1983
DOI: 10.1016/s0378-4347(00)84843-4
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Thin-layer chromatographic determination of procainamide and N-acetylprocainamide in human serum and urine at single-dose levels

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1988
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Cited by 6 publications
(2 citation statements)
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“…Procainamide, an anti-arrhythmic drug, is also metabolized mainly by N-acetylation (Kark et al, 1983). Both fast and slow acetylators can develop drug-induced SLE as a result of procainamide therapy, but slow acetylators are more prone to the condition (Reidenberg, 1981).…”
Section: Introductionmentioning
confidence: 99%
“…Procainamide, an anti-arrhythmic drug, is also metabolized mainly by N-acetylation (Kark et al, 1983). Both fast and slow acetylators can develop drug-induced SLE as a result of procainamide therapy, but slow acetylators are more prone to the condition (Reidenberg, 1981).…”
Section: Introductionmentioning
confidence: 99%
“…A small number of methods has been devised to quantitate PA and NAPA simultaneously in plasma by Thin Layer Chromatography (TLC) [ 13 , 14 ], Gas-Liquid Chromatography (GLC) [ 15 ], and HPLC [ 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 ], but most lack sensitivity and/or specificity. Although several UV-HPLC methods achieved sensitivity and specificity improvements, they require multistep sample preparations that involve Liquid–Liquid Extraction (LLE), evaporation, and reconstitution.…”
Section: Introductionmentioning
confidence: 99%