Thermosensitive polymer-conjugated albumin nanospheres as thermal targeting anti-cancer drug carrier

Shen, Zheyu; Wei, Wei; Zhao, Yongjiang; Ma, Guanghui; Dobashi, Toshiaki; Maki, Yasuyuki; Su, Zhiguo; Wan, Jinpei

doi:10.1016/j.ejps.2008.07.006

Cited by 75 publications

(32 citation statements)

References 27 publications

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“…the release of drug can be accelerated by high amount of enzymes in the target tumor tissues [39,40]. In addition, the slow release with pH-dependent manner may possibly prolong the systemic circulation, lower the drug elimination in in vivo and increase the extracellular drug concentration at the tumor site [7].…”

Section: Tablementioning

confidence: 99%

Enhanced toxicity and cellular uptake of methotrexate-conjugated nanoparticles in folate receptor-positive cancer cells by decorating with folic acid-conjugated d -α-tocopheryl polyethylene glycol 1000 succinate

Junyaprasert

Dhanahiranpruk

Suksiriworapong

et al. 2015

Colloids and Surfaces B: Biointerfaces

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Section: Tablementioning

confidence: 99%

Enhanced toxicity and cellular uptake of methotrexate-conjugated nanoparticles in folate receptor-positive cancer cells by decorating with folic acid-conjugated d -α-tocopheryl polyethylene glycol 1000 succinate

Junyaprasert

Dhanahiranpruk

Suksiriworapong

et al. 2015

Colloids and Surfaces B: Biointerfaces

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“…[3] The procedure of the DPS test is based on a procedure that has been described previously. [23] Different standard solutions containing increasing cysteine concentrations (10,20,30,40, 80 mM) were prepared in 10 Â 10 À3 M phosphate buffer at pH 7.0. Each of these samples, the native protein HSA as well as (7) were incubated with a solution of constant amounts of DPS (360 Â 10 À6 M) in 10 Â 10 À3 M phosphate buffer at pH 7.0.…”

Section: Preparation Of (9) By Complex Formation With Pdimentioning

confidence: 99%

“…received major recognition in view of their capacity to deliver drug molecules such as doxorubicin, [6] camptothecin, [7] , methotrexate, [8] or others [9] as well as macromolecules such as thermosensitive polymers [10] or DNA [11][12][13] and low cytotoxicity together with high membrane uptake were reported in some cases. [11] The success of HSA as a carrier is mainly based on its biocompatibility as well as the improved pharmacokinetic properties of HSA-drug conjugates compared with single drug molecules.…”

Section: Introductionmentioning

confidence: 99%

Tailored Albumin‐based Copolymers for Receptor‐Mediated Delivery of Perylenediimide Guest Molecules

Eisele

Gropeanu

Musante

et al. 2010

Macromol. Rapid Commun.

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The synthesis of a novel and multifunctional copolymer based on a human serum albumin backbone bearing several folic acid as well as PEO groups was presented. In solution, this side-chain copolymer adopts a globular architecture and about five molecules of the water-insoluble chromophore PDI were successfully incorporated into these micelles for receptor-mediated cell uptake investigations. A significant uptake of these bioconjugates via receptor-mediated endocytosis was detected for cells expressing folic acid receptors in the cell membrane. These novel albumin-based copolymers could serve as efficient and biocompatible carrier systems facilitating the directed delivery of lipophilic drug molecules into cancer cells and they allow investigating vesicle formation and trafficking even at the single molecule level.

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“…So unterscheidet sich zum Beispiel entzündetes von gesundem Ge webe unter anderem durch einen nied rigeren pHWert, eine erhöhte Tempera tur oder eine erhöhte Gefäßpermeabilität [38]. Diese Eigenschaften kann man sich zum Beispiel beim "Targeting" mit Tem peratur und pHsensitiven Nanoparti keln zunutze machen [39,40].…”

Section: Aktuelle Entwicklungen Bei Nanopartikulären Wirkstoffträgernunclassified

Pharmakotherapie mittels Nanomedizin

Tietze

Schreiber

Lyer

2010

Bundesgesundheitsbl.

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The application of nanotechnology for the treatment, diagnosis, and monitoring of illnesses is summarized under the term nanomedicine. A particularly promising application is attributed to nanoparticular drug delivery systems. The goal of these new carrier systems is the selective enrichment of active substances in diseased tissue structures, an increase in bioavailability, the decrease of the active substance degradation and, above all, the reduction and/or avoidance of unwanted side effects. Apart from numerous nanosystems acting as carriers, the use of iron oxide nanoparticles has to be particularly emphasized. On the one hand, those particles are the carriers of the active substance and, on the other hand, can also be visualized with conventional imaging techniques (x-ray tomography, magnetic resonance imaging), called theranostic. In addition, they can be used for hyperthermia, another important supporting pillar of nanomedicine. Both procedures should lead to a personalized and goal-oriented therapy, which is of special medical and socioeconomic importance in view of the increasing number of cancer patients worldwide.

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Thermosensitive polymer-conjugated albumin nanospheres as thermal targeting anti-cancer drug carrier

Cited by 75 publications

References 27 publications

Enhanced toxicity and cellular uptake of methotrexate-conjugated nanoparticles in folate receptor-positive cancer cells by decorating with folic acid-conjugated d -α-tocopheryl polyethylene glycol 1000 succinate

Enhanced toxicity and cellular uptake of methotrexate-conjugated nanoparticles in folate receptor-positive cancer cells by decorating with folic acid-conjugated d -α-tocopheryl polyethylene glycol 1000 succinate

Tailored Albumin‐based Copolymers for Receptor‐Mediated Delivery of Perylenediimide Guest Molecules

Pharmakotherapie mittels Nanomedizin

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