Thigmotropism of Malignant Melanoma Cells

Quatresooz, Pascale; Piérard-Franchimont, C; Noël, Fanchon; Pierard, Gérald

doi:10.1155/2012/362784

Cited by 7 publications

(5 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Primary tumor cells can travel to secondary anatomical sites through established routes such as the blood stream or the lymphatic system 28. Also, a lesser known mechanism, perivascular migration or angiotrophism, involves neoplastic cells migrating along vessels externally to remote sites of the body 29. With the use of our 3D platforms, however, it is now possible to assess not only metastasis and secondary tumor loci development but also the angiotrophic migration of tumor cells in vitro .…”

Section: Resultsmentioning

confidence: 99%

Novel Phenotypic Fluorescent Three-Dimensional Platforms for High-throughput Drug Screening and Personalized Chemotherapy

Fang¹,

Avis²,

Salomon³

et al. 2013

J. Cancer

View full text Add to dashboard Cite

We have developed novel phenotypic fluorescent three-dimensional co-culture platforms that efficiently and economically screen anti-angiogenic/anti-metastatic drugs on a high-throughput scale. Individual cell populations can be identified and isolated for protein/gene expression profiling studies and cellular movement/interactions can be tracked by time-lapse cinematography. More importantly, these platforms closely parallel the in vivo angiogenic and metastatic outcomes of a given tumor xenograft in the nude mouse model but, unlike in vivo models, our co-culture platforms produce comparable results in five to nine days. Potentially, by incorporating cancer patient biopsies, the co-culture platforms should greatly improve the effectiveness and efficiency of personalized chemotherapy.

show abstract

Section: Resultsmentioning

confidence: 99%

Novel Phenotypic Fluorescent Three-Dimensional Platforms for High-throughput Drug Screening and Personalized Chemotherapy

Fang¹,

Avis²,

Salomon³

et al. 2013

J. Cancer

View full text Add to dashboard Cite

show abstract

“…It involves both the active migration of CMM cells and changes in the CMM cell adherence systems with ECM components. Neoplastic thigmotropism is in part involved in the migration path [ 43 ].…”

Section: Tumor Cell Involvement In Micrometastasesmentioning

confidence: 99%

Malignant Melanoma and Its Stromal Nonimmune Microecosystem

Pierard

Piérard-Franchimont

Delvenne

2012

Journal of Oncology

Self Cite

View full text Add to dashboard Cite

In recent years, rapid advances were reached in the understanding of a series of biologic signals influencing cutaneous malignant melanoma (CMM) cells. CMM is in close contact with a peculiar dermal extracellular matrix (ECM). Stromal cells store and release various structural ECM components. The impact on CMM growth and progression is mediated through strong and long-lasting effects of ECM products. This paper summarizes some peculiar aspects of the peri-CMM stroma showing intracytoplasmic loads in Factor XIIIa, CD34, versican, and α (IV) collagen chains. The restricted peri-CMM skin territory exhibiting such changes corresponds to the area showing neoangiogenesis and extravascular unicellular metastatic spread. The latter inconspicuous migratory CMM cells possibly correspond to CMM stem cells or to CMM cells with aberrant HOX gene expression. Their presence is associated with an increased risk for metastases in the regional sentinel lymph nodes. In conclusion, the CMM-stroma connection appears crucial to the growth regulation, invasiveness and initial metastatic spread of CMM cells. Although much remains to be learned in this field, the active intervention of the peri-CMM stroma is likely involved in the inconspicuous early metastatic migration of CMM cells.

show abstract

“…However, pertinent role of the host milieu and/or the microenvironment in tumorigenesis has also been recognized for CMM [6]. Cell mobility and migration in combination with cell proliferation are activated in both the primary CMM and in the metastatic spread [21,24,25]. Cell motility encompasses migration, thigmotropism and invasion, which are key aspects of the metastatic process.…”

Section: Introductionmentioning

confidence: 99%

Functional Regulation Triad of Mitosis, Apoptosis and Thigmotropism of Survivin in Cutaneous Malignant Melanoma

Pierard¹

2016

CRDOA

View full text Add to dashboard Cite

Growth of sporadic Cutaneous Malignant Melanoma (CMM) depends on the combination of the mean tumoral cell cycle time, the growth fraction and the kinesis of the apoptotic programmed cell death. A series of pro-apoptotic and anti-apoptotic regulators have been identified. This review discusses the established mitotic and cytoprotective properties of survivin, and its potential role in CMM development and progression. Other functional properties of survivin are considered, namely enhancement of cellular motility, and thigmotropism which underly the role of this inhibitor of apoptosis protein in promoting overt SMM metastases.

show abstract

Thigmotropism of Malignant Melanoma Cells

Cited by 7 publications

References 58 publications

Novel Phenotypic Fluorescent Three-Dimensional Platforms for High-throughput Drug Screening and Personalized Chemotherapy

Novel Phenotypic Fluorescent Three-Dimensional Platforms for High-throughput Drug Screening and Personalized Chemotherapy

Malignant Melanoma and Its Stromal Nonimmune Microecosystem

Functional Regulation Triad of Mitosis, Apoptosis and Thigmotropism of Survivin in Cutaneous Malignant Melanoma

Contact Info

Product

Resources

About