Thin-layer chromatographic screening method for the tranquillizers azaperone, propiopromazine and carazolol in pig tissues

THE EFFECT OF A SLOW-RELEASE FORMULATION OF ZUCLOPENTHIXOL ACETATE (ACUNIL®) ON CAPTIVE BLUE WILDEBEEST (CONNOCHAETES TAURINUS) BEHAVIOR AND PHYSIOLOGICAL RESPONSE

“…The pigs were slaughtered at 2, 5 and 8 hours after injection and Propionylpromazine was found to be present at the injection site and in the kidneys in each of three pigs. Propionylpromazine was present -94 -in the diaphragm muscle in the pigs at 2 and 5 hours WT but not in the muscle of the pig killed at 8 hours WT (Haagsma, Bathelt and Engelsma, 1988).…”

“…It can be used for the detection of the compounds in pig meat and kidney tissue. The method employs a solid phase extraction and two dimensional TLC (Haagsma et al, 1988).…”

“…A TLC procedure was described (Haagsma et al, 1988) for the detection of Propionylpromazine and other tranqilizers and carazolol in pig muscle and kidney with a detection level of 25 g/kg. 20 g of tissue are ground up with alkali and extracted with ether.…”

“…Exposure of Propionylpromazine to light and air also results in the formation of minute quantities of the sulphoxide (Haagsma et al, 1988) and thus the presence of this metabolite may be due to an artifact.…”

Evaluation of thiopentone-midazolam-fentanyl anaesthesia in pigs

“…Attention must be paid to avoiding drug residues in tissues if animals are used for human consumption (Heinritzi & Konig 1988, Haagsma et al 1988, Ganter et al 1990). Recent developments in anaesthesia for use in biomedical research are mainly based on anaesthetics for human use, but little attention appears to be paid to pharmacological variations between species.…”