used to direct the microwave energy from the microwave generator/ amplifier to the patch antenna. The silicone coating was removed at one end which exposed the centre conductor.…”

Section: Microwave Thermotherapymentioning

confidence: 99%

Microwave plaque thermoradiotherapy for choroidal melanoma.

Finger

1992

British Journal of Ophthalmology

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Microwave thermoradiotherapy was used as a primary treatment for 44 patients with choroidal melanoma. An episcleral dishshaped microwave antenna was placed beneath the tumour at the time of plaque brachytherapy. While temperatures were measured at the sclera, the tumour's apex was targeted to receive a minimum of 42°C for 45 minutes. In addition, the patients received full or reduced doses of plaque radiotherapy. No patients have been lost to foliow-up. Two eyes have been enucleated: one for rubeotic glaucoma, and one for uveitic glaucoma. Though six patients have died, only one death was due to metastatic choroidal melanoma (39 months after treatment). Clinical observations suggest that the addition of microwave heating to plaque radiation therapy of choroidal melanoma has been weli tolerated. There has been a 97-7% local control rate (with a mean follow-up of 22.2 months). We have reduced the minimum tumour radiation dose (apex dose) to levels used for thermoradiotherapy of cutaneous melanomas (50 Gy/5000 rad). Within the range of this foliow-up period no adverse effects which might preclude the use of this microwave heat delivery system for treatment of choroidal melanoma have been noted.

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Thermoradiotherapy of Choroidal Melanoma

Cited by 45 publications

References 21 publications

Choroidal Melanoma: Natural History and Management Options

Choroidal Melanoma: Natural History and Management Options

Transpupillary thermotherapy (TTT) by infrared irradiation of choroidal melanoma

Microwave plaque thermoradiotherapy for choroidal melanoma.

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