Thermoresponsive microgel decorated with silica nanoparticles in shell: Biomimetic synthesis and drug release application

Chai, Shugen; Zhang, Jinzhi; Yang, Tingting; Yuan, Jianjun; Chen, Shiyuan

doi:10.1016/j.colsurfa.2009.12.026

Cited by 40 publications

(28 citation statements)

References 50 publications

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“…We are interested in using polymeric particles with controlled structures and compositions as colloidal templates for biomimetic silica deposition [36][37][38]. Different to conventional polyamines for biomimetic silica deposition , our polymeric colloidal particles could be readily synthesized on a large scale, with the reasonable control over the particles diameter and polydispersity.…”

Section: Resultsmentioning

confidence: 99%

Microgel–silica hybrid particles: Strategies for tunable nanostructure, composition, surface property and porphyrin functionalization

Yuan

Liu

et al. 2010

Journal of Colloid and Interface Science

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Section: Resultsmentioning

confidence: 99%

Microgel–silica hybrid particles: Strategies for tunable nanostructure, composition, surface property and porphyrin functionalization

Yuan

Liu

et al. 2010

Journal of Colloid and Interface Science

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“…The loading of CyA into microgels was achieved by the incubation method. 31 First, 2 mg/mL of blank microgels solution was prepared as described above, followed by the addition of a methanol solution of CyA (1.0 wt%) dropwise into the blank microgels solution with stirring. The mixture was then incubated at 4°C for 24, 48, and 72 h. CyA-loaded HA-g-PNIPAAm (CyA-HAPN) microgels were isolated by centrifugation at 15,000 rpm for 15 min.…”

Section: Preparation Of Drug-free and Cya-loaded Ha-g-pnipaam Microgelsmentioning

confidence: 99%

Enhanced and sustained topical ocular delivery of cyclosporine A in thermosensitive hyaluronic acid-based in situ forming microgels

Wu¹,

Yao²,

Zhou³

et al. 2013

IJN

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“…Emulsion polymerization techniques have made great progress in the controlled synthesis of particles with tunable composition, morphology and size [33]. Over the past decade, great strides have been made in the fields of controlled and targeted drug delivery.…”

Section: Introductionmentioning

confidence: 99%

In Vitro Degradation and Drug-Release Properties of Water-Soluble Chitosan Cross-Linked Oxidized Sodium Alginate Core–Shell Microgels

Chen

Liu

Lii

et al. 2012

Journal of Biomaterials Science, Polymer Edition

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Hydrogels based on sodium alginate (SA) have already been widely used in biomedical applications using Ca(2+) as a cross-linker; however, these hydrogels tend to disintegrate in electrolyte solutions. To solve this problem, we present a kind of oxidized sodium alginate (OSA) microgel using water-soluble chitosan (WSC) as a cross-linker. This microgel was successfully prepared via an emulsion cross-linking technique at room temperature. The microgel was cross-linked by the formation of both Schiff base bonds and inter-polyelectrolyte complexes, which can efficiently eliminate the disintegration of the microgel in electrolyte solutions. Morphological properties of the resulting microgels were determined by transmission electron microscopy (TEM), hydrodynamic diameters of the microgels were characterized by dynamic light scattering (DLS). The objective of this work was to achieve the colon-specific delivery of an anti-ulcerative colitis drug. 5-Aminosalicylic acid (5-ASA) was chosen as a model drug and the in vitro drug-release profile was established in buffer solutions with 0.1 M HCl/NaCl (pH 1.2) and 0.1 M phosphate-buffered saline (PBS, pH 7.4) at 37°C. The microgel was incubated in 0.1 M PBS (pH 7.4) at 37°C to determine its degradation behavior. Cell cytotoxicity (tested by MTT assay) showed that this microgel had no significant cytotoxicity. These results indicated that this microgel prepared by introducing WSC into OSA may have potential applications in oral controlled drug-delivery systems. Therefore, the OSA/WSC microgel may be a useful carrier for the colon-specific delivery of anti-inflammatory drugs including 5-ASA and the enhanced therapeutic effect of ulcerative colitis.

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Thermoresponsive microgel decorated with silica nanoparticles in shell: Biomimetic synthesis and drug release application

Cited by 40 publications

References 50 publications

Microgel–silica hybrid particles: Strategies for tunable nanostructure, composition, surface property and porphyrin functionalization

Microgel–silica hybrid particles: Strategies for tunable nanostructure, composition, surface property and porphyrin functionalization

Enhanced and sustained topical ocular delivery of cyclosporine A in thermosensitive hyaluronic acid-based in situ forming microgels

In Vitro Degradation and Drug-Release Properties of Water-Soluble Chitosan Cross-Linked Oxidized Sodium Alginate Core–Shell Microgels

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