Thermosensitive P(NIPAM-co-AM)-b-PLA block copolymer micelles for applications in intracellular drug delivery

Xu, Feng; Zhang, Bi-Xia; Luo, Yan‐Ling

doi:10.1016/s1773-2247(14)50022-6

Cited by 13 publications

(4 citation statements)

References 24 publications

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“…[22][23][24] Hence, as a tumor cell-specific targeted macromolecule, HA could also be used as a capping agent to control the drug release in response to HAase present in the intracellular environment. [25][26][27] As aforementioned, AuNCs, HA and the copolymer PM are appropriate materials to construct a novel drug delivery system.…”

Section: Introductionmentioning

confidence: 99%

Construction and application of a liver cancer-targeting drug delivery system based on core–shell gold nanocages

Ji¹,

Qiu²,

Hou³

et al. 2018

IJN

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BackgroundIn order to achieve drug targeting and controlled release, we have successfully developed a novel drug release system DOX/AuNCs-PM-HA with gold nanocages (AuNCs) as photothermal cores, thermally responsive copolymer P(NIPAM-co-Am) (PM) as the near-infrared (NIR) stimuli gatekeeper and hyaluronic acid as a targeting ligand as well as a capping agent.MethodsCell uptake and cell viability were investigated. In vivo photoacoustic tomography imaging in H22 tumor bearing mice was analyzed for the tumor targeting effect of the nanocomplexes. Antitumor efficacy and the tissue distribution in vivo were investigated.ResultsIn vitro results demonstrated that the DOX/AuNCs-PM-HA had significant anticancer activity against SMMC-7721 cells under NIR irradiation. Furthermore, in vivo photoacoustic tomography imaging of the nanocomplexes in H22 tumor bearing mice could indicate effective tumor targeting. Our studies on antitumor efficacy and the tissue distribution in vivo showed that many DOX/AuNCs-PM-HA nanocomplexes could efficiently accumulate at the tumor site so that they could inhibit the tumor growth effectively with limited side effects. The in vitro and in vivo results confirmed that the tumor-targeting and controlled-release drug system DOX/AuNCs-PM-HA with the combination of chemotherapy and photothermal therapy showed strong anti-tumor effect and would have great potential for future cancer therapy.ConclusionThis tumor targeting DOX/AuNCs-PM-HA nanocomplex responded not only to the external stimuli of NIR, but also the internal stimuli of hyaluronidase, providing the potential for pinpointed and multi-stimuli responsive intracellular drug release.

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Section: Introductionmentioning

confidence: 99%

Construction and application of a liver cancer-targeting drug delivery system based on core–shell gold nanocages

Ji¹,

Qiu²,

Hou³

et al. 2018

IJN

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“…PTX loaded micelles were quite efficient as compared to two other drug loaded micelles regarding higher drug loading capacity, entrapment efficiency and thermoresponsive behaviour towards release of drug. 177 Another acrylamide based polymer, poly(acrylamide-co-acetonitrile)-g-polyethyleneglycol ( poly(AAm-co-AN)-g-PEG) developed by Li et al had a UCST of 43 °C and was capable of undergoing self-assembly to form micelles in aqueous solutions at ambient temperature. Almost 80% of the encapsulated DOX was released from micelles at 43 °C but at body temperature, release was slow with minimal release.…”

Section: Temperature Responsive Polymeric Nanoparticlesmentioning

confidence: 99%

Trigger responsive polymeric nanocarriers for cancer therapy

et al. 2015

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Conventional chemotherapy for the treatment of cancer has limited specificity when administered systemically and is often associated with toxicity issues. Enhanced accumulation of polymeric nanocarriers at a tumor site may be achieved by passive and active targeting. Incorporation of trigger responsiveness into these polymeric nanocarriers improves the anticancer efficacy of such systems by modulating the release of the drug according to the tumor environment. Triggers used for tumor targeting include internal triggers such as pH, redox and enzymes and external triggers such as temperature, magnetic field, ultrasound and light. While internal triggers are specific cues of the tumor microenvironment, external triggers are those which are applied externally to control the release. This review highlights the various strategies employed for the preparation of such trigger responsive polymeric nanocarriers for cancer therapy and provides an overview of the state of the art in this field.

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“…[27][28][29] In the last few decades, many researchers have developed pNIPAM based thermo-sensitive copolymers for drug release study. [5,6,[30][31][32][33][34][35][36] However, to the best of our knowledge, this is the first time where TKP and pNIPAM based graft copolymer have been synthesized through control radical polymerization technique and used as host molecule to study the encapsulation and release behavior of Nile red dye. Previously, many researcher used Nile red as host molecule for encapsulation and release study because it is inexpensive and easy to handle.…”

Section: Introductionmentioning

confidence: 99%

“…It also provides control over the molecular weight, polydispersity index (PDI) and composition [27–29] . In the last few decades, many researchers have developed pNIPAM based thermo‐sensitive copolymers for drug release study [5,6,30–36] . However, to the best of our knowledge, this is the first time where TKP and pNIPAM based graft copolymer have been synthesized through control radical polymerization technique and used as host molecule to study the encapsulation and release behavior of Nile red dye.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Tamarind Gum and Poly (N‐isopropyl acrylamide)‐based Copolymer through Atom Transfer Radical Polymerization for Dual‐responsive Release Study

Karmakar,

Pal

2023

ChemistrySelect

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Over the past decades, thermoresponsive polymers are attracted much scientific attention and can be widely used in a wide range of applications. Synthesis of polymers throughCfunctionalization of polysaccharide using synthetic materials paves the way for producing much desirable natural biopolymer‐based copolymers. Therefore, this study reported about synthesis of thermo and pH‐responsive polymers, based on tamarind kernel polysaccharide (TKP) and poly (N‐isopropyl acrylamide) (pNIPAM) through atom transfer radical polymerization (ATRP) with controlled polymer chain length. The chemical structure and surface morphology have been investigated by different characterization techniques. Lower Critical Solution Temperature (LCST) confirmed the thermo‐responsive nature of the copolymer. The self‐aggregation among the polymer chains was found above LCST (34 °C). Rheological characterizations suggested that our prepared copolymers are non‐Newtonian shear thinning in nature. Finally, the developed material shows worthy efficacy towards the thermo‐responsive release of encapsulated dye at pH 7.4 (53 % and 65 % at 37 °C and 25 °C, respectively) suggesting that our prepared material could be a good candidate for therapeutic release in tissue engineering application.

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Thermosensitive P(NIPAM-co-AM)-b-PLA block copolymer micelles for applications in intracellular drug delivery

Cited by 13 publications

References 24 publications

Construction and application of a liver cancer-targeting drug delivery system based on core–shell gold nanocages

Construction and application of a liver cancer-targeting drug delivery system based on core–shell gold nanocages

Trigger responsive polymeric nanocarriers for cancer therapy

Synthesis of Tamarind Gum and Poly (N‐isopropyl acrylamide)‐based Copolymer through Atom Transfer Radical Polymerization for Dual‐responsive Release Study

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Thermosensitive P(NIPAM-co-AM)-b-PLA block copolymer micelles for applications in intracellular drug delivery

Cited by 13 publications

References 24 publications

Construction and application of a liver cancer-targeting drug delivery system based on core&ndash;shell gold nanocages

Construction and application of a liver cancer-targeting drug delivery system based on core&ndash;shell gold nanocages

Trigger responsive polymeric nanocarriers for cancer therapy

Synthesis of Tamarind Gum and Poly (N‐isopropyl acrylamide)‐based Copolymer through Atom Transfer Radical Polymerization for Dual‐responsive Release Study

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Construction and application of a liver cancer-targeting drug delivery system based on core–shell gold nanocages

Construction and application of a liver cancer-targeting drug delivery system based on core–shell gold nanocages