Thinner retinal nerve fibre layer in healthy myopic eyes with thinner central corneal thickness

Arranz-Marquez, Esther; Lauzirika, Gorka; Teus, Miguel A.; Katsanos, Andreas

doi:10.1007/s00417-020-04873-8

Cited by 6 publications

(5 citation statements)

References 16 publications

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“…The patients with OHT with thinner corneas had signi cantly thinner RNFL than the patients with thicker corneas and healthy control subjects. Arranz-Marquez et al measured the CCT and RNFL thickness in healthy subjects with mild to moderate myopia [25]. The mean spherical refractive error in their study group was greater than in our study group (-3.4±1.9 D and -2.74±1.34 D, respectively).…”

Section: Discussioncontrasting

confidence: 68%

Relationship between central corneal thickness and ganglion cell complex thickness in mild to moderate myopia

Kocamis,

Ornek,

Ozcan

2024

ret.vit

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Background: Myopia is not only refractive error, but also an eyesight-threatening disease. To search for a relationship between the central corneal thickness (CCT) and ganglion cell complex (GCC) thickness in patient with myopia.Methods: The prospective cross-sectional study comprised 122 eyes of 122 subjects with mild to moderate myopia. The participants were divided into two groups according to the CCT; thicker than 555 micrometer (Group 1) or thinner than 555 micrometer (Group 2). CCT was measured using the optical biometer machine. All subjects received a slit-lamp examination and optical coherence tomography. The retinal nerve ber layer (RNFL) thickness and GCC thickness were automatically quanti ed.Results: The retinal GCC and GC-IPL thickness were decreased in Group 1 compared with Group 2 (p=0.002 and p=0.007, respectively). The RNFL thickness was statistically signi cantly decreased only in the superior-temporal quadrant (p=0.041). There was a signi cantly positive correlation between p=0.014, and r=0.203, p=0.025, respectively). There was no correlation among CCT and RNFL thickness (p 0.05).Conclusion: There was a relationship between the CCT and GCC thickness in eyes with mild to moderate myopia. BackgroundPatients with myopia have a higher tendency to develop glaucoma [1]. The relationship between these two common ocular disorders may be related to the easily deformable lamina cribrosa due to myopia. Myopic ndings consist of elongated axial length and increased vitreous cavity depth together with changes in connective tissue which can increase the vulnerability of the optic nerve head to the glaucomatous damage [2].Central corneal thickness (CCT) is a substantial parameter in the diagnosis and treatment of glaucoma patients [3][4][5]. Thicker corneas result in arti cially higher intraocular pressure readings [6]. It has been proposed that a thinner cornea is linked to the altered biomechanical and structural characteristics of the posterior sclera and the lamina cribrosa, which may cause a higher vulnerability of the retinal ganglion cell (RGC) to the glaucomatous damage [7]. Previous studies evaluating the correlation between the myopia and the CCT have shown con icting results [8].Glaucoma is an optic neuropathy that can affect all components of the ganglion cell complex (GCC). The ganglion cell layer (GCL) thickness is measured over the macular region, owing to the fact that over 50% of the ganglion cells are localized at this location and the RGC bodies are 10 to 20 times the diameter of their axons [11][12][13]. Due to tilting of the optic disc and peripapillary atrophy, the retinal nerve ber layer (RNFL) measurements may be prone to errors in patients with myopia. Therefore, the thickness of the ganglion cell layer (GCL) and inner plexiform layer (IPL) may have a good ability to detect glaucoma, besides the RNFL thickness [11].In this study, the aim was to search for a relationship between the CCT and the retinal GCC thickness in non-glaucomatous myopic eyes. MethodsThis prospective cross-secti...

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Section: Discussioncontrasting

confidence: 68%

Relationship between central corneal thickness and ganglion cell complex thickness in mild to moderate myopia

Kocamis,

Ornek,

Ozcan

2024

ret.vit

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“…On the other hand, thinner CCT may be associated with thinner NFL. 61 The thinning is likely to be evenly applied to whole profile. Thus it would not be affected by the azimuthal filter.…”

Section: Discussionmentioning

confidence: 99%

Focal Loss Analysis of Nerve Fiber Layer Reflectance for Glaucoma Diagnosis

Tan

Liu

You

et al. 2021

Trans. Vis. Sci. Tech.

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To evaluate nerve fiber layer (NFL) reflectance for glaucoma diagnosis.Methods: Participants were imaged with 4.5 × 4.5 mm volumetric disc scans using spectral-domain optical coherence tomography. The normalized NFL reflectance map was processed by an azimuthal filter to reduce directional reflectance bias caused by variation of beam incidence angle. The peripapillary area of the map was divided into 160 superpixels. Average reflectance was the mean of superpixel reflectance. Lowreflectance superpixels were identified as those with NFL reflectance below the fifth percentile normative cutoff. Focal reflectance loss was measured by summing loss in low-reflectance superpixels.Results: Thirty-five normal, 30 preperimetric, and 35 perimetric glaucoma participants were enrolled. Azimuthal filtering improved the repeatability of the normalized NFL reflectance, as measured by the pooled superpixel standard deviation (SD), from 0.73 to 0.57 dB (P < 0.001, paired t-test) and reduced the population SD from 2.14 to 1.78 dB (P < 0.001, t-test). Most glaucomatous reflectance maps showed characteristic patterns of contiguous wedge or diffuse defects. Focal NFL reflectance loss had significantly higher diagnostic sensitivity than the best NFL thickness parameter (from map or profile): 77% versus 55% (P < 0.001) in glaucoma eyes with the specificity fixed at 99%. Conclusions:Azimuthal filtering reduces the variability of NFL reflectance measurements. Focal NFL reflectance loss has excellent glaucoma diagnostic accuracy compared to the standard NFL thickness parameters. The reflectance map may be useful for localizing NFL defects.Translational Relevance: The high diagnostic accuracy of NFL reflectance may make population-based screening feasible.

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“…In contrast, few studies have reported on the RNFL thickness of the optic papilla in children, especially in children with high myopia. Previous studies have found no connection between the RNFL thickness and myopia and AL in adults using OCT. 10 , 11 Conversely, some studies have found a negative association between the RNFL thickness and AL. 12 The parapapillary retinal RNFL thickness varies in different studies, and the findings of the studies vary in each region.…”

Section: Discussionmentioning

confidence: 99%

Study on the Optic Nerve Fiber Layer Thickness and Changes in Blood Flow in Myopic Children

Lin¹,

Su²,

Lin³

et al. 2021

IJGM

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Objective: The present study aims to observe the optic nerve fiber layer thickness and blood flow density in the papillary area and investigate the effects of axial length (AL) and the refractive state of the optic papilla blood flow density in children with different refractive conditions. Methods: The present study was a clinical control study. The right eyes of 204 minors aged 6-17 years were studied. The eyes were divided into four groups according to myopic refractive states. OCTA analyzed the data to compare the radial peripapillary capillary (RPC) density and the difference in the retinal nerve fiber layer (RNFL) thickness adjacent to the optic papilla between the four refraction groups. Results: The intra-optic disc blood flow density was significantly and negatively correlated with the AL and was negatively correlated with the AL in the inferior temporal quadrants. The RNFL in the superior, nasal, and inferior quadrants was negatively correlated with the AL. The RNFL in the temporal quadrant was positively correlated with the AL. Conclusion: Our present study revealed that aAs myopia increased and the AL grew in children, the blood density of the entire image of the optic papilla, in the optic disc, and the retinal capillaries in the inferior parapapillary and temporal quadrant would change significantly. With increasing AL, a significant decrease in the intra-disc and para-disc RNFL was observed in the superior, nasal, and inferior quadrants, while a substantial increase in RNFL was observed in the temporal quadrant.

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Thinner retinal nerve fibre layer in healthy myopic eyes with thinner central corneal thickness

Cited by 6 publications

References 16 publications

Relationship between central corneal thickness and ganglion cell complex thickness in mild to moderate myopia

Relationship between central corneal thickness and ganglion cell complex thickness in mild to moderate myopia

Focal Loss Analysis of Nerve Fiber Layer Reflectance for Glaucoma Diagnosis

Study on the Optic Nerve Fiber Layer Thickness and Changes in Blood Flow in Myopic Children

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