2018
DOI: 10.1002/anie.201804971
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Thinking Outside the Box—Novel Antibacterials To Tackle the Resistance Crisis

Abstract: The public view on antibiotics as reliable medicines changed when reports about "resistant superbugs" appeared in the news. While reasons for this resistance development are easily spotted, solutions for re-establishing effective antibiotics are still in their infancy. This Review encompasses several aspects of the antibiotic development pipeline from very early strategies to mature drugs. An interdisciplinary overview is given of methods suitable for mining novel antibiotics and strategies discussed to unrave… Show more

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Cited by 151 publications
(134 citation statements)
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References 379 publications
(965 reference statements)
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“…This fact makes S. aureus one of the most formidable pathogens. In view of its high infection opportunity, particularly for the hospitalized patients, new types of antibacterial agents or therapies not easy to elicit resistance are urgently and desperately needed for disinfection of S. aureus …”
Section: Figurementioning
confidence: 99%
See 1 more Smart Citation
“…This fact makes S. aureus one of the most formidable pathogens. In view of its high infection opportunity, particularly for the hospitalized patients, new types of antibacterial agents or therapies not easy to elicit resistance are urgently and desperately needed for disinfection of S. aureus …”
Section: Figurementioning
confidence: 99%
“…In view of its high infection opportunity,p articularly for the hospitalized patients, new typeso fa ntibacteriala gentso rt herapies not easy to elicit resistance are urgently and desperately needed for disinfection of S. aureus. [5][6][7] While the rapid intrinsic mutation and horizontal gene transfer are responsible for resistance emergencea nd dissemination among bacteria, from the viewpoint of antibiotics, their singletarget character is also ar eason to allow bacteria to readily develop resistance strategies. In this regard,p hotodynamic therapy (PDT),ac linical tumort reatment modality,d isplays promising potential in antibacterial applications as well, the so-called antimicrobial photodynamic therapy (aPDT).…”
mentioning
confidence: 99%
“…Over the past years, mainly human‐induced factors, such as the frequent and careless prescription of antibiotics, have led to immoderate and dramatic proliferation of new resistance strategies among bacteria, causing multiresistant bacterial strains to disseminate faster than the introduction of new antibiotics into clinical application …”
Section: Figurementioning
confidence: 99%
“…[1] Nevertheless,very few novel classes of antibiotics have been introduced to clinics over the last decades. [1] Nevertheless,very few novel classes of antibiotics have been introduced to clinics over the last decades.…”
Section: Introductionmentioning
confidence: 99%
“…[1] Nevertheless,very few novel classes of antibiotics have been introduced to clinics over the last decades. [1] Therefore,d eveloping innovative methods to discover novel druggable targets for antibiotics is apivotal task to guarantee efficient treatment of bacterial infections in the future. [1] Therefore,d eveloping innovative methods to discover novel druggable targets for antibiotics is apivotal task to guarantee efficient treatment of bacterial infections in the future.…”
Section: Introductionmentioning
confidence: 99%