2017
DOI: 10.1016/j.ejmech.2017.05.023
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Thiosemicarbazones and 4-thiazolidinones indole-based derivatives: Synthesis, evaluation of antiproliferative activity, cell death mechanisms and topoisomerase inhibition assay

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Cited by 66 publications
(13 citation statements)
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“…DNA topoisomerase has been identified at a cellular target for a number of effective antitumor drugs. , Therefore, we used agarose gel electrophoresis to confirm whether Cu agents could inhibit the activity of DNA topoisomerase. It was obvious that 6b can inhibit the activity of both topoisomerase I (Topo I) and topoisomerase II (Topo II) (Figure A,D).…”
Section: Resultssupporting
confidence: 52%
“…DNA topoisomerase has been identified at a cellular target for a number of effective antitumor drugs. , Therefore, we used agarose gel electrophoresis to confirm whether Cu agents could inhibit the activity of DNA topoisomerase. It was obvious that 6b can inhibit the activity of both topoisomerase I (Topo I) and topoisomerase II (Topo II) (Figure A,D).…”
Section: Resultssupporting
confidence: 52%
“…Several studies suggest that compounds with thiazolidinone core have a potent biological activity, such as anti-inflammatory, antibacterial, anticancer, antiviral, antiparasitic, among others [ 7 , 22 , 61 ]. Thiazolidinone could be considered an in vitro hit against T. gondii [ 62 ].…”
Section: Discussionmentioning
confidence: 99%
“…As iron chelators, thiosemicarbazone derivatives have played an important role in organic and medicinal chemistry due to their promising biological activities, which include antiparasitic ( 22 ), anticancer ( 23 , 24 ), anticonvulsant ( 25 ), antiviral ( 26 ), antimicrobial ( 27 , 28 ), and antifungal ( 29 ) effects. For example, 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (Triapine), which exhibits anti-tumor activity, has entered phase II clinical trials and is expected to be used to treat many different types of cancer ( 30 ), and 4-(pyridine-2-yl)-N-([(8E)-5,6,7,8-tetrahydroquinolin-8-ylidene]amino) piperazine-1-carbothioamide (COTI-2) has been evaluated in phase Ib/IIa clinical trials for the treatment of gynecologic malignancies ( 31 ).…”
Section: Introductionmentioning
confidence: 99%