Thieno[3,4‐c]quinoline‐4‐yl‐amines — Synthesis and Investigation of Activity Against Malaria.

Abstract

Fused pyridine derivatives R 0450Thieno[3,4-c]quinoline-4-yl-amines -Synthesis and Investigation of Activity Against Malaria. -The thieno[3,4-c]quinoline (VI), obtained via Suzuki cross coupling followed by pH-dependent cyclization and chlorination, is used as key precursor for the synthesis of a series of potential antimalarial substances. In vitro testing using the chloroquine-sensitive 3D7 and the chloroquine-resistant strain Dd2 reveal compound (Xb) as the most potent in the series. -(GOERLITZER*, K.; GABRIEL, B.; JOMAA, H.; WIESNER, J.; Pharmazie 61 (2006) 11, 901-907; Inst. Pharm. Chem.,