“…Furthermore, troglitazone metabolites, which circulate at high concentrations in chronically treated rats, may signi®cantly contribute to its long-term action in vivo (Ciaraldi et al, 1995;Khourshed et al, 1995). Beside stimulation of glucose uptake in vivo and in vitro Okuno et al, 1997), short-term exposure to troglitazone or other thiazolidine derivatives triggers a number of further insulin-like responses (Fujiwara et al, 1988;Zhang et al, 1994;Maegawa et al, 1995). However, with regard to isolated muscle glucose handling, insulin-induced glucose uptake is associated with an anabolic response characterized by distinct augmentation of glycogenesis, moderate stimulation of glycolysis and glycogen accumulation (Crettaz et al, 1980;FuÈ rnsinn et al, 1995; and this study).…”