Fused pyridine derivativesFused pyridine derivatives R 0450 Thieno[2,3-c]quinolines -Synthesis and Biological Investigation. -Compound (VIIIb) shows antimalarial activity. -(GOERLITZER*, K.; GABRIEL, B.; FROHBERG, P.; WOBST, I.; DRUTKOWSKI, G.; WIESNER, J.; JOMAA, H.;

Fused pyridine derivatives R 0450 Thieno[3,2-c]quinoline-4-yl-amines -Synthesis and Investigation of Activity Against Malaria. -A variety of the title thienoquinolinylamines [cf. (VII), (IX)] and isomeric thieno[2,3-c]quinoline derivatives [cf. (X)] is synthesized and evaluated for in vitro growth inhibition of malaria parasites. Pyronaridine derivative (VIIc) proves to be the most active compound. -(GOERLITZER*, K.; GABRIEL, B.; JOMAA, H.; WIESNER, J.; Pharmazie 61 (2006) 4, 278-284; Inst. Pharm.

Fused pyridine derivatives R 0450Thieno[3,4-c]quinoline-4-yl-amines -Synthesis and Investigation of Activity Against Malaria. -The thieno[3,4-c]quinoline (VI), obtained via Suzuki cross coupling followed by pH-dependent cyclization and chlorination, is used as key precursor for the synthesis of a series of potential antimalarial substances. In vitro testing using the chloroquine-sensitive 3D7 and the chloroquine-resistant strain Dd2 reveal compound (Xb) as the most potent in the series. -(GOERLITZER*, K.; GABRIEL, B.; JOMAA, H.; WIESNER, J.; Pharmazie 61 (2006) 11, 901-907; Inst. Pharm. Chem.,

No abstract

No abstract