Thioctic Acid and Acetyl-L-Carnitine in the Treatment of Sciatic Pain Caused by a Herniated Disc

Memeo, Antonio; Loiero, Mario

doi:10.2165/00044011-200828080-00004

Cited by 28 publications

(33 citation statements)

References 17 publications

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“…Three studies 161,172,226 did not report any pain, global or CSOM data. 161,172,226 Fifteen studies compared different types of non-opioids 223,227,229,[231][232][233][234][235][236][237][238][239][240][241] (seven of which were three-arm studies 57,215,223,227,229 and two studies of which were reported in a single publication 223 ). The types of non-opioids being compared are presented in Table 45b but the findings are not considered further.…”

Section: Description Of Non-opioids Studiesmentioning

confidence: 99%

The clinical effectiveness and cost-effectiveness of management strategies for sciatica: systematic review and economic model

Lewis

Williams²,

Matar³

et al. 2011

Health Technol Assess

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How to obtain copies of this and other HTA programme reports An electronic version of this title, in Adobe Acrobat format, is available for downloading free of charge for personal use from the HTA website (www.hta.ac.uk). A fully searchable DVD is also available (see below).Printed copies of HTA journal series issues cost £20 each (post and packing free in the UK) to both public and private sector purchasers from our despatch agents.Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per issue and for the rest of the world £3 per issue. How to order:-fax (with credit card details) -post (with credit card details or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you to either print out your order or download a blank order form. Contact details are as follows:Synergie UK (HTA Department) Digital House, The Loddon Centre Wade Road Basingstoke Hants RG24 8QW Email: orders@hta.ac.uk Tel: 0845 812 4000 -ask for 'HTA Payment Services' (out-of-hours answer-phone service) Fax: 0845 812 4001 -put 'HTA Order' on the fax header Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to University of Southampton and drawn on a bank with a UK address.Paying by credit card You can order using your credit card by phone, fax or post. SubscriptionsNHS libraries can subscribe free of charge. Public libraries can subscribe at a reduced cost of £100 for each volume (normally comprising 40-50 titles). The commercial subscription rate is £400 per volume (addresses within the UK) and £600 per volume (addresses outside the UK). Please see our website for details. Subscriptions can be purchased only for the current or forthcoming volume.How do I get a copy of HTA on DVD?Please use the form on the HTA website (www.hta.ac.uk/htacd/index.shtml). HTA on DVD is currently free of charge worldwide.The website also provides information about the HTA programme and lists the membership of the various committees. HTAThe clinical effectiveness and costeffectiveness of management strategies for sciatica: systematic review and economic model NIHR Health Technology Assessment programmeThe Health Technology Assessment (HTA) programme, part of the National Institute for Health Research (NIHR), was set up in 1993. It produces high-quality research information on the effectiveness, costs and broader impact of health technologies for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined as all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care. The research findings from the HTA programme directly influence decision-making bodies such as the National Institute for Health and Clinical Excellence (NICE) and the National Screening Committee (NSC). HTA findings also help to improve the quality of clinical practice in the NHS indirectly in that they form a key component of the 'National Knowledge Service' . The HTA pro...

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Section: Description Of Non-opioids Studiesmentioning

confidence: 99%

The clinical effectiveness and cost-effectiveness of management strategies for sciatica: systematic review and economic model

Lewis

Williams²,

Matar³

et al. 2011

Health Technol Assess

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“…LA and DHLA are important in the citric-acid cycle and in energy metabolism; in addition, they function as scavengers of free radicals and readily participate in redox reactions that modulate thiol groups in proteins (58). Human and animal studies have clearly documented analgesic properties of LA; however, molecular mechanisms underlying the analgesic properties of LA initially were not understood (7,39). Lee et al (32) used Ca V 3.2 knockout mice to examine molecular determinants of LA inhibition of T-current in DRG cells and in vivo pain responses.…”

Section: Molecular Mechanisms Of Modulation Of Ca V 32 T-current By mentioning

confidence: 99%

Redox Regulation of Neuronal Voltage-Gated Calcium Channels

TodorovicSlobodan

Jevtovic-TodorovicVesna

2014

Antioxidants & Redox Signaling

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Significance: Voltage-gated calcium channels are ubiquitously expressed in neurons and are key regulators of cellular excitability and synaptic transmitter release. There is accumulating evidence that multiple subtypes of voltage-gated calcium channels may be regulated by oxidation and reduction. However, the redox mechanisms involved in the regulation of channel function are not well understood. Recent Advances: Several studies have established that both T-type and high-voltage-activated subtypes of voltage-gated calcium channel can be redoxregulated. This article reviews different mechanisms that can be involved in redox regulation of calcium channel function and their implication in neuronal function, particularly in pain pathways and thalamic oscillation. Critical Issues: A current critical issue in the field is to decipher precise mechanisms of calcium channel modulation via redox reactions. In this review we discuss covalent post-translational modification via oxidation of cysteine molecules and chelation of trace metals, and reactions involving nitric oxide-related molecules and free radicals. Improved understanding of the roles of redox-based reactions in regulation of voltage-gated calcium channels may lead to improved understanding of novel redox mechanisms in physiological and pathological processes. Future Directions: Identification of redox mechanisms and sites on voltage-gated calcium channel may allow development of novel and specific ion channel therapies for unmet medical needs. Thus, it may be possible to regulate the redox state of these channels in treatment of pathological process such as epilepsy and neuropathic pain. Antioxid. Redox Signal. 21, 880-891.

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“…ALC is known to affect the activity of enzymes involved in the energy turnover, thus modulating either different neurotransmitter systems (Picconi et al, 2006;Tolu et al, 2002) or intracellular pathways (Galeotti et al, 2004;Pérez-De La Cruz et al, 2008). A relevant action ascribed to ALC is its anti-nociceptive effect observed in the treatment of painful neuropathies of various origins (Chiechio et al, 2010;Di Cesare Mannelli et al, 2009;Janiri et al, 2009;Memeo and Loiero, 2008;Sima, 2007;Sima et al, 2005). In addition, there is evidence that ALC improves cognitive capabilities (Adriani et al, 2004;Ando et al, 2001;Marini et al, 2006;Shea, 2007).…”

Section: Introductionmentioning

confidence: 99%

Transcription and protein synthesis inhibitors influence long-term effects of acetyl-l-carnitine on non-associative learning in the leech

Traina

Scuri

2015

Neurochemistry International

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Thioctic Acid and Acetyl-L-Carnitine in the Treatment of Sciatic Pain Caused by a Herniated Disc

Cited by 28 publications

References 17 publications

The clinical effectiveness and cost-effectiveness of management strategies for sciatica: systematic review and economic model

The clinical effectiveness and cost-effectiveness of management strategies for sciatica: systematic review and economic model

Redox Regulation of Neuronal Voltage-Gated Calcium Channels

Transcription and protein synthesis inhibitors influence long-term effects of acetyl-l-carnitine on non-associative learning in the leech

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