Thermosensitive Polymers and Thermo-Responsive Liposomal Drug Delivery Systems

Abuwatfa, Waad H.; Awad, Nahid S.; Pitt, William G.; Husseini, Ghaleb A.

doi:10.3390/polym14050925

Cited by 66 publications

(28 citation statements)

References 106 publications

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“…In addition to taking advantage of falling below the necrosis threshold, the LTSL exhibited a promising in vivo result in prohibiting tumor growth (Needham et al, 2000). In another study, it has been reported that LTSL-containing DOX in combination with hyperthermia has a significant therapeutic FIGURE 5 (A) Configurations of a TTSL (up) and an LTSL (down) before, and (B) after the transition from gel to liquid phase (Abuwatfa et al, 2022). No permission is required.…”

Section: Thermo-responsive Liposomesmentioning

confidence: 99%

“… (A) Configurations of a TTSL (up) and an LTSL (down) before, and (B) after the transition from gel to liquid phase ( Abuwatfa et al, 2022 ). No permission is required.…”

Section: Liposomes For Delivery Of Therapeutic and Imaging Agentsmentioning

confidence: 99%

“…To overcome the shortage of high thermal doses by TTSLs, the concept of incorporating lysolipids or thermo-sensitive polymers into the liposomes was proposed. In this regard, the modified liposomes release the drug under mild hyperthermia (39–42°C) in a burst manner, allowing the liposomes to be more clinically applicable ( Abuwatfa et al, 2022 ).…”

Section: Liposomes For Delivery Of Therapeutic and Imaging Agentsmentioning

confidence: 99%

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Physically stimulus-responsive nanoparticles for therapy and diagnosis

et al. 2022

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Nanoparticles offer numerous advantages in various fields of science, particularly in medicine. Over recent years, the use of nanoparticles in disease diagnosis and treatments has increased dramatically by the development of stimuli-responsive nano-systems, which can respond to internal or external stimuli. In the last 10 years, many preclinical studies were performed on physically triggered nano-systems to develop and optimize stable, precise, and selective therapeutic or diagnostic agents. In this regard, the systems must meet the requirements of efficacy, toxicity, pharmacokinetics, and safety before clinical investigation. Several undesired aspects need to be addressed to successfully translate these physical stimuli-responsive nano-systems, as biomaterials, into clinical practice. These have to be commonly taken into account when developing physically triggered systems; thus, also applicable for nano-systems based on nanomaterials. This review focuses on physically triggered nano-systems (PTNSs), with diagnostic or therapeutic and theranostic applications. Several types of physically triggered nano-systems based on polymeric micelles and hydrogels, mesoporous silica, and magnets are reviewed and discussed in various aspects.

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Section: Thermo-responsive Liposomesmentioning

confidence: 99%

“… (A) Configurations of a TTSL (up) and an LTSL (down) before, and (B) after the transition from gel to liquid phase ( Abuwatfa et al, 2022 ). No permission is required.…”

Section: Liposomes For Delivery Of Therapeutic and Imaging Agentsmentioning

confidence: 99%

Section: Liposomes For Delivery Of Therapeutic and Imaging Agentsmentioning

confidence: 99%

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Physically stimulus-responsive nanoparticles for therapy and diagnosis

et al. 2022

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“…In particular, thermo-responsive polymers exhibiting a lower critical solution temperature (LCST) in aqueous medium are promising materials due to their outstanding performance temperature-induced drug delivery or tissue engineering [ 21 , 22 ]. Among thermo-responsive polymers, poly(ethylene glycol) (PEG) and its derivatives exhibit thermo-sensitive nature with tunable LCST as well as antifouling properties, protein resistance (i.e., minimal protein corona formation [ 23 ]), and excellent biocompatibility [ 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Mesoporous Silica and Oligo (Ethylene Glycol) Methacrylates-Based Dual-Responsive Hybrid Nanogels

et al. 2022

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Polymeric-inorganic hybrid nanomaterials have emerged as novel multifunctional platforms because they combine the intrinsic characteristics of both materials with unexpected properties that arise from synergistic effects. In this work, hybrid nanogels based on mesoporous silica nanoparticles, oligo (ethylene glycol) methacrylates, and acidic moieties were developed employing ultrasound-assisted free radical precipitation/dispersion polymerization. Chemical structure was characterized by infrared spectroscopy and nuclear magnetic resonance. Hydrodynamic diameters at different temperatures were determined by dynamic light scattering, and cloud point temperatures were determined by turbidimetry. Cell viability in fibroblast (NIH 3T3) and human prostate cancer (LNCaP) cell lines were studied by a standard colorimetric assay. The synthetic approach allows covalent bonding between the organic and inorganic components. The composition of the polymeric structure of hybrid nanogels was optimized to incorporate high percentages of acidic co-monomer, maintaining homogeneous nanosized distribution, achieving appropriate volume phase transition temperature values for biomedical applications, and remarkable pH response. The cytotoxicity assays show that cell viability was above 80% even at the highest nanogel concentration. Finally, we demonstrated the successful cell inhibition when they were treated with camptothecin-loaded hybrid nanogels.

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“…In the past few years, stimuli-responsive (temperature, pH, ionic strength, pressure) polymers have drawn considerable interest due to their potential for a wide range of applications. Such polymers can be used in biomedical applications such as on-demand drug delivery [ 1 , 2 , 3 , 4 , 5 , 6 , 7 ], diagnostics [ 4 ], bioadhesion [ 8 , 9 , 10 , 11 , 12 ] or tissue engineering [ 3 , 13 , 14 ] due to their thermally reversible coil-to-globule transition. Polymers with a thermoresponsive behavior may display either an upper (UCST) or a lower (LCST) critical solution temperature.…”

Section: Introductionmentioning

confidence: 99%

Unexpected Slow Kinetics of Poly(Methacrylic Acid) Phase Separation in the Semi-Dilute Regime

et al. 2022

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Poly (methacrylic acid) (PMAA) solutions are known to exhibit a lower critical solution temperature (LCST). A temperature-composition phase diagram of PMAA has been constructed by standard cloud point determination through transmittance measurements, and also by studying the steady states reached under phase separation. This allows us to reconstruct the binodal curve describing the phase behavior of PMAA for both low and high concentration regimes, and to determine accurately the LCST temperature. In a second step, the structures formed following a temperature jump above the cloud point and their evolution in time have been investigated at the nanoscale using small angle neutron scattering (SANS). This approach shows that the formation of phase-separated nanostructures is a slow process, requiring more than 12 h. The formed structures are then shown to depend on the amplitude of the temperature jump above the cloud point. An original mechanism of phase separation is identified in the semi-dilute regime. The growth of micrometric-size droplets with an inner structure displaying the rheological properties of a gel leads to the formation of a percolating network which hinders the influence of gravity. Such a result can explain the slow kinetics of the PMAA LCST transition.

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Thermosensitive Polymers and Thermo-Responsive Liposomal Drug Delivery Systems

Cited by 66 publications

References 106 publications

Physically stimulus-responsive nanoparticles for therapy and diagnosis

Physically stimulus-responsive nanoparticles for therapy and diagnosis

Mesoporous Silica and Oligo (Ethylene Glycol) Methacrylates-Based Dual-Responsive Hybrid Nanogels

Unexpected Slow Kinetics of Poly(Methacrylic Acid) Phase Separation in the Semi-Dilute Regime

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