Thiol/Disulphide Homeostasis in Thoracic Aortic Aneurysm and Acute Aortic Syndrome

Akkuş, Oğuz; Kaypaklı, Onur; Koca, Hasan; Topuz, Mustafa; Kaplan, Mehmet; Baykan, Ahmet Oytun; Samsa, Muhittin Zafer; Quisi, Alaa; Erel, Özcan; Neşeli̇oğlu, Salim; Gür, Mustafa

doi:10.2217/bmm-2017-0372

Cited by 6 publications

(6 citation statements)

References 22 publications

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“…In a recent study published by Akkuş et al, the native thiol and the total thiol levels were demonstrated to correlate moderately with maximal aortic diameter. The total thiol level was also found to be an independent predictor of maximal aortic diameter in this study, and it was observed that the thiol levels increased after surgical repair of the aorta [1]. Likewise, the total and native thiol levels were lower in the patients with AAD in our study.…”

Section: Discussionsupporting

confidence: 79%

“…As it is a clinically silent disease, it is difficult to assess the true prevalence and incidence of aortic aneurysms. Aortic aneurysms are associated with a rupture risk of more than 5% per year resulting in death [1]. Several mechanisms have been shown to be linked with the development of AAD such as hemodynamic force, destructive remodeling of the extracellular matrix, familial predisposition, transmural inflammation of the aorta, and oxidative stress [2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

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Oxidative stress parameters in patients with ascending aortic dilatation

Erdoğan¹,

Polat²,

Çelik³

et al. 2020

Turk J Med Sci

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Background/aim: This study aimed to determine plasma thiol, disulphide, and serum ischemia-modified albumin (IMA) levels and ferroxidase activity in patients with ascending aorta dilatation (AAD) in comparison to those without AAD and to evaluate the predictive value of these oxidative stress parameters for AAD. Materials and methods: This study was designed as a cross-sectional study of 184 patients who applied to our cardiology clinic. Our study population consisted of patients with AAD (n = 85) and without AAD (n = 99). A spectrophotometric method was used to determine plasma thiol, disulphide, and serum IMA levels and ferroxidase activity. Results: The native thiol and the total thiol levels were significantly higher in the control group than the AAD group (P < 0.001), whereas the disulphide and IMA levels and the ferroxidase activity were similar between the groups. The native thiol and the total thiol levels were inversely and significantly correlated with ascending aortic diameter (r =-0.38, P < 0.001; r =-0.39, P < 0.001; respectively). The left ventricle mass and the total thiol levels were independent predictors of ascending aortic diameter (β= 0.223, P = 0.02; β=-0.340, P < 0.001; respectively). Conclusion: Among oxidative stress parameters including thiols, disulphide, IMA, and ferroxidase activity, only the lower total thiol levels appear to confer a high risk for AAD development. Along with the proven diagnostic imaging methods, thiol levels may be helpful to diagnose and stratify patients with AAD.

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Section: Discussionsupporting

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Oxidative stress parameters in patients with ascending aortic dilatation

Erdoğan¹,

Polat²,

Çelik³

et al. 2020

Turk J Med Sci

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“…Authors have concluded that thiol and disulfide levels are distinctive tests between healthy subjects and aneurysm or acute aortic syndrome [121].…”

Section: Other Disordersmentioning

confidence: 99%

Thiol-disulfide homeostasis: an integrated approach with biochemical and clinical aspects

Erel

Erdoğan

2020

Turk J Med Sci

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Dynamic thiol-disulfide homeostasis (TDH) is a new area has begun to attract more scrutiny. Dynamic TDH is reversal of thiol oxidation in proteins and represents the status of thiols (-SH) and disulfides (-S-S-). Organic compounds containing the sulfhydryl group is called thiol, composed of sulfur and hydrogen atoms. Disulfides are the most important class of dynamic, redox responsive covalent bonds build in between two thiol groups. For many years, thiol levels were analyzed by several methods. During last years, measurements of disulfide levels have been analyzed by a novel automated method, developed by Erel and Neselioglu. In this method, addition to thiol-termed as native thiol-levels, disulfide levels were also measured and sum of native thiol and disulfide levels were termed as total thiol. Therefore, TDH was begun to be understood in organism. In healthy humans, TDH is maintained within a certain range. Dysregulated dynamic TDH has been implicated several disorders with unknown etiology. A growing body of evidence has demonstrated that the thiol-disulfide homeostasis is involved in variety diseases, such as diabetes mellitus, hypertension, non-small cell lung cancer, Familial Mediterranean fever, inflammatory bowel diseases, occupational diseases, gestational diabetes mellitus and preeclampsia. These results may elucidate some pathogenic mechanism or may be a predictor indicating diagnostic clue, prognostic marker or therapeutic sign. In conclusion, protection of the thiol disulfide homeostasis is of great importance for the human being. Evidence achieved so far has proposed that thiol-disulfide homeostasis is an important issue needs to elucidate wholly.

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“…Beyond traditional risk factors for aortic aneurysms such as advanced age, HT and smoking; matrix metalloproteinases (MMPs) and ROS are also considered to be important risk factors in the pathophysiology of AAD (24). In a study published by Akkus et al (2), native thiol and total thiol levels were demonstrated to be correlated with maximal aortic diameter. Total thiol level was also found to be an independent predictor of maximal aortic diameter in this study, and that thiol levels increased after surgical repair of the aorta.…”

Section: Discussionmentioning

confidence: 99%

“…The enlargement of the ascending aorta is defined as aneurysm if it is over the one and a half times the normal diameter. Aortic aneurysm is associated with more than 5% rupture risk per year resulting with death (2). Several local and/or systemic factors have pivotal roles in the pathogenesis of AAD such as increased age, smoking, male gender, familial genetic factors, hemodynamic alterations, inflammation of the aorta, and destructive remodeling of the extracellular matrix (3)(4)(5)(6)(7).…”

Section: Introductionmentioning

confidence: 99%

The Association of The Prolongation Of P-Wave Duration With Ascending Aortic Dilatation In Obese Patients

Doğduş

Koyuncu

Yenerçağ

2020

Harran Üniversitesi Tıp Fakültesi Dergisi

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Background: Ascending aortic dilatation (AAD) is a clinical entity, which is closely related to acute aortic syndromes and can be mortal if not detected at an early stage. Interatrial block (IAB) is a conduction delay between the both atriums and is associated with cardiovascular diseases. We think that IAB may accompany with obese patients with AAD, and the diameter of ascending aorta may be correlated with P-wave duration. Thus, in the current study, we aimed to evaluate the association between AAD and IAB in obese patients. Materials and Methods: A total of 318 consecutive obese subjects who were presented to our outpatient clinic for routine follow-up were enrolled into the study. Standard 12-lead ECGs were recorded. Clinical characteristics, echocardiographic data, and laboratory results of the patients were obtained. Results: The mean age of the patients was 62.7 ± 10.3 years, and 199 (62.5%) of the patients were female. The frequency of IAB was significantly higher and P-wave duration was significantly increased in the AAD (+) patients than in the AAD (-) subjects (p < 0.001 and p < 0.001, respectively). The strongest correlation was found between ascending aortic diameter and P-wave duration (r = 0.713, p < 0.001). In linear regression analysis, P-wave duration (β = 0.695, p < 0.001) and left atrial volume index (LAVI) (β = 0.611, p = 0.005) were found to be independent predictors of ascending aortic diameter. Conclusions: We demonstrated that prolongation of P-wave duration and increased LAVI values were significantly associated with ascending aortic diameter. Therefore, we think that P-wave duration may be used in the follow-up of the AAD patients.

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Thiol/Disulphide Homeostasis in Thoracic Aortic Aneurysm and Acute Aortic Syndrome

Abstract: Lower thiol levels may be associated with the higher risk of aortic aneurysm development and may increase after surgical therapy.

Cited by 6 publications

References 22 publications

Oxidative stress parameters in patients with ascending aortic dilatation

Oxidative stress parameters in patients with ascending aortic dilatation

Thiol-disulfide homeostasis: an integrated approach with biochemical and clinical aspects

The Association of The Prolongation Of P-Wave Duration With Ascending Aortic Dilatation In Obese Patients

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