Thigh Abscess Caused by<i>Yersinia enterocolitica</i>in an Immunocompetent Host

Gumaste, Purva; Boppana, V. Subbarao; Garcha, Amarinder Singh; Blair, Donald C.

doi:10.1155/2012/259475

Cited by 2 publications

(2 citation statements)

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“…[ 1 , 2 ] Abscess formation is also usually caused by septicemia in immunocompromised hosts. [ 3 – 5 ] Our case showed no evidence of septicemia or gastrointestinal symptoms, so the pathogen was inferred to have directly entered into the tissue from some environmental source through a weakened skin barrier. In several past cases, portal entry also involved a failure of the skin barrier.…”

Section: Discussionmentioning

confidence: 85%

Primary cellulitis and cutaneous abscess caused by Yersinia enterocolitica in an immunocompetent host

2016

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Primary extraintestinal complications caused by Yersinia enterocolitica are extremely rare, especially in the form of skin and soft-tissue manifestations, and little is known about their clinical characteristics and treatments. We presented our case and reviewed past cases of primary skin and soft-tissue infections caused by Y enterocolitica. We report a case of primary cellulitis and cutaneous abscess caused by Y enterocolitica in an immunocompetent 70-year-old woman with keratodermia tylodes palmaris progressiva. She presented to an outpatient clinic with redness, swelling, and pain of the left ring finger and left upper arm without fever or gastrointestinal symptoms 3 days before admission. One day later, ulceration of the skin with exposed bone of the proximal interphalangeal joint of the left ring finger developed, and cefditoren pivoxil was described. However, she was admitted to our hospital due to deterioration of symptoms involving the left finger and upper arm. Cefazolin was initiated on admission, then changed to sulbactam/ampicillin and vancomycin with debridement of the left ring finger and drainage of the left upper arm abscess. Wound culture grew Y enterocolitica serotype O:8 and methicillin-sensitive Staphylococcus aureus. Blood cultures were negative and osteomyelitis was ruled out. Vancomycin was switched to ciprofloxacin, then skin and soft-tissue manifestations showed clear improvement within a few days. The patient received 14 days of ciprofloxacin and oral amoxicillin/clavulanate and has since shown no recurrence. We reviewed 12 cases of primary skin and soft-tissue infections caused by Y enterocolitica from the literature. In several past cases, portal entry involved failure of the skin barrier on distal body parts. Thereafter, infection might have spread to the regional lymph nodes from the ruptured skin. Y enterocolitica is typically resistant to aminopenicillins and narrow-spectrum cephalosporins. In most cases, these inefficient antibiotic agents were initially prescribed, but patient conditions rapidly improved after implementing appropriate therapy and drainage. In addition, primary skin and soft-tissue infections occurred even in patients lacking risk factors. Physicians should consider the rare differential diagnosis of Y enterocolitica infection when seeing patients with deteriorating skin lesions under standard treatment, even if the patient is immunocompetent.

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Section: Discussionmentioning

confidence: 85%

Primary cellulitis and cutaneous abscess caused by Yersinia enterocolitica in an immunocompetent host

2016

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“…Wskazane jest również rozpatrzenie włączenia antybiotyków do leczenia jersiniozy u osób z obniżoną odpornością lub chorobami towarzyszącymi (16,33). Pałeczki Y. enterocolitica wykazują wrażliwość na szerokie spektrum antybiotyków oraz chemioterapeutyków stosowanych w terapii zakażeń ludzi i zwierząt (3,14,18). W leczeniu jersiniozy obecnie zaleca się stosowanie cefalosporyny III generacji, również w połączeniu z makrolidami, aminoglikozydami lub fluorochinolami (16).…”

Section: Wstępunclassified

Presence of β-lactamase encoding genes in clinical isolates of Y. enterocolitica bioserotype 1B/O8mm isolated in Poland in 2009

Zacharczuk¹

2018

Med Dosw Mikrobiol

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Introduction: The intrinsic resistance to β-lactam antibiotics of Y. enterocolitica is mainly due to activity of two type β - lactamases, BlaA and BlaB, which are encoding by genes located on chromosome, blaA and ampC, respectively. High-pathogenicity bioserotype 1B/O8 of Y. enterocolitica has been isolated from clinical samples since 2004 year in Poland. The study shown that clinical isolates of Y. enterocolitica 1B/O8 collected from 2004 to 2009 in Poland constituted the same sensu stricto strain. The aim of present study was to determine the occurrence of genes encoding β-lactamases BlaA and BlaB with the MIC value characterization for selected antibiotics in clinical isolates of Yersinia enterocolitica bioserotype 1B/O isolated in Poland in 2009. Methods: Ampicilin and ticarcillin minimum inhibitory concentrations (MICs) for 64 clinical Y. enterocolitica bioserotype 1B/O8 isolates were determined by Etest and broth microdilution respectively. The blaA i blaB genes were detected by PCR. Results: All investigated isolates were resistant to ticarcillin (MIC 16 – 128 mg/ml), whereas 9,5% to ampicilin (MIC 12 mg/l) according to EUCAST interpretive criteria. All isolates yielded the expected amplicons of blaA and ampC genes. Conclusions: Observed differences in the resistance to ampicillin among analyzed isolates belonging to the epidemic sensu stricto strain can indicate the variable activity of genetic determinants of resistance to β-lactam antibiotics of Y. enterocolitica bioserotype 1B/O8.

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Thigh Abscess Caused byYersinia enterocoliticain an Immunocompetent Host

Cited by 2 publications

References 5 publications

Primary cellulitis and cutaneous abscess caused by Yersinia enterocolitica in an immunocompetent host

Primary cellulitis and cutaneous abscess caused by Yersinia enterocolitica in an immunocompetent host

Presence of β-lactamase encoding genes in clinical isolates of Y. enterocolitica bioserotype 1B/O8mm isolated in Poland in 2009

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