Thiabendazole Effectiveness In Creeping Eruption

Stone, Orville J.

doi:10.1001/archderm.1965.01600110013004

Cited by 37 publications

(17 citation statements)

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“…However, the unpredictable duration and severity generally leads to intervention. The suggested treatment options include local cryosurgery, topical or oral thiabendazole, oral albendazole, or oral ivermectin (Stone and Mullins, 1965;Bouchaud et al, 2000;Blackwell and VegaLopez, 2001). Physical modalities for CLM such as cryotherapy and surgical excision are often ineffective, as the larva is usually 1-2 cm ahead of the visible tract and can easily be missed, even though these modalities may be appropriate in pregnancy (Blackwell and Vega-Lopez, 2001).…”

Section: Discussionmentioning

confidence: 99%

“…Physical modalities for CLM such as cryotherapy and surgical excision are often ineffective, as the larva is usually 1-2 cm ahead of the visible tract and can easily be missed, even though these modalities may be appropriate in pregnancy (Blackwell and Vega-Lopez, 2001). Oral thiabendazole has been reported to have a very high efficacy and is usually given at a dose of 25 mg/kg twice daily for 3 days (Stone and Mullins, 1965). The pruritus subsides by the first day, and the lesions clear within 1 to 2 weeks.…”

Section: Discussionmentioning

confidence: 99%

“…The pruritus subsides by the first day, and the lesions clear within 1 to 2 weeks. However, there is a relatively high incidence of side-effects including nausea, anorexia, headache and gastrointestinal disturbances (Stone and Mullins, 1965). Oral albendazole and topical thiabendazole as a 15% cream are also effective, particularly in the early phase.…”

Section: Discussionmentioning

confidence: 99%

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A serologically diagnosed human case of cutaneous larva migrans caused by Ancylostoma caninum

et al. 2003

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Abstract:A 15-year-old boy, who had recently arrived back from a trip to Cambodia for a missionary camp, presented with several serpiginous thread-like skin lesions that began as small papules on the left upper extremities 2 weeks before his visit to Hospital. The skin lesions were pruritic and erythematous, and had migrated to the chest and abdomen. The histopathological findings showed only lymphocytic and eosinophilic infiltrations in the dermis of the biopsied skin lesion. The patient's serum reacted strongly to the Ancylostoma caninum antigen by an ELISA method. Therefore, he was diagnosed with cutaneous larva migrans by A. caninum. After the oral administration of albendazole and ivermectin, the skin lesions resolved without recurrence. This is the first reported case of a cutaneous larva migrans caused by Ancylostoma canimum diagnosed serologically using ELISA in Korea. et al., 1995;Lim et al., 1996;Chang et al., 1999;Kim et al., 1999;Suh et al., 2003). We report a case of CLM due to A. caninum that was believed to be the result of an infection obtained in Cambodia during a missionary camp and was diagnosed serologically using ELISA. CASE RECORDIn July 2002, a 15-year-old boy visited the Seoul National University Hospital with a skin eruption on his left upper extremity, chest and abdomen, which had been presented for 2 weeks. The skin lesions were linear, serpiginous, elevated and erythematous (Fig. 1). It produced an intense itching sensation, and scaly plaque was observed on the surface of the lesions. He had returned from a trip to Cambodia for a missionary camp one week before the skin lesions erupted, but he denied any risk activities of cutaneous larva migrans such as walking barefoot on the ground or sun-bathing at the beach during his stay in Cambodia.The laboratory findings revealed an increased number of WBC (19,060/mm 3 ) with a normal eosinophil count and normal serum IgE level. A stool examination showed no eggs of the parasites and the chest X-ray was within the normal limits. A pathological examination on the biopsied specimen showed only dermal patchy infiltrations of 234 Korean J. Parasitol. Vol. 41, No. 4. 233-237, December 2003 Fig. 1. Erythematous linear elevated serpiginous plaques on the left upper extremities (A) and the abdomen (B).

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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A serologically diagnosed human case of cutaneous larva migrans caused by Ancylostoma caninum

et al. 2003

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“…For this reason, the use of liquid nitrogen on the leading edge of the track is a very imprecise way to localize and kill the migrating larva (Kurgansky and Burnett, 1990). Treatment with topical and systemic thiabendazole appears to be highly successful (Edelglas et al, 1982;Jacksonville Dermatology Society, 1965;Stone and Mullins, 1965). However, side effects seen in oral thiabendazole administration include dizziness, anorexia, nausea, vomiting, and diarrhea, which resolve once the therapy is discontinued (Stone and Mullins, 1965).…”

Section: Discussionmentioning

confidence: 99%

“…Treatment with topical and systemic thiabendazole appears to be highly successful (Edelglas et al, 1982;Jacksonville Dermatology Society, 1965;Stone and Mullins, 1965). However, side effects seen in oral thiabendazole administration include dizziness, anorexia, nausea, vomiting, and diarrhea, which resolve once the therapy is discontinued (Stone and Mullins, 1965). Ivermectin, a new derivative of avermectin B, looks very promising as a new therapeutic modality, but more experience is required before recommending it for routine use in treating CLM (Davies et al, 1993).…”

Section: Discussionmentioning

confidence: 99%