Thermoregulation in mice exhibits genetic variability early in senescence

Gonzales, Patrick; Rikke, Brad A.

doi:10.1007/s11357-009-9109-0

Cited by 7 publications

(4 citation statements)

References 42 publications

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“…This response is believed to be under genetic control and to have evolved as a mechanism to save energy, prolonging survival until more food becomes available [8,9]. The molecules and the signals that are involved in regulating this physiological adaptation are beginning to be identified [10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Gonadal hormones influence core body temperature during calorie restriction

et al. 2019

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During calorie restriction (CR), endotherms adjust several physiological processes including the decrease of core body temperature (T b ) and reduction of energy expenditure. We recently found that CR-induced hypothermia is regulated in a sex-dependent manner in mice with lowered central insulin-like growth factor receptor signaling. Here, we describe the contribution of sex hormones to CR-induced hypothermia in wild type C57BL6 mice by measuring T b of female and male mice following bilateral gonadectomy and hormonal replacement. Specifically, we evaluated the effects of progesterone (P4), 17-ß estradiol (E2), a combination of both (P4 + E2) in females and of 5-α dihydrotestosterone (5-α DHT) in males. Gonadectomy resulted in an earlier and stronger CR-induced hypothermia in both sexes. These effects were fully antagonized in females by E2 replacement, but not by P4, which had only minor and partial effects when used alone and did not prevent the action of E2 during CR when both hormones were given in combination. 5-α-DHT had only minor and transient effects on preventing the reduction of T b during CR on gonadectomized male mice. These findings indicate that gonadal hormones contribute to sex-specific regulation of T b and energy expenditure when nutrient availability is scarce.

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Section: Introductionmentioning

confidence: 99%

Gonadal hormones influence core body temperature during calorie restriction

et al. 2019

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“…However, data on mice are highly inconsistent which might be due, for example, to different amount of handling stress when animals are restrained for temperature assessment. Nevertheless, a study using sensors inserted under the loose skin of the pelt of mice was able to show a drop in body temperature with aging [79].…”

Section: Discussionmentioning

confidence: 99%

Impact of the Age of Cecal Material Transfer Donors on Alzheimer’s Disease Pathology in 5xFAD Mice

Valeri

Guilherme

et al. 2021

Microorganisms

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Alzheimer’s disease is a progressive neurodegenerative disorder affecting around 30 million patients worldwide. The predominant sporadic variant remains enigmatic as the underlying cause has still not been identified. Since efficient therapeutic treatments are still lacking, the microbiome and its manipulation have been considered as a new, innovative approach. 5xFAD Alzheimer’s disease model mice were subjected to one-time fecal material transfer after antibiotics-treatment using two types of inoculation: material derived from the caecum of age-matched (young) wild type mice or from middle aged, 1 year old (old) wild type mice. Mice were profiled after transfer for physiological parameters, microbiome, behavioral tasks, and amyloid deposition. A single time transfer of cecal material from the older donor group established an aged phenotype in the recipient animals as indicated by elevated cultivatable fecal Enterobacteriaceae and Lactobacillaceae representative bacteria, a decreased Firmicutes amount as assessed by qPCR, and by increased levels of serum LPS binding protein. While behavioral deficits were not accelerated, single brain regions (prefrontal cortex and dentate gyrus) showed higher plaque load after transfer of material from older animals. We could demonstrate that the age of the donor of cecal material might affect early pathological hallmarks of Alzheimer’s disease. This could be relevant when considering new microbiome-based therapies for this devastating disorder.

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“…Elderly people have altered responses to changes in body temperature and are unable to regulate their body temperatures as efficiently as young adults (Güneş and Zaybak, 2008). Several studies reported that body temperature generally decrease in older people (DeGroot and Kenney, 2007;Güneş and Zaybak, 2008;Lu et al, 2009), and a similar pattern has also been shown in various animal models, such as laboratory mice and rats (Balmagiya and Rozovski, 1983;Talan and Engel, 1986;Scarpace et al, 1994;Gonzales and Rikke, 2010). The decreased body temperature in aged individuals can at least be partly due to the age-related decline of the basal metabolic rate (BMR) (review in De Magalhães et al, 2007;Moe et al, 2009) and a decreased thermogenic capacity (Lin et al, 2015).…”

Section: Introductionmentioning

confidence: 94%