Thiamine mediated reversal of left ventricular dysfunction in patients with alcoholic cardiomyopathy

Satish, Oruganti Sai; Shaik, Shabbir Ali

doi:10.1016/j.ihj.2021.03.013

Cited by 4 publications

(4 citation statements)

References 5 publications

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“…The results were consistent with a previous report [14]. The cause of QT prolongation was presumed to be due to the direct toxic effects of alcohol and thiamine deficiency, but detailed mechanisms remain unclear [15,16]. Administering drugs with QT prolongation action should be avoided or used with close ECG monitoring in the population, though it was reported that QT prolongation did not significantly influence in-hospital mortality [17].…”

Section: Discussionsupporting

confidence: 90%

Alcoholic cardiomyopathy in patients with alcoholic liver cirrhosis: a study across 10 years

Wang

Gao

Liu

et al. 2023

European Journal of Gastroenterology &Amp; Hepatology

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Background and objectives Available data regarding cardiomyopathy in patients with alcoholic liver cirrhosis (ALC) are very limited because it often requires multidisciplinary assessments. The study aims to evaluate the prevalence of alcoholic cardiomyopathy in ALC and their clinical correlations. Methods Adult ALC patients without a previous diagnosis of cardiovascular diseases between January 2010 and December 2019 were included in the study. The prevalence rate of alcoholic cardiomyopathy in patients with ALC was calculated together with a 95% confidence interval (CI) using the Clopper–Pearson exact method. Results A total of 1022 ALC patients were included. Male patients predominated (90.5%). ECG abnormalities were observed in 353 patients (34.5%). Prolonged QT interval was most common in ALC patients with ECG abnormalities, which occurred in 109. Thirty-five ALC patients underwent the cardiac MRI examination and only one patient was found with cardiomyopathy. The estimated prevalence rate of alcoholic cardiomyopathy in all the ALC patients was 0.0286 (95% CI, 0.0007–0.1492). There was no statistical difference regarding the prevalence rate between the group of patients with ECG abnormalities and the group without ECG abnormalities (0.0400 vs. 0.0000, P = 1.000). Conclusion Although ECG abnormalities, especially QT prolongation, existed in a proportion of ALC patients, cardiomyopathy in the patient population was not common. Further larger-sample studies based on cardiac MRI are needed to verify our results.

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Section: Discussionsupporting

confidence: 90%

Alcoholic cardiomyopathy in patients with alcoholic liver cirrhosis: a study across 10 years

Wang

Gao

Liu

et al. 2023

European Journal of Gastroenterology &Amp; Hepatology

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“…Vitamin and/or mineral deficiencies can occur in chronic liver disease. Thiamine supplementation should be considered in severely alcoholic patients ( Satish and Shaik, 2021 ). Fat-soluble vitamin supplementation should be considered in conditions of cholestatic ( Atarashi et al., 2017 ).…”

Section: Targeting Gut-microbiota To Manage Chronic Liver Diseasementioning

confidence: 99%

Gut Microbiota Targeted Approach in the Management of Chronic Liver Diseases

Liu

Yang

Wang

et al. 2022

Front. Cell. Infect. Microbiol.

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The liver is directly connected to the intestines through the portal vein, which enables the gut microbiota and gut-derived products to influence liver health. There is accumulating evidence of decreased gut flora diversity and alcohol sensitivity in patients with various chronic liver diseases, including non-alcoholic/alcoholic liver disease, chronic hepatitis virus infection, primary sclerosing cholangitis and liver cirrhosis. Increased intestinal mucosal permeability and decline in barrier function were also found in these patients. Followed by bacteria translocation and endotoxin uptake, these will lead to systemic inflammation. Specific microbiota and microbiota-derived metabolites are altered in various chronic liver diseases studies, but the complex interaction between the gut microbiota and liver is missing. This review article discussed the bidirectional relationship between the gut and the liver, and explained the mechanisms of how the gut microbiota ecosystem alteration affects the pathogenesis of chronic liver diseases. We presented gut-microbiota targeted interventions that could be the new promising method to manage chronic liver diseases.

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“…A wide range of presentations related to vitamin deficiencies in alcohol consumers may be visible in the oral cavity, such as inflammatory changes, hemorrhages, ulcers, precancerosis, sensory presentations, or salivary gland problems [ 122 ]. Alcohol consumption decreases the transport of thiamine (vitamin B1) across the intestinal mucosa, decreases the storage of thiamine in the liver, and impairs the activation by inhibiting thiamine phosphorylation to thiamine diphosphate [ 123 ]. Thiamine is vital in energetic metabolism, and thiamine deficiency may associate with cardiovascular diseases in alcohol consumers [ 124 ].…”

Section: Toxicity Of Ethanolmentioning

confidence: 99%

“…The mechanism of myocyte damage is related to the reduction of mitochondrial proteosynthesis, mitochondria damage, oxidative stress, apoptosis, modification of contractile proteins actin and myosin, lysosomal proteases-mediated loss of individual myocardial proteins, and disturbances in calcium metabolism [ 154 , 156 , 160 ]. Although alcoholic cardiomyopathy should be independent of nutrition and vitamins [ 161 ], thiamine supplementation can improve the ejection fraction in patients with alcoholic cardiomyopathy [ 123 ]. Alcohol-induced FAEEs bound to the mitochondrial membrane in myocytes cause mitochondrial dysfunction by impaired coupling of the respiratory chain with oxidative phosphorylation [ 162 ].…”

Section: Toxicity Of Ethanolmentioning

confidence: 99%

Current View on the Mechanisms of Alcohol-Mediated Toxicity

Birková

Hubková

Čižmárová

et al. 2021

IJMS

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Alcohol is a psychoactive substance that is widely used and, unfortunately, often abused. In addition to acute effects such as intoxication, it may cause many chronic pathological conditions. Some of the effects are very well described and explained, but there are still gaps in the explanation of empirically co-founded dysfunction in many alcohol-related conditions. This work focuses on reviewing actual knowledge about the toxic effects of ethanol and its degradation products.

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Thiamine mediated reversal of left ventricular dysfunction in patients with alcoholic cardiomyopathy

Cited by 4 publications

References 5 publications

Alcoholic cardiomyopathy in patients with alcoholic liver cirrhosis: a study across 10 years

Alcoholic cardiomyopathy in patients with alcoholic liver cirrhosis: a study across 10 years

Gut Microbiota Targeted Approach in the Management of Chronic Liver Diseases

Current View on the Mechanisms of Alcohol-Mediated Toxicity

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