Thiol/disulphide homeostasis in pregnant women with Familial Mediterranean fever

Yücel, Aykan; Sanhal, Cem Yaşar; Dağlar, Korkut; Kara, Özgür; Uygur, Dilek; Erel, Özcan

doi:10.1080/13510002.2016.1168590

Cited by 20 publications

(19 citation statements)

References 27 publications

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“…However, Erel et al have recently found a cheap, easy, reliable, and fully automated method and the thiol/disulfide balance can be measured by using this technique (14). Using this method revealed that the balance of thiol/disulfide was deteriorated in favor of the disulfide in diseases such as Familial Mediterranean fever, cardiac disease and diabetes mellitus which are characterized with an enhanced oxidative stress (13,38,39). In our study, we showed that FMS patients have lower thiol levels and higher disulfide levels compared to controls.…”

Section: Discussionmentioning

confidence: 99%

Alteration of Thiol-Disulfide Homeostasis in Fibromyalgia Syndrome

Tuzcu

Baykara

Alışık³

et al. 2019

Acta Med. (Hradec Kralove, Czech Repub.)

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Background: Fibromyalgia syndrome (FMS) is an extra-articular rheumatological disease, characterized by widespread pain and somatic symptoms. The etiology has not yet been clarified. Oxidative stress may play an important role in FMS etiology. Thiol group is a very strong antioxidant. We aimed to investigate whether thiol/disulfide homeostasis in FMS is altered or not. Material and methods: A total of 80 female FMS patients and 64 healthy female control individuals were included in this study. Thiol and disulfide values were measured by Erel’s novel methods. Results: Native thiol (330.6 ± 46.1 vs. 356.8 ± 55.5 μmol/L, p = 0.005) and native thiol/total thiol (89.4 ± 3.2 vs. 93.3 ± 4.0, p < 0.001) levels of FMS patients were significantly lower when compared to the values of control group. However, disulfide (19.4 ± 6.3 vs. 12.2 ± 6.3 μmol/L, p < 0.001) levels of FMS patients were significantly higher than healthy individuals. A negative correlation was found between the native thiol/total thiol and fibromyalgia impact questionnaire (FIQ) score among the FMS patients. A positive correlation was found between disulfide values and FIQ score among the patients. Conclusions: In FMS patients, there was a significant correlation between the decrease in the thiol levels and an increase in the disulfide levels with the FIQ scores. We determined that thiol-disulfide rate was deteriorated in FMS patients and it increases in favor of disulfide amounts.

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Section: Discussionmentioning

confidence: 99%

Alteration of Thiol-Disulfide Homeostasis in Fibromyalgia Syndrome

Tuzcu

Baykara

Alışık³

et al. 2019

Acta Med. (Hradec Kralove, Czech Repub.)

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“…Preservation of antioxidant balance and oxidative stress are important for a variety of benign and malignant conditions such as diabetes mellitus and the familial Mediterranean fever as well as for uterine fibroids (16,(29)(30)(31). Relationship between oxidative stress and uterine fibroids was demonstrated in studies regarding surgically removed leiomyomas and found clear interaction between mainly by lipid peroxidation and leiomyoma (32).…”

Section: Inhibition Of Oxidative Stress In the Cell By Amino Acids Anmentioning

confidence: 99%

Level of Certain Oxidants and Antioxidants in Patients with Uterine Fibroids

Çetinkaya

Ayral

Çeti̇nkaya

et al. 2019

Gynecol Obstet Reprod Med

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Objective: The mechanism of the leiomyoma formation process is still unknown. However, the menstrual cycle is associated with hypoxia, and ongoing hypoxia is associated with cellular events leading to the conversion of myometrial cells into uterine fibroids. After the hypoxic environment, the balance of cellular cytokines and growth factors changes. It was planned to evaluate the balance of oxidative agents and the role of oxidative stress in the formation of uterine fibroids.Study Design: The study was conducted in patients of gynecology outpatient clinic of Ankara Oncology Training and Research Hospital. Those volunteers with fibroids formed the study group, and the healthy ones were identified as the control group. A total of 64 subjects, 32 in both groups were included. The levels of catalase, ceruloplasmin, myeloperoxidase, native thiol, disulfide, and total thiol levels were investigated in groups.Results: Antioxidant parameters such as native thiol, disulfide, and total thiol levels were significantly decreased in uterine fibroid group. Catalase, ceruloplasmin, and myeloperoxidase levels were not statistically different between groups.Conclusion: Decrease in these antioxidant parameters showed that the hypoxia and the balance of oxidant and antioxidant substances changes may probably have associated with the pathophysiology of uterine fibroids.

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“…In a study conducted by Yücel et al with FMF-diagnosed pregnant subjects, lower levels of TT and NT and higher disulfide levels were found in FMF patients when compared to controls. The results were found to be more advanced in patients with ante-natal complications (26). In another study of FMF thiol / disulfide balance, it was found that FMF patients had lower levels of NT and TT than controls.…”

Section: Discussionmentioning

confidence: 92%

Ailesel Akdeniz Ateşi olan hastalarda dinamik tiyol / disülfid homeostazının değerlendirilmesi

Doğru¹,

Balkarli²,

Çetin³

et al. 2018

Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi

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Ailesel Akdeniz Ateşi (AAA), ateş ile birlikte tekrarlayan serozal inflamasyon ataklarını içeren, kalıtsal bir otoinflamatuar hastalıktır. Oksidatif stresin belirteci Tiyol / disülfid homeostazı, birçok inflamatuar hastalıkta inflamatuar sitokinlerde artış ile ilişkilidir. Çalışmamızın amacı atak dışı dönemde AAA olan hastalarda dinamik tiyol / disülfid homeostazisini değerlendirmektir. Materyal-Metot: Çalışmamıza atak dışı dönemde 60 AAA'li, 60 inaktif dönemde Ankilozan Spondilit (AS)'li hasta ve 60 yaş ve cinsiyet olarak benzer kontrol grubu dahil edildi. Erel ve Neselioğlu yöntemi kullanılarak nativ tiyol, total tiyol ve disülfid düzeyleri ölçüldü. Bulgular: AAA grubunda total tiyol ve disülfid düzeyleri sağlıklı kontrollere göre anlamlı derecede düşük bulundu. AAA grubunda nativ tiyol düzeylerinin AS grubuna göre anlamlı olarak yüksek olduğu saptandı. Bununla birlikte, AAA ve AS grubu arasında total tiyol düzeylerinde anlamlı bir farklılık izlenmedi. Plazma nativ tiyol, total tiyol ve disülfid seviyeleri kullanılarak elde edilen oranlar, AAA, AS ve kontrol grupları arasında önemli ölçüde farklıydı. Sonuç: AAA hastalarında AS ve control grubuna göre düşük tiyol düzeyi saptanması, farklı patofizyolojiye sahip hastalıklarda tiyol / disülfid dengesinin farklı şekilde etkilendiğini düşündürmektedir. Hastalık klinik olarak inaktif bir dönemde olmasına rağmen, farklı romatizmal hastalıklarda inflamasyon farklı düzeylerde devam edebilir.

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Thiol/disulphide homeostasis in pregnant women with Familial Mediterranean fever

Abstract: The main outcome demonstrates a relation between OS and pregnant women with FMF in the first trimester of gestation. OS in the first trimester may be a major aetiological factor of unfavourable pregancy outcomes in this group of patients.

Cited by 20 publications

References 27 publications

Alteration of Thiol-Disulfide Homeostasis in Fibromyalgia Syndrome

Alteration of Thiol-Disulfide Homeostasis in Fibromyalgia Syndrome

Level of Certain Oxidants and Antioxidants in Patients with Uterine Fibroids

Ailesel Akdeniz Ateşi olan hastalarda dinamik tiyol / disülfid homeostazının değerlendirilmesi

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