Third-Generation Cephalosporin- and Tetracycline-Resistant <i>Escherichia coli</i> and Antimicrobial Resistance Genes from Metagenomes of Mink Feces and Feed

Agga, Getahun E.; Silva, Philip J.; Martin, Randal S.

doi:10.1089/fpd.2020.2851

Cited by 9 publications

(2 citation statements)

References 34 publications

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“…E. coli infections are widespread among humans and other animal species, including fur farmed mink, and are caused by opportunistic bacteria that are commonly isolated from soil and water (OIE, 2018;Zheng et al, 2019;Turner, 2022). Studies have detected E. coli isolates in over 90% of fur farmed mink and feed, with antibioticresistant strains also being identified (Agga et al, 2021). Methicillinresistant Staphylococcus aureus (MRSA) is a widely-acknowledged 'super-bug' affecting human and non-human species, and has been isolated from approximately one-third of fur farmed mink (Larsen et al, 2016).…”

Section: Findings Referencesmentioning

confidence: 99%

One health implications of fur farming

Warwick,

Pilny,

Steedman

et al. 2023

Front. Anim. Sci.

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Fur farming involves the captive-breeding, rearing, and killing of between 85 – 100 million animals annually for their pelts. The purpose of this report is to summarise key areas of significance and concern regarding fur farming, and discuss these matters and their one-health considerations. We conducted primary literature searches using Google Scholar and PubMed that focused on issues of animal welfare, zoonoses and public health, and environmental impacts of fur farming, and examined 280 reports. We identified that at least 15 species are farmed for fur across at least 19 countries. We found 16 categories of animal welfare concern (e.g., deprivation, stress, abnormal behaviours, insanitary conditions, forced obesity, and high morbidity and mortality), 18 reported endemic pathogens and diseases with confirmed or potential zoonotic and cross-species implications (e.g., bacterial n = 6, viral n = 5, and parasitic n = 7), and four main categories of environmental concern (e.g., greenhouse gas emissions, invasive alien species, toxic chemicals, and eutrophication) associated with fur farming. Despite numerous efforts to systematically monitor and control animal welfare at fur farms, practices continue to fail to meet normal scientific principles and models used in other animal welfare situations. In our view, limited available data does not currently indicate that fur farms are major sources of zoonotic epidemics and pandemics. The environmental problems caused by fur farming are significant, and relate mainly to invasive species, toxic chemical release and eutrophication of water bodies. We offer some recommendations for monitoring and controlling particular fur farming practices, in line with many governments and other investigators we conclude that inherent problems are essentially unresolvable and advocate complete prohibitions on the sector.

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Section: Findings Referencesmentioning

confidence: 99%

One health implications of fur farming

Warwick,

Pilny,

Steedman

et al. 2023

Front. Anim. Sci.

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“…Furthermore, many clinical cases of antimicrobial resistance have also been reported in the United States, Denmark, and Canada ( Nikolaisen et al, 2017 ; Cormier et al, 2020 ). The antimicrobial-resistant bacteria detected from the fecal samples belonged to five antimicrobial classes: macrolide–lincosamide–streptogramin B (MLSB; 100% prevalence), TETs (88.1%), β-lactams (71.4%), aminoglycosides (66.7%), and fluoroquinolones (47.6%) ( Agga et al, 2021 ). So it is necessary to develop new antibacterial agents to control P. aeruginosa infections in minks.…”

Section: Introductionmentioning

confidence: 99%

Characterization of a lytic Pseudomonas aeruginosa phage vB_PaeP_ASP23 and functional analysis of its lysin LysASP and holin HolASP

et al. 2023

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In this study, we isolated a lytic Pseudomonas aeruginosa phage (vB_PaeP_ASP23) from the sewage of a mink farm, characterized its complete genome and analyzed the function of its putative lysin and holin. Morphological characterization and genome annotation showed that phage ASP23 belonged to the Krylovirinae family genus Phikmvvirus, and it had a latent period of 10 min and a burst size of 140 pfu/infected cell. In minks challenged with P. aeruginosa, phage ASP23 significantly reduced bacterial counts in the liver, lung, and blood. The whole-genome sequencing showed that its genome was a 42,735-bp linear and double-stranded DNA (dsDNA), with a G + C content of 62.15%. Its genome contained 54 predicted open reading frames (ORFs), 25 of which had known functions. The lysin of phage ASP23 (LysASP), in combination with EDTA, showed high lytic activity against P. aeruginosa L64. The holin of phage ASP23 was synthesized by M13 phage display technology, to produce recombinant phages (HolASP). Though HolASP exhibited a narrow lytic spectrum, it was effective against Staphylococcus aureus and Bacillus subtilis. However, these two bacteria were insensitive to LysASP. The findings highlight the potential of phage ASP23 to be used in the development of new antibacterial agents.

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Dynamics of Extended-spectrum Beta-lactamase–producing, Third-generation Cephalosporin-resistant and Tetracycline-resistant Escherichia coli in Feedlot Cattle With or Without Tylosin Administration

Agga,

Galloway

2023

Journal of Food Protection

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Third-Generation Cephalosporin- and Tetracycline-Resistant Escherichia coli and Antimicrobial Resistance Genes from Metagenomes of Mink Feces and Feed

Cited by 9 publications

References 34 publications

One health implications of fur farming

One health implications of fur farming

Characterization of a lytic Pseudomonas aeruginosa phage vB_PaeP_ASP23 and functional analysis of its lysin LysASP and holin HolASP

Dynamics of Extended-spectrum Beta-lactamase–producing, Third-generation Cephalosporin-resistant and Tetracycline-resistant Escherichia coli in Feedlot Cattle With or Without Tylosin Administration

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