Thiosemicarbazones of Thiophene Derivatives<sup>1</sup>

Campaigne, E.; Monroe, Pearle A.; Arnwine, Bennie C.; Archer, Wesley L.

doi:10.1021/ja01100a507

Cited by 25 publications

(5 citation statements)

References 5 publications

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“…Dimethylthiosemlcarbazone (1,6). Acetone (5.80 g, 0.1 mol) was dissolved in ethanol (50%, 100 ml) and glacial acetic acid (2.0 ml) and thiosemicarbazide (9.10 g, 0.1 mol) added.…”

Section: Methodsmentioning

confidence: 99%

New compounds: potential antituberculous agents. 2. N-Arylformamidino-N'-(dialkyl and diaryl substituted)thiosemicarbazones

Srivastava¹,

Upadhyaya²,

Sharma³

1976

J. Chem. Eng. Data

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“…Dimethylthiosemlcarbazone (1,6). Acetone (5.80 g, 0.1 mol) was dissolved in ethanol (50%, 100 ml) and glacial acetic acid (2.0 ml) and thiosemicarbazide (9.10 g, 0.1 mol) added.…”

Section: Methodsmentioning

confidence: 99%

New compounds: potential antituberculous agents. 2. N-Arylformamidino-N'-(dialkyl and diaryl substituted)thiosemicarbazones

Srivastava¹,

Upadhyaya²,

Sharma³

1976

J. Chem. Eng. Data

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“…Furyl acrolein (1), 4-methoxycinnamaldehyde (2), and 4dimethylaminocinnamaldehyde (3) were synthesised according to procedures set out in the literature [17][18][19].…”

Section: Preparation Of Aryl Acroleins 1-3mentioning

confidence: 99%

Synthesis of methine dyes derived from indol‐2‐ones and their dyeability on polyester fibres

Zhang

Yuan

Zheng

et al. 2013

Coloration Technology

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Three series of methine dyes were synthesised by the condensation of indol‐2‐ones with aryl acroleins. The structures of these dyes were confirmed by 1H nuclear magnetic resonance spectroscopy, infrared spectrometry and elemental analysis. The ultraviolet‐visible absorption spectra of the dyes were examined in different solvents. The maximum absorption wavelength ranged from 386 to 495 nm. The dyes were applied to polyester fibres, and the colour gamut and dyeing properties were investigated. Results showed that the dye uptake (percentage exhaustion) was 86.9–92.0%, with the hue changing from yellow to red. The rubbing fastness, wash fastness, and sublimation fastness were between 4 and 5.

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“…Condensation of appropriate aldehyde or ketone with thiosemicarbazide resulted in the formation of 3-substituted thiosemicarbazones (3,9). A mixture of 3-substitutcd thiosemicarbazone (0.06 mol) and methyl iodide (7.8 g, 0.06 mol) in dry ethanol (10 ml) was heated under reflux for 3 h. Concentration fol lowed by addition of ether yielded 1-methyl l-thio-3-(substituted benzylidcne)-pseudourea hydroiodide which was recrystallized from isopropyl alcohol ether.…”

Section: Synthesis O F Substituted Amino Guanidine Hydroiodidesmentioning

confidence: 99%

Monoamine Oxidase Inhibition by Substituted Benzylideneamino Guanidines and Their CNS Activities

Jaiswal¹,

Gupta²,

Kumar³

et al. 1979

Pharmacology

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The present study reports the synthesis and characterization of eight new substituted benzylideneamino guanidines. All compounds inhibited the monoamine oxidase (MAO) activity of rat brain mitochondria in vitro. The I₅₀ values were determined and were found to be in the range of 10^–4 to 10^–5 mol/l. Preincubation, dialysis and kinetic studies carried out with isolated brain mitochondria by conventional Dixon plot revealed reversible and noncompetitive type of MAO inhibition. These compounds were also screened for anticonvulsant and antidepressant activities. In the present series of compounds only one compound – 1-amino-3-(4-chloromethylbenzylidene-amino)guanidine hydroiodide – was found to afford 20% protection against pentetrazol-induced seizures in mice. 1-Amino-3-(3,4-dichlorobenzylideneamino)guanidine hydroiodide which produced maximum inhibition of MAO activity, also produced reversal of reserpine-induced sedation and miosis into excitation and mydriasis in mice.

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Thiosemicarbazones of Thiophene Derivatives¹

Cited by 25 publications

References 5 publications

New compounds: potential antituberculous agents. 2. N-Arylformamidino-N'-(dialkyl and diaryl substituted)thiosemicarbazones

New compounds: potential antituberculous agents. 2. N-Arylformamidino-N'-(dialkyl and diaryl substituted)thiosemicarbazones

Synthesis of methine dyes derived from indol‐2‐ones and their dyeability on polyester fibres

Monoamine Oxidase Inhibition by Substituted Benzylideneamino Guanidines and Their CNS Activities

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Thiosemicarbazones of Thiophene Derivatives1

Cited by 25 publications

References 5 publications

New compounds: potential antituberculous agents. 2. N-Arylformamidino-N'-(dialkyl and diaryl substituted)thiosemicarbazones

New compounds: potential antituberculous agents. 2. N-Arylformamidino-N'-(dialkyl and diaryl substituted)thiosemicarbazones

Synthesis of methine dyes derived from indol‐2‐ones and their dyeability on polyester fibres

Monoamine Oxidase Inhibition by Substituted Benzylideneamino Guanidines and Their CNS Activities

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Product

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Thiosemicarbazones of Thiophene Derivatives¹