Thermoradiotherapy of recurrent malignant brain tumors

Sneed, Penny K.; Gutin, Philip H.; Stauffer, Paul R.; Phillips, Theodore L.; Prados, Michael D.; Weaver, Keith A.; Suen, Stuart; Lamb, Sharon; Ham, Brigid; Ahn, David K.; Lamborn, Kathleen R.; Larson, David A.; Wara, William M.

doi:10.1016/0360-3016(92)90659-6

Cited by 82 publications

(41 citation statements)

References 30 publications

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“…Note that there were eight dogs (four in each thermal dose group) that did not finish all planned hyperthermia treatments due to various reasons. The median (interquartile range) number of temperature points was 21 (16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27). There was excellent temperature discrimination between thermal dose groups (Fig.…”

Section: Resultsmentioning

confidence: 98%

“…Hyperthermia treatments were constrained to last between 12 and 120 minutes, depending on the rate of thermal dose acquisition. Based on evidence that 5 CEM43jCT90 is necessary for improvement in tumor response compared with radiation alone (21,22), doses in this study were chosen to be above and below that value. A large difference between total doses was selected to avoid dose overlap between groups.…”

Section: Methodsmentioning

confidence: 99%

“…Descriptors of the lower end of the temperature distribution in tumors have been shown to have the most relevance to tumor response (8,18,20,21). In 1993 the quantification unit CEM43jCT90 was proposed to characterize the low end of the temperature distribution and also to incorporate duration of treatment (22).…”

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confidence: 99%

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Thermal Dose Is Related to Duration of Local Control in Canine Sarcomas Treated with Thermoradiotherapy

Thrall

LaRue

Yu³

et al. 2005

Clinical Cancer Research

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Purpose:To test that prospective delivery of higher thermal dose is associated with longer tumor control duration. Experimental Design: 122 dogs with a heatable soft tissue sarcoma were randomized to receive a low (2-5 CEM43jCT90) or high (20-50 CEM43jCT90) thermal dose in combination with radiotherapy. Most dogs (90%) received four to six hyperthermia treatments over 5 weeks. Results: In the primary analysis, median (95% confidence interval) duration of local control in the low-dose group was1.2 (0.7-2.1) years versus1.9 (1.4-3.2) years in the high-dose group (log-rank P = 0.28). The probability (95% confidence interval) of tumor control at 1 year in the low-dose versus high-dose groups was 0.57 (0.43-0.70) versus 0.74 (0.62-0.86), respectively. Using multivariable procedure, thermal dose group (P = 0.023), total duration of heating (P = 0.008), tumor volume (P = 0.041), and tumor grade (P = 0.027) were significantly related to duration of local tumor control. When correcting for volume, grade, and duration of heating, dogs in the low-dose group were 2.3 times as likely to experience local failure. Conclusions: Thermal dose is directly related to local control duration in irradiated canine sarcomas. Longer heating being associated with shorter local tumor control was unexpected. However, the effect of thermal dose on tumor control was stronger than for heating duration. The heating duration effect is possibly mediated through deleterious effects on tumor oxygenation. These results are the first to show the value of prospectively controlled thermal dose in achieving local tumor control with thermoradiotherapy, and they establish a paradigm for prescribing thermoradiotherapy and writing a thermal prescription.

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Section: Resultsmentioning

confidence: 98%

Section: Methodsmentioning

confidence: 99%

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Thermal Dose Is Related to Duration of Local Control in Canine Sarcomas Treated with Thermoradiotherapy

Thrall

LaRue

Yu³

et al. 2005

Clinical Cancer Research

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“…Since the efficacy of PDT depends, in part, on the ability to deliver adequate light doses to malignant cells in the resection margin, intraoperative treatment is unlikely to be effective due to the inability to deliver threshold light doses in a reasonable time period [8,9]. HT, the elevation of tissue temperature to at least 42°C, has been used in combination with other treatment modalities in therapy for brain tumors [10,11]. HT kills cells as a function of temperature and time, inhibits repair of sub-lethal damage and makes hypoxic cells more vulnerable to radiation or PDT [12,13].…”

Section: Introductionmentioning

confidence: 99%

Enhanced cytotoxic effects of 5-aminolevulinic acid-mediated photodynamic therapy by concurrent hyperthermia in glioma spheroids

et al. 2004

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“…There has been much interest in studying the effects of heat on the brain (Sminia et al, 1994;Haveman et al, 2005). A number of well-localized, mainly interstitial, invasive hyperthermia combination therapies have been applied for gliomas (Tanaka et al, 1987;Sneed et al, 1991Sneed et al, , 1992Sneed et al, , 1998Stea et al, 1990Stea et al, , 1994Moran et al, 1995;Fiorentini et al, 2006;Silva et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Hyperthermia Promotes Apoptosis and Suppresses Invasion in C6 Rat Glioma Cells

Wang

Zhang²,

Chen³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Gliomas are a group of heterogeneous primary central nervous system tumors. Hyperthermia has proven to be a potential therapeutic tool for cancers in the clinic. However, the molecular mechanisms of hyperthermia remain unclear. The objective of this study was to investigate the effects of hyperthermia on the invasiveness in C6 glioma cells and related molecular pathways. Here our data show hyperthermia stimulated the release of tumor necrosis factor-alpha (TNF-α) and decreased C6 glioma cell migration and invasive capability at 30, 60, 120 and 180 min; with increased spontaneous apoptosis in C6 glioma cells at 120 min. We also found mitogenactivated protein kinase (P38 MAPK) protein expression to be increased and nuclear factor-kappa B (NF-κB) protein expression decreased. Based on the results, we conclude that hyperthermia alone reduced invasion of C6 glioma cells through stimulating TNF-α signaling to activate apoptosis, enhancing P38 MAPK expression and inhibiting the NF-κB pathway, a first report in C6 rat glioma cells.

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Thermoradiotherapy of recurrent malignant brain tumors

Cited by 82 publications

References 30 publications

Thermal Dose Is Related to Duration of Local Control in Canine Sarcomas Treated with Thermoradiotherapy

Thermal Dose Is Related to Duration of Local Control in Canine Sarcomas Treated with Thermoradiotherapy

Enhanced cytotoxic effects of 5-aminolevulinic acid-mediated photodynamic therapy by concurrent hyperthermia in glioma spheroids

Hyperthermia Promotes Apoptosis and Suppresses Invasion in C6 Rat Glioma Cells

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