Think You Know How Smell Works? Sniff Again

Dey, Sandeepa; Stowers, Lisa

doi:10.1016/j.cell.2016.06.006

Cited by 1 publication

(1 citation statement)

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“…The mouse olfactory system comprises a variety of additional subsystems that detect a wide diversity of molecular cues in the external environment (Dey and Stowers, 2016, Munger et al., 2009). We have described a novel subpopulation of sensory neurons in the mouse MOE: type B cells (Omura and Mombaerts, 2014, Omura and Mombaerts, 2015, Saraiva et al., 2015).…”

Section: Introductionmentioning

confidence: 99%

A Sensor for Low Environmental Oxygen in the Mouse Main Olfactory Epithelium

Bleymehl

Pérez-Gómez

Omura

et al. 2016

Neuron

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SummarySensing the level of oxygen in the external and internal environments is essential for survival. Organisms have evolved multiple mechanisms to sense oxygen. No function in oxygen sensing has been attributed to any mammalian olfactory system. Here, we demonstrate that low environmental oxygen directly activates a subpopulation of sensory neurons in the mouse main olfactory epithelium. These neurons express the soluble guanylate cyclase Gucy1b2 and the cation channel Trpc2. Low oxygen induces calcium influx in these neurons, and Gucy1b2 and Trpc2 are required for these responses. In vivo exposure of a mouse to low environmental oxygen causes Gucy1b2-dependent activation of olfactory bulb neurons in the vicinity of the glomeruli formed by axons of Gucy1b2+ sensory neurons. Low environmental oxygen also induces conditioned place aversion, for which Gucy1b2 and Trpc2 are required. We propose that this chemosensory function enables a mouse to rapidly assess the oxygen level in the external environment.

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