Thermosensitive smart hydrogel of PEITC ameliorates the therapeutic efficacy in rheumatoid arthritis

Haloi, Prakash; Chawla, Saurabh; Konkimalla, V. Badireenath

doi:10.1016/j.ejps.2022.106367

Cited by 16 publications

(5 citation statements)

References 97 publications

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“…The injectable hydrogels can be crosslinked for gelation within the target site after injection [81] . Light can penetrate target sites like intra-articular joint cavities, and initiate the conversion of a liquid monomer or macromer by the cross-linking reaction to form a hydrogel through free radical polymerization, even under controlled ambient or physiological conditions [77] .…”

Section: Hydrogel For Ra Treatmentmentioning

confidence: 99%

Development of biomedical hydrogels for rheumatoid arthritis treatment

Baig,

Wong,

Zia

et al. 2024

Asian Journal of Pharmaceutical Sciences

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Section: Hydrogel For Ra Treatmentmentioning

confidence: 99%

Development of biomedical hydrogels for rheumatoid arthritis treatment

Baig,

Wong,

Zia

et al. 2024

Asian Journal of Pharmaceutical Sciences

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“…Local administration of this hydrogel significantly reduced inflammation markers in a rat model of arthritis, overcoming the limitations of phenethyl isothiocyanate, i.e., thermal instability and rapid clearance. Incorporating phenethyl isothiocyanate into the hydrogel allowed for prolonged therapeutic activity at sub-toxic levels, highlighting the potential of polysaccharide-based hydrogels as carriers for various phytochemicals with similar limitations [227].…”

Section: Drug Delivery In the Treatment Of Non-cancer Diseasesmentioning

confidence: 99%

Biomedical Trends in Stimuli-Responsive Hydrogels with Emphasis on Chitosan-Based Formulations

Kruczkowska,

Gałęziewska,

Grabowska

et al. 2024

Gels

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Biomedicine is constantly evolving to ensure a significant and positive impact on healthcare, which has resulted in innovative and distinct requisites such as hydrogels. Chitosan-based formulations stand out for their versatile utilization in drug encapsulation, transport, and controlled release, which is complemented by their biocompatibility, biodegradability, and non-immunogenic nature. Stimuli-responsive hydrogels, also known as smart hydrogels, have strictly regulated release patterns since they respond and adapt based on various external stimuli. Moreover, they can imitate the intrinsic tissues’ mechanical, biological, and physicochemical properties. These characteristics allow stimuli-responsive hydrogels to provide cutting-edge, effective, and safe treatment. Constant progress in the field necessitates an up-to-date summary of current trends and breakthroughs in the biomedical application of stimuli-responsive chitosan-based hydrogels, which was the aim of this review. General data about hydrogels sensitive to ions, pH, redox potential, light, electric field, temperature, and magnetic field are recapitulated. Additionally, formulations responsive to multiple stimuli are mentioned. Focusing on chitosan-based smart hydrogels, their multifaceted utilization was thoroughly described. The vast application spectrum encompasses neurological disorders, tumors, wound healing, and dermal infections. Available data on smart chitosan hydrogels strongly support the idea that current approaches and developing novel solutions are worth improving. The present paper constitutes a valuable resource for researchers and practitioners in the currently evolving field.

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“…Overall, the study highlights the development of a smart injectable PHIS encapsulating hydrogel which not only proves to be safe and biocompatible but also demonstrates considerable therapeutic efficacy in the context of RA. [124] While tolerogenic dendritic cell-derived exosomes (TolDex) demonstrates potential as effective treatments for RA, their clinical utilization has been limited because of low distribution within the blood. In this context, Lee et al, present the fabrication of ROS-sensitive TolDex that has the ability to trigger sitespecific immunoregulation in RA.…”

Section: Rheumatoid Arthritismentioning

confidence: 99%

Section: Stimuli‐responsive Nanoparticles For Combating Different Dis...mentioning

confidence: 99%

Harnessing the Power of Stimuli‐Responsive Nanoparticles as an Effective Therapeutic Drug Delivery System

Fatima,

Almalki,

Khan

et al. 2024

Advanced Materials

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The quest for effective and reliable methods of delivering medications, with the aim of improving delivery of therapeutic agent to the intended location has presented a demanding yet captivating field in biomedical research. The concept of smart drug delivery systems is an evolving therapeutic approach, serving as a model for directing drugs to specific targets or sites. These systems have been developed to specifically target and regulate the administration of therapeutic substances in a diverse array of chronic conditions, including periodontitis, diabetes, cardiac diseases, inflammatory bowel diseases, rheumatoid arthritis, and different cancers. Nevertheless, numerous comprehensive clinical trials are still required to ascertain both the immediate and enduring impacts of such nanosystems on human subjects. This review delves into the benefits of different drug delivery vehicles, aiming to enhance comprehension of their applicability in addressing present medical requirements. Additionally, it touches upon the current applications of these stimuli‐reactive nanosystems in biomedicine and outlines future development prospects.This article is protected by copyright. All rights reserved

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Thermosensitive smart hydrogel of PEITC ameliorates the therapeutic efficacy in rheumatoid arthritis

Cited by 16 publications

References 97 publications

Development of biomedical hydrogels for rheumatoid arthritis treatment

Development of biomedical hydrogels for rheumatoid arthritis treatment

Biomedical Trends in Stimuli-Responsive Hydrogels with Emphasis on Chitosan-Based Formulations

Harnessing the Power of Stimuli‐Responsive Nanoparticles as an Effective Therapeutic Drug Delivery System

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