Thiazolyl/oxazolyl formazanyl indoles as potent anti-inflammatory agents

Synthesis and pharmacological evaluation of a novel series of 3-aryl-2-(2-substituted-4-methylthiazole-5-yl)thiazolidin-4-one as possible anti-inflammatory and antimicrobial agents

“…Concurring with previous reports, thiazolyl/formazanyl indols, 36 admantane derivatives of thiazolyl-N-substituted amide, 37 2-amino-5-thiazolyl motif, 38 2-(2,4-disubstituted thiazol-5-yl)-3-aryl-3Hquinazoline-4-one 39 and thiazolyl derivatives of 1-H pyrazole 40 have shown anti-inflammatory and antimicrobial activities. Literature also revealed that thiazolidinone nucleus at 2-position of thiazole showed good antifungal 41 and antiviral 42 activities.…”

Montmorillonite K10: an effective catalyst for synthesis of 2-aminothiazoles

“…Thiazole and its derivatives are one of the main components in a variety of natural compounds [2]. Meanwhile, 2-aminothiazole derivatives as a subgroup of thiazole family are important because of their medical applications as anti-HIV, antidiabetic, antibacterial, antifungal, anti-oxidant, antitubercular, anti-inflammatory, anticancer, antihypertensive, and neuroprotective [3][4][5][6][7][8]. Also, there is an appropriate attention to this class of compounds in synthetic organic and medicinal chemistry.…”

Synthesis and biological evaluation of 3-(1H-indol-3-yl)pyrazole-5-carboxylic acid derivatives

“…A number of indole derivatives possess interesting activities such as antiinflammatory (Singh et al, 2008), endothelin antagonist (Rawson et al, 2002), antifungal (Basavarajaiah and Mruthyunjayaswamy, 2009) and antibacterial (Yamamoto and Kurazono, 2007) activities. Pyrazole, the potent basic pharmacophore, has been associated with various biological properties, viz.…”