Thirteen-week oral toxicity study of synthetic lycopene products in rats

Mellert, W.; Deckardt, K.; Gembardt, C.; Schulte, Stefan; Ravenzwaay, Bennard van; Slesinski, R.S.

doi:10.1016/s0278-6915(02)00113-8

Cited by 51 publications

(30 citation statements)

References 5 publications

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“…Additionally, the studies investigating the safety of lycopene support this. The deposition of lycopene in plasma, liver, and other tissues had no adverse effects and no teratogenic effects were observed in rat studies (23)(24)(25)(26)(27).…”

Section: Introductionmentioning

confidence: 91%

The effects of lycopene on methotrexate-induced liver injury in rats

Yucel¹,

Oğuz²,

Koçarslan³

et al. 2017

BLL

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BACKGROUND: The aim of this study was to investigate the effects of lycopene (Lyc) on methotrexate (Mtx) induced liver toxicity in rats. METHODS: Twenty-eight male Sprague-Dawley rats were divided into four equal groups: control, Lyc, Mtx and Mtx-L: Control group: Rats were given only the vehicle. Lyc group: Rats were given Lyc (10 mg/kg) with corn oil by oral gavage for ten days. Mtx group: Rats were injected intraperitoneally with a single dose of 20 mg/kg of Mtx and given corn oil by oral gavage. Mtx-L group: Rats were post-treated with Lyc (10 mg/kg) for ten days after a single dose of Mtx (20 mg/kg). RESULTS: Mtx administration increased histopathological damage, TNF-α, IL-1β, TOS, TAS and OSI levels in tissues; AST, ALT levels in the blood. Sinusoidal dilatation, infl ammatory cell infi ltration and congestion were signifi cantly improved in the Mtx-L aon histopathologic examination of the rats. In Mtx-L group that were treated at the Lyc, TNF-α and IL-1β levels of liver tissue were decreased signifi cantly compared to Mtx group whereas the decrease in OSI was not signifi cant. Lyc treatment improved the AST and ALT values in Mtx-L group. But only AST improvement was signifi cant. CONCLUSIONS: The results of this study revealed that Lyc might be useful in protecting the liver from injury due to Mtx in rats by reducing the increased proinfl ammatory cytokine levels (Tab. 4, Fig. 1, Ref. 44). Text in PDF www.elis.sk.

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Section: Introductionmentioning

confidence: 91%

The effects of lycopene on methotrexate-induced liver injury in rats

Yucel¹,

Oğuz²,

Koçarslan³

et al. 2017

BLL

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“…Animal studies also showed the absence of any significant toxicological findings with synthetic lycopene even at very high dose levels. 51,52 Furthermore, the form in which lycopene is administered may also affect its bioavailability. Lycopene in processed foods such as tomato sauce, tomato soup, salsa, ketchup and Lycopene supplementation and prostate cancer progression F Haseen et al tomato paste is more readily bioavailable than fresh tomato, [53][54][55] and lycopene capsules seem to have a bioavailability similar to that of processed tomato.…”

Section: Dose and Methods Of Administration Of Lycopenementioning

confidence: 99%

Is there a benefit from lycopene supplementation in men with prostate cancer? A systematic review

Haseen

Cantwell

O’Sullivan

et al. 2009

Prostate Cancer Prostatic Dis

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Lycopene has a chemopreventive effect against prostate cancer but its role in prostate cancer progression is unknown; many patients increase their intake of lycopene, although there are no evidence-based guidelines to suggest an effect. Our objective was to conduct a systematic review of literature to evaluate the association between lycopene intake and prostate cancer progression. MEDLINE, EMBASE CINAHL Plus, Web of Science, AMED and CENTRAL databases were systematically searched using terms for lycopene and prostate cancer progression to identify studies published before January 2009. Eight intervention studies were identified (five with no control group; one with an unmatched control group; and two randomized controlled trials (RCTs)). An inverse association was observed between lycopene intake and PSA levels in six studies. The rates of progression measured by bone scan in one RCT were lower in the intervention group. Lycopene resulted in lowering cancer-related symptoms (pain, urinary tract symptoms), and severe toxicity or intolerance was not evident. However, the evidence available to date is insufficient to draw a firm conclusion with respect to lycopene supplementation in prostate cancer patients and larger RCTs are required in broader patient groups.

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“…No adverse effects due to lycopene consumption were observed. Similarly, no evidence of toxic effects of lycopene were seen with two synthetic crystalline lycopene (BASF lycopene 10 CWD and Lyco Vit 10%, each containing approximately 10% lycopene) 18 and lycopene derived from a fungal biomass of Blakeslea trispos, suspended in sunflower oil in rats. 19 No teratogenic effects were also observed in a two-generation rat study.…”

Section: Dietary Intake Levels Of Lycopenementioning

confidence: 97%

Lycopene: Is it Beneficial to Human Health as an Antioxidant?

Bacanlı¹,

Başaran²,

Başaran³

2017

tjps

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It is well known that free oxygen radicals play an important role in the pathogenesis of several chronic disorders. Antioxidants are known as potential scavengers of reactive oxygen species that can protect biologic membranes against oxidative damage. Recent interest in phytochemicals has increased because of their protective effects against free oxygen radicals. Lycopene, which belongs to the carotenoid family, is the most effective singlet oxygen scavenger in vitro of all the carotenoids. Foods that contain lycopene and related supplements have been reported to prevent chronic diseases including cancer, asthma, and cardiovascular disorders. The aim of the article was to give a brief review of the antioxidant properties and beneficial health effects of lycopene.

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Thirteen-week oral toxicity study of synthetic lycopene products in rats

Cited by 51 publications

References 5 publications

The effects of lycopene on methotrexate-induced liver injury in rats

The effects of lycopene on methotrexate-induced liver injury in rats

Is there a benefit from lycopene supplementation in men with prostate cancer? A systematic review

Lycopene: Is it Beneficial to Human Health as an Antioxidant?

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