Thermoregulation is not impaired in breast cancer survivors during moderate‐intensity exercise performed in warm and hot environments

Relf, Rebecca; Lee, Benjamin; Eichhorn, Gregor; Flint, Melanie S.; Beale, Louisa; Maxwell, Neil

doi:10.14814/phy2.14968

Cited by 2 publications

(2 citation statements)

References 79 publications

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“…The narrowing of the thermoneutral zone occurs secondary to abrupt decreases in oestrogen levels (e.g., use of oestrogen antagonists, menopause) that may result from long-term use of chemotherapy drugs, such as tamoxifen, that lead to early menopause onset (Moon et al, 2017). A recent study measured the level of thermal strain and inflammatory blood markers to exertional heat stress at 4 metabolic equivalents (METS) for 30 minutes in warm (25°C, 50% RH) or hot (35°C, 50% RH) conditions in breast cancer survivors (BCS) (Relf et al, 2021). The BCS did not exhibit any differences in whole body sweat rates, heart rate, skin temperature, and rectal temperature compared to control subjects.…”

Section: Cancer and Heat Stressmentioning

confidence: 99%

“…There is no clear mechanism to explain this functional decline despite similar thermoregulatory capacity between groups after heat exposure. However, previous chemotherapy use may be implicated in impaired cardiovascular function (Curigliano et al, 2010;Relf et al, 2021). Indeed, further investigations are warranted, considering that chemotherapy use is associated with autonomic nervous system decline, possibly contributing to pathogenesis of CVDs (Adams et al, 2015).…”

Section: Cancer and Heat Stressmentioning

confidence: 99%

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Effects of Medications on Heat Loss Capacity in Chronic Disease Patients: Health Implications Amidst Global Warming

et al. 2023

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Pharmacological agents used to treat or manage diseases can modify the level of heat strain experienced by chronically ill and elderly patients via different mechanistic pathways. Human thermoregulation is a crucial homeostatic process that maintains body temperature within a narrow range during heat stress through dry (i.e., increasing skin blood flow) and evaporative (i.e., sweating) heat loss, as well as active inhibition of thermogenesis, which is crucial to avoid overheating.Medications can independently and synergistically interact with ageing and chronic disease to alter homeostatic responses to rising body temperature during heat stress. This review focuses on the physiological changes, with specific emphasis on thermolytic processes, associated with medication use during heat stress. The review begins by providing readers with a background of the global chronic disease burden. Human thermoregulation and ageing effects are then summarised to give an understanding of the unique physiological changes faced by older adults. The effects of common chronic diseases on temperature regulation are outlined in the main sections. Physiological impacts of common medications used to treat these diseases are reviewed in detail, with emphasis on the mechanisms by which these medications alter thermolysis during heat stress. The review concludes by providing perspectives on the need to understand the effects of medication use in hot environments, as well as a summary table of all clinical considerations and research needs of the medications included in this review.

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Section: Cancer and Heat Stressmentioning

confidence: 99%

Section: Cancer and Heat Stressmentioning

confidence: 99%

Effects of Medications on Heat Loss Capacity in Chronic Disease Patients: Health Implications Amidst Global Warming

et al. 2023

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Experimental research in environmentally induced hyperthermic older persons: A systematic quantitative literature review mapping the available evidence

et al. 2023

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The heat-related health burden is expected to persist and worsen in the coming years due to an aging global population and climate change. Defining the breadth and depth of our understanding of age-related changes in thermoregulation can identify underlying causes and strategies to protect vulnerable individuals from heat. We conducted the first systematic quantitative literature review to provide context to the historical experimental research of healthy older adults – compared to younger adults or unhealthy age matched cases – during exogenous heat strain, focusing on factors that influence thermoregulatory function (e.g. co-morbidities). We identified 4,455 articles, with 147 meeting eligibility criteria. Most studies were conducted in the US (39%), Canada (29%), or Japan (12%), with 71% of the 3,411 participants being male. About 71% of the studies compared younger and older adults, while 34% compared two groups of older adults with and without factors influencing thermoregulation. Key factors included age combined with another factor (23%), underlying biological mechanisms (18%), age independently (15%), influencing health conditions (15%), adaptation potential (12%), environmental conditions (9%), and therapeutic/pharmacological interventions (7%). Our results suggest that controlled experimental research should focus on the age-related changes in thermoregulation in the very old, females, those with overlooked chronic heat-sensitive health conditions (e.g. pulmonary, renal, mental disorders), the impact of multimorbidity, prolonged and cumulative effects of extreme heat, evidence-based policy of control measures (e.g. personal cooling strategies), pharmaceutical interactions, and interventions stimulating protective physiological adaptation. These controlled studies will inform the directions and use of limited resources in ecologically valid fieldwork studies.

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Thermoregulation is not impaired in breast cancer survivors during moderate‐intensity exercise performed in warm and hot environments

Abstract: This is an open access article under the terms of the Creat ive Commo ns Attri bution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 2 publications

References 79 publications

Effects of Medications on Heat Loss Capacity in Chronic Disease Patients: Health Implications Amidst Global Warming

Effects of Medications on Heat Loss Capacity in Chronic Disease Patients: Health Implications Amidst Global Warming

Experimental research in environmentally induced hyperthermic older persons: A systematic quantitative literature review mapping the available evidence

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