Thermoresponsive magnetoliposome encapsulating doxorubicin and high performance Ferumoxytol for effective tumor synergistic therapy in vitro

Chen, Bo; Zhang, Ruren; Wu, Hao; Li, Mingyue; Zhou, Gaoxin; Ji, Min

doi:10.1016/j.jddst.2020.101677

Cited by 8 publications

(10 citation statements)

References 29 publications

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“…[8b] Ferumoxytol exhibits easily magnetized superparamagnetic behavior at room temperature. Jon Dobson et al found that ferumoxytol remained magnetized even in the absence of applied magnetic fields at 5 and 300 K by measuring the hysteresis loop of ferumoxytol, and the magnetization values of ferumoxytol were slightly larger than those for ferumoxytol measured in fields above 2 T. [22] The magnetic properties of ferumoxytol and the easy functionalization of carboxymethyl on the surfacecoated PSC make ferumoxytol have other potential functions in biomedicine except for being as an MRI contrast agent, such as magnetic fluid hyperthermia, [23] magneto-endosomalytic therapy (MELT), [24] magnetic induced drug delivery, [25] tissue magnetocaloric rewarming [26] and magnetic brain stimulation to improve depression, [27] etc.…”

Section: Physicochemical Propertiesmentioning

confidence: 99%

The Story of Ferumoxytol: Synthesis Production, Current Clinical Applications, and Therapeutic Potential

Long,

Li,

et al. 2023

Adv Healthcare Materials

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Ferumoxytol, approved by the U.S. Food and Drug Administration in 2009, is one of the intravenous iron oxide nanoparticles authorized for the treatment of iron deficiency in chronic kidney disease and end‐stage renal disease. With its exceptional magnetic properties, catalytic activity, and immune activity, as well as good biocompatibility and safety, ferumoxytol has gained significant recognition in various biomedical diagnoses and treatments. Unlike most existing reviews on this topic, this review primarily focuses on the recent clinical and preclinical advances of ferumoxytol in disease treatment, spanning anemia, cancer, infectious inflammatory diseases, regenerative medicine application, magnetic stimulation for neural modulation, etc. Additionally, the newly discovered mechanisms associated with the biological effects of ferumoxytol are discussed, including its magnetic, catalytic, and immunomodulatory properties. Finally, the summary and future prospects concerning the treatment and application of ferumoxytol‐based nanotherapeutics are presented.

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Section: Physicochemical Propertiesmentioning

confidence: 99%

The Story of Ferumoxytol: Synthesis Production, Current Clinical Applications, and Therapeutic Potential

Long,

Li,

et al. 2023

Adv Healthcare Materials

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“…A neoadjuvant chemo-treatment protocol using DOX synchronized with mild loco-regional MHT displayed remarkable improvements in survival rate of soft tissue sarcoma patients, due to cellular modification induced by MHT, e.g., DNA repair [ 237 ]. In this regard, a number of studies employed DOX and MHT in combination therapy ( Table 7 ) [ 137 , 238 , 239 , 240 ]. The decoration of carboxylate-functionalized PNIPAAm nano-gel (NG) with Fe 3 O 4 NPs via covalent bonds generated multi-modal diagnostic imaging and a thermal therapy tool which actuated DOX release due to the affinity of Fe to the carboxylate group [ 137 ].…”

Section: Stimuli-triggered Smnpsmentioning

confidence: 99%

“…Any temperature lower than LCST will be closer to body temperature (37 °C), leading to unexpected and early agent release, likewise, above LCST can affect healthy cells and cause adverse effects [ 137 , 158 , 241 ]. In vitro studies revealed the encapsulation of DOX by magneto-liposome (thermo-responsive agent) conjugated with ferumoxytol used in MHT and drug delivery could be a powerful modality for in vivo carcinoma treatment [ 238 ]. Additionally, Pourjavadi et al [ 242 ] used N-isopropylacrylamide (NIPAM) for the TR release of paclitaxel.…”

Section: Stimuli-triggered Smnpsmentioning

confidence: 99%

Smart and Multi-Functional Magnetic Nanoparticles for Cancer Treatment Applications: Clinical Challenges and Future Prospects

et al. 2022

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Iron oxide nanoparticle (IONPs) have become a subject of interest in various biomedical fields due to their magnetism and biocompatibility. They can be utilized as heat mediators in magnetic hyperthermia (MHT) or as contrast media in magnetic resonance imaging (MRI), and ultrasound (US). In addition, their high drug-loading capacity enabled them to be therapeutic agent transporters for malignancy treatment. Hence, smartening them allows for an intelligent controlled drug release (CDR) and targeted drug delivery (TDD). Smart magnetic nanoparticles (SMNPs) can overcome the impediments faced by classical chemo-treatment strategies, since they can be navigated and release drug via external or internal stimuli. Recently, they have been synchronized with other modalities, e.g., MRI, MHT, US, and for dual/multimodal theranostic applications in a single platform. Herein, we provide an overview of the attributes of MNPs for cancer theranostic application, fabrication procedures, surface coatings, targeting approaches, and recent advancement of SMNPs. Even though MNPs feature numerous privileges over chemotherapy agents, obstacles remain in clinical usage. This review in particular covers the clinical predicaments faced by SMNPs and future research scopes in the field of SMNPs for cancer theranostics.

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“…The authors also demonstrated in vitro that the combined therapy was more effective against breast cancer cells (MGSO-3) than the separate use of chemotherapy and hyperthermia. The synergy between chemotherapy and hyperthermia has been assessed in other systems comprising different payloads, including doxorubicin [42], curcumin [43], methotrexate [44], and cisplatin [36].…”

Section: Thermotherapeutic Strategies Using Magnetoliposomesmentioning

confidence: 99%

Magnetoliposomes: recent advances in the field of controlled drug delivery

Veloso

Andrade

Castanheira

2021

Expert Opinion on Drug Delivery

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Magnetoliposomes have gained increasing attention as delivery systems, as they surpass many limitations associated with liposomes. The combination with magnetic nanoparticles provides a means for development of multimodal and multifunctional theranostic agents that enable on-demand drug release and real-time monitoring of therapy.Areas covered: Recently, several magnetoliposome structures have been reported to ensure efficient transport and delivery of therapeutics, while improving magnetic properties. Besides, novel techniques have been introduced to improve on-demand release, as well as to achieve sequential release of different therapeutic agents. This review presents the major types and methods of preparation of magnetoliposomes, and discusses recent strategies in the trigger of drug release, development of theranostic formulations, and delivery of drugs and biological entities.Expert opinion: Despite significant advances in efficient drug delivery, current literature lacks an assessment of formulations as theranostic agents and complementary techniques to optimize thermotherapy efficiency. Plasmonic magnetoliposomes are highly promising multimodal and multifunctional systems, providing the required design versatility to optimize theranostic capabilities. Further, photodynamic therapy and delivery of proteins/genes can be improved with a deeper research on the employed magnetic material and associated toxicity.A scale-up procedure is also lacking in recent research, which is limiting their translation to clinical use.

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Thermoresponsive magnetoliposome encapsulating doxorubicin and high performance Ferumoxytol for effective tumor synergistic therapy in vitro

Cited by 8 publications

References 29 publications

The Story of Ferumoxytol: Synthesis Production, Current Clinical Applications, and Therapeutic Potential

The Story of Ferumoxytol: Synthesis Production, Current Clinical Applications, and Therapeutic Potential

Smart and Multi-Functional Magnetic Nanoparticles for Cancer Treatment Applications: Clinical Challenges and Future Prospects

Magnetoliposomes: recent advances in the field of controlled drug delivery

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