Thermosensitive chitosan/phosphate hydrogel-composites fortified with Ag versus Ag@Pd for biomedical applications

Ali, Ghareib W.; Hotaby, Walid El; Hemdan, Bahaa A.; Abdel-Fattah, Wafa I.

doi:10.1016/j.lfs.2017.12.021

Cited by 47 publications

(21 citation statements)

References 25 publications

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“…This set of materials proved osteogenic ability, displayed antibacterial activity and lack of toxicity. Hence, they are promising for dental surgery purposes [118].…”

Section: Thermosensitive Gelsmentioning

confidence: 99%

Concepts for Developing Physical Gels of Chitosan and of Chitosan Derivatives

Sacco

Furlani

Marzo

et al. 2018

Gels

110

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Chitosan macro- and micro/nano-gels have gained increasing attention in recent years, especially in the biomedical field, given the well-documented low toxicity, degradability, and non-immunogenicity of this unique biopolymer. In this review we aim at recapitulating the recent gelling concepts for developing chitosan-based physical gels. Specifically, we describe how nowadays it is relatively simple to prepare networks endowed with different sizes and shapes simply by exploiting physical interactions, namely (i) hydrophobic effects and hydrogen bonds—mostly governed by chitosan chemical composition—and (ii) electrostatic interactions, mainly ensured by physical/chemical chitosan features, such as the degree of acetylation and molecular weight, and external parameters, such as pH and ionic strength. Particular emphasis is dedicated to potential applications of this set of materials, especially in tissue engineering and drug delivery sectors. Lastly, we report on chitosan derivatives and their ability to form gels. Additionally, we discuss the recent findings on a lactose-modified chitosan named Chitlac, which has proved to form attractive gels both at the macro- and at the nano-scale.

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“…This set of materials proved osteogenic ability, displayed antibacterial activity and lack of toxicity. Hence, they are promising for dental surgery purposes [118].…”

Section: Thermosensitive Gelsmentioning

confidence: 99%

Concepts for Developing Physical Gels of Chitosan and of Chitosan Derivatives

Sacco

Furlani

Marzo

et al. 2018

Gels

110

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“…Additionally, it is readily available at low cost [15]. Recently, several manuscripts were reported for the synthesis of gold (Au), silver (Ag), and palladium (Pd) nanoparticles using plant extracts as Geranium leaf [16], Aloe vera [17], Lemongrass [18], and BlackBerry [19].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of nontoxic silver nano-particles with preferential bactericidal activity

2019

Biointerface Res Appl Chem

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The massive prophylactically or remedially application of antibiotics without proper medical indications lead to severe problems of bacterial resistance. Nanoparticles (NPs) are increasingly applied to target bacterial infections as an antibiotic alternative. Green synthesis of silver nanoparticles (AgNPs), with controlled morphology, within cinnamon extract using microwave irradiation was carried out. The influence of the pH on the synthesized AgNPs was assessed. Physicochemical characterizations were followed through UV, FTIR, FESEM, HRTEM, XPS and XRD analyses. Bactericidal activity and in-vitro cytotoxicity of the achieved AgNPs were investigated. Results proved the successful synthesis of spherical AgNPs with an average size of 15 nm. The AgNPs safety was verified through cytotoxicity test against skin fibroblast normal cells. The obtained AgNPs exhibited promising bactericidal activities against the screening of several Gram+ve and Gram-ve bacteria. Therefore, it can be successfully applied in the biomedical fields for hard and soft tissue remedies.

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“…The results further proved that the reduction rate of silver is less than 100%. Ag 2 O is also an antibacterial agent [25], which could increase the antibacterial performance of the product.…”

Section: Resultsmentioning

confidence: 99%

Antibacterial Superabsorbent Polymers from Tara Gum Grafted Poly(Acrylic acid) Embedded Silver Particles

et al. 2018

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Tara gum/silver composite superabsorbent polymers were synthesized with tara gum grafted poly(acrylic acid), using K 2 S 2 O 8 (KPS) as an initiator and N,N -methylenebisacrylamide (MBA) as a cross-linker. The products were characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), transmission electron microscope (TEM), scanning electron microscope (SEM) and X-ray photoelectron spectroscopy (XPS). The results showed that the silver ions were partially reduced to Ag 0 and the amorphous nanoparticles containing Ag 0 and Ag 2 O were around 10~50 nm in size The tara gum/silver composite superabsorbent polymers exhibited an interconnected porous structure with strong water absorption capacity. The swelling ratio of each product could reach 473 g/g in distilled water and 62 g/g in 0.9% NaCl solution. The antimicrobial activity of the samples against Staphylococcus aureus and Escherichia coli increased with the addition of AgNO 3 from 0 to 125 mg. This work indicates that the developed tara gum/silver composite superabsorbent polymers can be potentially used for biomedical applications.

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Thermosensitive chitosan/phosphate hydrogel-composites fortified with Ag versus Ag@Pd for biomedical applications

Cited by 47 publications

References 25 publications

Concepts for Developing Physical Gels of Chitosan and of Chitosan Derivatives

Concepts for Developing Physical Gels of Chitosan and of Chitosan Derivatives

Synthesis and characterization of nontoxic silver nano-particles with preferential bactericidal activity

Antibacterial Superabsorbent Polymers from Tara Gum Grafted Poly(Acrylic acid) Embedded Silver Particles

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