Thioureas in the Synthesis of Heterocycles

Carbon‐11 Radiolabelling of Organosulfur Compounds: 11C Synthesis of the Progesterone Receptor Agonist Tanaproget

“…Simple thioureas typically serve as precursors to larger organic molecules and heterocyclic structures, [27][28][29][30][31][32][33][34] hence radiolabelling such molecules could provide an ovel route to more complex biological molecules. To date, there has only been one reported synthesis of a 11 C radiolabelled thiourea by 11 C methylation to generate an isothiourea, [35] however,l abelling in the thiocarbonyl position has not been previously reported.…”

Thiourea and Thiourea Derivatives

“…2) The polyfunctional character of the thiourea system can be used to synthesize 4-, 5-, 6-, and 7-membered heterocycles [9], [92].…”

Synthesis of N‐Substituted(Thiazol‐2‐ylidene)pyrazol‐5‐amine Derivatives via Condensation of Pyrazolylthioureas with ω‐Bromoacetophenones

“…In the light of these findings, we undertook to investigate the reactions of phenacyl bromides ( 5a , 5c , 5d ) with pyrazolylthioureas 8a , 8b , 8c . As potential nucleophiles, 8a , 8b , 8c offer the sulfur atom, N 1 or N 3 of the thiourea structure , or the endocyclic pyrazole‐NH. On the other hand, compounds 5 offer the active methylene group and the carbonyl atoms as electrophilic sites.…”