Thermosensitive hydrogels for sustained-release of sorafenib and selenium nanoparticles for localized synergistic chemoradiotherapy

Zheng, Lan; Li, Chang'e; Huang, Xiaoting; Lin, Xueran; Lin, Weiqiang; Yang, Fang; Chen, Tianfeng

doi:10.1016/j.biomaterials.2019.05.031

Cited by 100 publications

(51 citation statements)

References 52 publications

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“…6b), demonstrating the safety of the RS in radiotherapy. 38 Based on the experimental results, we concluded that the specic accumulation of Ir-NB in tumor sites by drug delivery improves bioavailability and alleviate undesirable side effects of radiotherapy.…”

Section: In Vivo Radiosensitization Effect Of the Ir-nb Prodrugmentioning

confidence: 91%

A highly X-ray sensitive iridium prodrug for visualized tumor radiochemotherapy

Zhao

Gao

et al. 2020

Chem. Sci.

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Section: In Vivo Radiosensitization Effect Of the Ir-nb Prodrugmentioning

confidence: 91%

A highly X-ray sensitive iridium prodrug for visualized tumor radiochemotherapy

Zhao

Gao

et al. 2020

Chem. Sci.

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“…Compared with untreated patients, sorafenib prolonged the overall survival of HCC patients by only 2.8 months [26,27]. Because of its side effects of drug resistance, there is a lack of clinical efficacy [28]. Therefore, it is of considerable significance to explore the resistance of sorafenib in the treatment of hepatocellular carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive Network Analysis of the Molecular Mechanisms Associated with Sorafenib Resistance in Hepatocellular Carcinoma

Cui

Wei

et al. 2019

Preprint

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Background: This research aimed to investigate the potential molecular mechanism of sorafenib resistance to hepatocellular carcinoma (HCC). Methods: Differential expression analysis were performed to identified differentially expressed genes (DEGs) in sorafenib resistant HCC. Then, a series of bioinformatic analysis were performed to explore the potential crucial molecules in sorafenib resistant HCC. For example, gene function annotation, pivot regulators prediction, ROC analysis and survival analysis. Results: There were 827 differentially expressed genes were identified. Moreover, most of the differentially expressed genes are involved in immune and inflammatory-related functions and signaling pathways. Also, 18 transcription factors were predicted to regulate the transcription factors of differentially expressed genes, which play an essential role in the regulation of dysfunctional gene networks. In target genes of transcription factors, CDK1 and CDKN1A have high diagnostic value in the resistance of hepatocellular carcinoma to sorafenib. Conclusions: TAPBP has the strongest correlation with drug resistance of hepatocellular carcinoma and the highest diagnostic efficiency. In addition, CDK1 and CDKN1A have high diagnostic value in the resistance of hepatocellular carcinoma to sorafenib. Overall, our analysis shows that a large number of gene disorders occur during the development of resistance to sorafenib in hepatocellular carcinoma, and they are associated with immune and inflammatory reactions in the body. These results provide critical theoretical references for the pathogenesis and diagnosis of sorafenib resistance.

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“…We combined our decade‐long nanotechnology and TB immunology expertise to innovate the macrophage‐targeted selenium nanomaterials for synergistic antimicrobial and bactericidal destruction of Mtb in host cells. Virtually, selenium nanomaterials can function as anticancer agents, inhibit E. coli , S . aureus, and S .…”

Section: Methodsmentioning

confidence: 99%

Macrophage‐Targeted Isoniazid–Selenium Nanoparticles Promote Antimicrobial Immunity and Synergize Bactericidal Destruction of Tuberculosis Bacilli

Shen

Yang

et al. 2020

Angew Chem Int Ed

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Pathogenesis hallmarks for tuberculosis (TB) are the Mycobacterium tuberculosis (Mtb) escape from phagolysosomal destruction and limited drug delivery into infected cells. Several nanomaterials can be entrapped in lysosomes, but the development of functional nanomaterials to promote phagolysosomal Mtb clearance remains a big challenge. Here, we report on the bactericidal effects of selenium nanoparticles (Se NPs) against Mtb and further introduce a novel nanomaterial‐assisted anti‐TB strategy manipulating Ison@Man‐Se NPs for synergistic drug‐induced and phagolysosomal destruction of Mtb. Ison@Man‐Se NPs preferentially entered macrophages and accumulated in lysosomes releasing Isoniazid. Surprisingly, Ison@Man‐Se/Man‐Se NPs further promoted the fusion of Mtb into lysosomes for synergistic lysosomal and Isoniazid destruction of Mtb. Concurrently, Ison@Man‐Se/Man‐Se NPs also induced autophagy sequestration of Mtb, evolving into lysosome‐associated autophagosomal Mtb degradation linked to ROS‐mitochondrial and PI3K/Akt/mTOR signaling pathways. This novel nanomaterial‐assisted anti‐TB strategy manipulating antimicrobial immunity and Mtb clearance may potentially serve in more effective therapeutics against TB and drug‐resistant TB.

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Thermosensitive hydrogels for sustained-release of sorafenib and selenium nanoparticles for localized synergistic chemoradiotherapy

Cited by 100 publications

References 52 publications

A highly X-ray sensitive iridium prodrug for visualized tumor radiochemotherapy

A highly X-ray sensitive iridium prodrug for visualized tumor radiochemotherapy

Comprehensive Network Analysis of the Molecular Mechanisms Associated with Sorafenib Resistance in Hepatocellular Carcinoma

Macrophage‐Targeted Isoniazid–Selenium Nanoparticles Promote Antimicrobial Immunity and Synergize Bactericidal Destruction of Tuberculosis Bacilli

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