Thiazolidine, a versatile ring in the treatment of various diseases: A systematic review

Bajpai, P.D.; Jain, Shelesh; Choubey, Ankur

doi:10.5958/0974-4150.2020.00055.3

Cited by 4 publications

(3 citation statements)

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“…Likewise, thiazolidine-2,4-dione derivatives are extensively studied for their exceptional antioxidant properties [ 67 ]. Heterocyclic compounds containing the thiazolidine portion play an important role in the field of medicinal chemistry, presenting a wide range of biological activities, from antihypertensive to simple anti-inflammatory activity [ 68 ].…”

Section: Discussionmentioning

confidence: 99%

Neurolocomotor Behavior and Oxidative Stress Markers of Thiazole and Thiazolidinedione Derivatives against Nauphoeta cinerea

et al. 2022

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Thiazolidine compounds NJ20 {(E)-2-(2-(5-bromo-2-methoxybenzylidene)hydrazinyl)-4-(4-nitrophenyl)thiazole} and NW05 [(2-(benzo (d) (1,3) dioxol-4-ylmethylene)-N-(4-bromophenyl)-thiosemicarbazone] potentiated the effect of norfloxacin in resistant bacteria; however, there are no reports on their effects on Nauphoeta cinerea in the literature. The objective of this work was to evaluate the behavioral effects and oxidative markers of NW05 and NJ20 in lobster cockroach N. cinerea. To evaluate the behavioral study, a video tracking software was used to evaluate the locomotor points and the exploratory profile of cockroaches in the horizontal and vertical regions of a new environment. The total concentration of thiol and reduced glutathione (GSH), substances reactive to thiobarbituric acid (TBARS), free iron (II) content and mitochondrial viability were determined. The antioxidant potential was evaluated by the DPPH method. Both substances induced changes in the behavior of cockroaches, showing a significant reduction in the total distance covered and in the speed. In the cell viability test (MTT), there was a significant reduction for NJ20 (1 mM). NJ20 caused a significant increase in total levels of thiol and non-protein thiol (NPSH), although it also slightly increased the content of malondialdehyde (MDA). Both compounds (NW05 and NJ20) caused a significant reduction in the content of free iron at a concentration of 10 mM. In conclusion, the compound NJ20 caused moderate neurotoxicity (1 mM), but had good antioxidant action, while NW05 did not show toxicity or significant antioxidant activity in the model organism tested. It is desirable to carry out complementary tests related to the antioxidant prospection of these same compounds, evaluating them at different concentrations.

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Section: Discussionmentioning

confidence: 99%

Neurolocomotor Behavior and Oxidative Stress Markers of Thiazole and Thiazolidinedione Derivatives against Nauphoeta cinerea

et al. 2022

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“…24,25,29,30 Similarly, thiazolidine derivatives also exhibit antiviral, anti-inflammatory, antifungal, antimicrobial, antibacterial, and anticancer activities. [31][32][33] The biological importance of the above heterocyclic compounds has encouraged research on the synthesis of quinoline derivatives [34][35][36][37] and spiro-hetero-cycles [38][39][40][41] through dipolar cycloaddition reactions 34,37,42 in order to generate spiro-heterocycles possessing thiadiazole, thiazolidine, and 2-chloroquinoline motifs.…”

Section: Paper Synthesismentioning

confidence: 99%

Regio- and Chemoselective Synthesis of 4,6-Dithia-1,2,9-triazaspiro[4.4]non-2-en-8-ones through an Ultrasound-Promoted One-Pot Sequential Pseudo-Five-Component Reaction

Alizadeh,

Chelebari,

Rezaiyehraad

2024

Synthesis

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Spiro-heterocycles have attracted significant interest due to their unique biological properties with fewer side effects compared to traditional drugs. Herein, a novel method is reported for the synthesis of a series of spiro-heterocycles possessing a quinoline motif. The strategy utilizes rhodanine derivatives, hydrazonoyl chlorides, and 2-chloroquinoline-3-carbaldehyde, and proceeds via a one-pot sequential pseudo-five-component reaction. The reactions are found to proceed in a regioselective and chemoselective manner.

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“…The thiazolidine nucleus can be modified in different ways to obtain a wide variety of derivatives. Although many derivatives of this nucleus have been synthesized and evaluated for different biological activities, which highlight its importance [ 21 , 22 ], new derivatives can be designed having potential biological activities. Thiazolidine-4-carboxylic derivatives reported so far have been modified at position 2 with a free carboxylic acid group at position 4.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, In Silico Studies, and Antioxidant and Tyrosinase Inhibitory Potential of 2-(Substituted Phenyl) Thiazolidine-4-Carboxamide Derivatives

et al. 2023

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Heterocyclic nuclei have shown a wide variety of biological activities, highlighting their importance in drug discovery. Derivatives of 2,4-subsituted thiazolidine have a structural similarity with the substrates of tyrosinase enzymes. Hence, they can be used as an inhibitor to compete against tyrosine in the biosynthesis of melanin. This study is focused on design, synthesis, biological activities, and in silico studies of thiazolidine derivatives substituted at positions 2 and 4. The synthesized compounds were evaluated to determine the antioxidant activity and tyrosine inhibitory potential using mushroom tyrosinase. The most potent tyrosinase enzyme inhibitor was compound 3c having IC50 value 16.5 ± 0.37 µM, whereas compound 3d showed maximum antioxidant activity in a DPPH free radical scavenging assay (IC50 = 18.17 µg/mL). Molecular docking studies were conducted using mushroom tyrosinase (PDB ID: 2Y9X) to analyze binding affinities and binding interactions of the protein–ligand complex. Docking results indicated that hydrogen bonds and hydrophobic interactions were mainly involved in the ligand and protein complex. The highest binding affinity was found to be −8.4 Kcal/mol. These results suggest that thiazolidine-4-carboxamide derivatives could serve as lead molecules for development of novel potential tyrosinase inhibitors.

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Thiazolidine, a versatile ring in the treatment of various diseases: A systematic review

Cited by 4 publications

References 0 publications

Neurolocomotor Behavior and Oxidative Stress Markers of Thiazole and Thiazolidinedione Derivatives against Nauphoeta cinerea

Neurolocomotor Behavior and Oxidative Stress Markers of Thiazole and Thiazolidinedione Derivatives against Nauphoeta cinerea

Regio- and Chemoselective Synthesis of 4,6-Dithia-1,2,9-triazaspiro[4.4]non-2-en-8-ones through an Ultrasound-Promoted One-Pot Sequential Pseudo-Five-Component Reaction

Synthesis, In Silico Studies, and Antioxidant and Tyrosinase Inhibitory Potential of 2-(Substituted Phenyl) Thiazolidine-4-Carboxamide Derivatives

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